LEADER 04759nam 2201177z- 450 001 9910557346203321 005 20220111 035 $a(CKB)5400000000042428 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76476 035 $a(oapen)doab76476 035 $a(EXLCZ)995400000000042428 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPhysiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (248 p.) 311 08$a3-0365-0562-8 311 08$a3-0365-0563-6 330 $aMembrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field. 606 $aMedicine$2bicssc 610 $aanticholinergics 610 $aantidepressant-like activity 610 $aBaricitinib 610 $abile acids 610 $achronic kidney disease 610 $achronic lung diseases 610 $achronoamperometry 610 $acisplatin nephrotoxicity 610 $adrug disposition 610 $adrug excretion 610 $adrug transport 610 $adrug transporters 610 $adrug uptake 610 $adrug-induced kidney injury 610 $adrugs 610 $aendogenous metabolism 610 $aforced swim test 610 $afunctional subgroups 610 $agene ontology 610 $agenetic polymorphisms 610 $agut microbiome 610 $ahepatotoxicity 610 $ahuman pathology atlas 610 $ainterorgan communication 610 $aisoflurane 610 $aketamine 610 $akidney 610 $akidneys 610 $alung epithelium 610 $aMalpighian tubule 610 $aMATE 610 $aMATE1 610 $an/a 610 $anephrotoxicity 610 $aNuclear receptor 610 $aOCT 610 $aOCT1 610 $aorganic anion transporter 610 $aorganic cation transporter 610 $aorganic cation transporters 610 $aorganic cations 610 $aorganic transporters 610 $apesticides 610 $aplasma membrane monoamine transporter 610 $aPPAR-alpha 610 $apulmonary drug delivery 610 $aRA 610 $aregulation 610 $aremote sensing and signaling 610 $aRemote Sensing and Signaling Theory 610 $arenal excretion 610 $aserotonin clearance 610 $aserotonin transporter 610 $aSLC22 610 $aSLC22A1 610 $aSLC22A1-5 610 $aSLC22A15 610 $aSLC22A16 610 $aSLC22A18 610 $asolute carrier 610 $asolute carrier (SLC) family 610 $asolute carrier 22 (SLC22) 610 $aspecies differences 610 $atail suspension test 610 $aTCGA 610 $aTofacitinib 610 $atransport 610 $atransporters 610 $atrospium 610 $a?2-agonists 615 7$aMedicine 700 $aCiarimboli$b Giuliano$4edt$01314808 702 $aCiarimboli$b Giuliano$4oth 906 $aBOOK 912 $a9910557346203321 996 $aPhysiology, Biochemistry, and Pharmacology of Transporters for Organic Cations$93031994 997 $aUNINA