LEADER 01773nam 2200361Ia 450 001 996386158903316 005 20221108032548.0 035 $a(CKB)1000000000617953 035 $a(EEBO)2240903167 035 $a(OCoLC)43078158 035 $a(EXLCZ)991000000000617953 100 $a19991222d1691 uy | 101 0 $aeng 135 $aurbn#|||a|bb| 200 12$aA survey of the microcosme, or, The anatomy of the bodies of man and woman$b[electronic resource] $ewherein the skin, veins, arteries, nerves, muscles, bones, and ligaments thereof are accurately delineated, and so disposed by pasting, as that each part of the said bodies, both inward and outward, are exactly represented. : Useful for all physicians, chyrurgeons, statuaries, painters, &c. /$fby Michael Spaher of Tyrol, and Remilinus. ; Englished by John Ireton, Chyrurgeon 210 $aLonon [sic] $cPrinted by James Moxon, and are to be sold at his shop, at the sign of the Atlas in Warwick-Lane$dM DC XCI [i.e. 1691] 215 $a[9] p. $cill 300 $aTranslation of: Catoptrum microcosmicum. 300 $aIncorrectly attributed to Stephanus Michel Spacher. Cf. Choulant, L. Hist. and bibl. of anatomic ill. 300 $aReproduction of original in: Royal College of Surgeons Library, London, England. 330 $aeebo-0137 606 $aHuman anatomy$vEarly works to 1800 615 0$aHuman anatomy 700 $aRemmelin$b Johann$f1583-1632.$01003896 701 $aMichelspacher$b Stephan$01003897 701 $aIreton$b John$cchyrurgeon.$01003898 801 0$bEAE 801 1$bEAE 801 2$bWaOLN 906 $aBOOK 912 $a996386158903316 996 $aA survey of the microcosme, or, The anatomy of the bodies of man and woman$92423927 997 $aUNISA LEADER 03665nam 2200961z- 450 001 9910557353103321 005 20220111 035 $a(CKB)5400000000042359 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77096 035 $a(oapen)doab77096 035 $a(EXLCZ)995400000000042359 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aProteases-From Basic Structure to Function to Drug Design as Targeted Therapy 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (93 p.) 311 08$a3-0365-2575-0 311 08$a3-0365-2574-2 330 $aIn the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibition strategies are one of the fastest expanding areas in the field of of drugs that show considerable promise. This Special Issue will focus on the recent advances in the discovery and development of protease inhibitors, covering the synthesis of protease inhibitors, the design of new chemical entities acting as inhibitors of special/particular types of proteases, and their mode of actions (Frolova et al. 2020; Slapak et al. 2020; Ku?nnapuu et al. 2021). In addition, the new applications of these interesting compounds/biomolecules and their limitations have been discussed and described (Wang et al. 2020; Bartos?ova?-Sojkova? et al. 2021). 606 $aResearch & information: general$2bicssc 610 $aADAMTS3 610 $aangiogenesis 610 $aapoptosis 610 $aBowman-Birk inhibitor 610 $acancer 610 $acathepsin D 610 $aCCBE1 610 $acysteine protease inhibitor 610 $adiversification 610 $aextracellular matrix 610 $aGentamicin 610 $aimmune response 610 $aKLK3 610 $alymphangiogenesis 610 $alymphedema 610 $amatrix metalloproteases 610 $amatrix metalloproteinase 610 $ametastasis 610 $aMMP 610 $aMMP14 610 $aMMP2 610 $aMMP7 610 $aMMP9 610 $anuclei 610 $apancreatic cancer 610 $aparasite 610 $aPDAC 610 $aphylogenetic analysis 610 $aplasmin 610 $aPlGF 610 $aprostate-specific antigen (PSA) 610 $aproteases 610 $aprotein structure 610 $aproteolytic activation 610 $aranacyclin 610 $asignal peptide 610 $astefin 610 $astructure-activity relationship 610 $asynergistic effect 610 $athrombin 610 $atrypsin inhibitor 610 $avascular biology 610 $avascular endothelial growth factors (VEGFs) 610 $aVEGF-A 610 $aVEGF-B 610 $aVEGF-C 610 $aVEGF-D 610 $awound healing 615 7$aResearch & information: general 700 $aKwok$b Hang Fai$4edt$01310431 702 $aShaw$b Christopher$4edt 702 $aWalker$b Brian$4edt 702 $aKwok$b Hang Fai$4oth 702 $aShaw$b Christopher$4oth 702 $aWalker$b Brian$4oth 906 $aBOOK 912 $a9910557353103321 996 $aProteases-From Basic Structure to Function to Drug Design as Targeted Therapy$94417398 997 $aUNINA