LEADER 04431nam 2201333z- 450 001 9910404084403321 005 20210212 010 $a3-03928-759-1 035 $a(CKB)4100000011302294 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61309 035 $a(oapen)doab61309 035 $a(EXLCZ)994100000011302294 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTreatment Strategies and Survival Outcomes in Breast Cancer 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (264 p.) 311 08$a3-03928-758-3 330 $aTreatment strategies for breast cancer are wide-ranging and often based on a multi-modality approach, depending on the stage and biology of the tumour and the acceptance and tolerance of the patient. They may include surgery, radiotherapy, and systemic therapy (endocrine therapy, chemotherapy, and targeted therapy). Advances in technologies such as oncoplastic surgery, radiation planning and delivery, and genomics, and the development of novel systemic therapy agents alongside their evaluation in ongoing clinical trials continue to strive for improvements in outcomes. In this Special Issue, we publish a collection of studies looking at all forms of therapeutic strategies for early and advanced breast cancer, focusing on their outcomes, notably survival. 606 $aMedicine and Nursing$2bicssc 610 $aabemaciclib 610 $aadvanced breast cancer 610 $aanthracycline resistance 610 $aantihormone therapy 610 $aAPOBEC3B 610 $aaromatase inhibitors 610 $aATM 610 $abasal-like breast cancer 610 $abiomarker 610 $aBRCA 610 $abreast cancer 610 $aBreast Cancer 610 $abreast cancer survivors 610 $abreast-conserving therapy 610 $acancer treatment 610 $acell-free DNA 610 $aCHEK2 610 $achemotherapy 610 $acirculating tumor cells 610 $acMet 610 $acolorectal cancer 610 $acomparative effectiveness 610 $acontralateral breast cancer 610 $acontralateral prophylactic mastectomy 610 $acyclin E 610 $adisease-free survival 610 $aductal carcinoma in situ 610 $aEndocrine therapy 610 $aERCC1 610 $aexercise characteristics 610 $afamily history 610 $afulvestrant 610 $agene expression 610 $ageriatric oncology 610 $aHDAC5 inhibitors 610 $aHER2 c-erbB2 610 $aHER2/neu 610 $ahistone deacetylase 610 $aincidence 610 $ainfiltrating breast cancer 610 $ainvasive breast cancer 610 $alactate dehydrogenase 610 $alapatinib 610 $aLDH 610 $aliquid biopsy 610 $aLKB1 610 $aLMK-235 610 $alymph-node ratio 610 $amammography screening 610 $amastectomy 610 $ametastatic 610 $ametastatic breast cancer 610 $aMetformin 610 $amonitoring metastatic breast cancer 610 $amutation carriers 610 $an/a 610 $aNCDB 610 $anext-generation sequencing 610 $aolder patients 610 $aOlder women 610 $aoutcome 610 $aoverdiagnosis 610 $aPALB2 610 $apalbociclib 610 $apertuzumab 610 $aphysical activity 610 $aphysical function 610 $aPIK3CA 610 $aprognosis 610 $aradiotherapy 610 $arelative survival 610 $aribociclib 610 $aSEER 610 $aserum biomarker 610 $asocial well-being 610 $aSrc kinase 610 $astage IV 610 $asurvival 610 $aT-DM1 610 $ataxane sensitivity 610 $atrastuzumab 610 $atumor biology 610 $ayoung women 610 $azero-inflated Poisson regression model 615 7$aMedicine and Nursing 700 $aCheung$b Kwok-Leung$4auth$01325396 906 $aBOOK 912 $a9910404084403321 996 $aTreatment Strategies and Survival Outcomes in Breast Cancer$93036843 997 $aUNINA LEADER 04909nam 2201033z- 450 001 9910557350303321 005 20220111 035 $a(CKB)5400000000042387 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76970 035 $a(oapen)doab76970 035 $a(EXLCZ)995400000000042387 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPlant-Based Bioactive Natural Products: Insights into Molecular Mechanisms of Action 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (170 p.) 311 08$a3-0365-2412-6 311 08$a3-0365-2413-4 330 $aMedicinal plants have been used for the maintenance of human health since ancient times, in the form of food, spices, and traditional medicines. Medicinal plant-based traditional medicines serve as the primary healthcare systems in various countries even in recent times. Alongside this, medicinal plants have also served as the one of the main sources for the discovery of new therapeutic agents. At present, various plant extracts and their isolated phytochemicals are screened and evaluated for their diverse pharmacological activities related to both communicable and non-communicable diseases. However, comparatively little focus is given to the detailed mechanism of action of these agents on the molecular level. Molecular mechanism-based studies are essential for the development of evidence-based traditional medicines as well as for the development of isolated natural products as the lead candidates for novel drug discovery. This main focus of this Special Issue "Plant-based Bioactive Natural Products: Insights into Molecular Mechanisms of Action" is to cover the recent advances in science related to the molecular mechanisms of action of natural products. A total of nine articles were published in this Special Issue, including two original research articles and two review articles. This Special Issue has provided some new experimental data on bioactive natural products and their detailed mechanisms of action for biological activities. Similarly, review articles have provided state-of-the-art information on the related topics. I would like to thank all the authors for submitting their manuscripts and the reviewers and editors for their contribution to this Special Issue. Furthermore, I am also grateful to the handling editors and staffs of Applied Sciences for their support during the preparation and finalization of this Special Issue. 517 $aPlant-Based Bioactive Natural Products 606 $aMedicine$2bicssc 610 $aamyloid beta 610 $aanti-amnesic effect 610 $aanti-apoptotic 610 $aanti-inflammation 610 $aanti-inflammatory pathways 610 $aanti-oxidant 610 $aantibiotics 610 $aantiproliferative activity 610 $aartichoke by-products 610 $aAyuFlex® 610 $aberry 610 $abeta-lactam 610 $abioactive compounds 610 $abioactivity 610 $acartilage collapse 610 $acholinergic neurotransmission 610 $acitral 610 $acognitive impairment 610 $aendothelial dysfunction 610 $aessential oil 610 $aethnobotany 610 $afluorescence and scanning electron microscopy 610 $afoodborne diseases 610 $agiardiasis 610 $aGRAS 610 $aherbal drugs 610 $aHPLC-ESI-TOF-MS 610 $ahuman breast cancer cell line 610 $ainflammation response 610 $aleaf 610 $aliensinine 610 $amacrophage 610 $amechanism of action 610 $amedicinal plants 610 $amethicillin-resistant 610 $amigration 610 $aMMPs 610 $anatural products 610 $aNigella sativa 610 $aosteoarthritis 610 $aoxidative stress 610 $aphenolic compounds 610 $aphytochemicals 610 $aPLE 610 $aproliferation 610 $aScrophularia buergeriana 610 $asrophularia buergeriana 610 $aStaphylococcus aureus 610 $asynergism 610 $atau phosphorylation 610 $aTerminalia chebula fruit 610 $atoxoplasmosis 610 $atraditional medicines 610 $aVaccinium species 610 $avascular inflammation 610 $aVepris macropylla 610 $aVSMC 615 7$aMedicine 700 $aDevkota$b Hari Prasad$4edt$01290184 702 $aDevkota$b Hari Prasad$4oth 906 $aBOOK 912 $a9910557350303321 996 $aPlant-Based Bioactive Natural Products: Insights into Molecular Mechanisms of Action$93021399 997 $aUNINA