LEADER 04759nam 2201177z- 450 001 9910557346203321 005 20220111 035 $a(CKB)5400000000042428 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76476 035 $a(oapen)doab76476 035 $a(EXLCZ)995400000000042428 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPhysiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (248 p.) 311 08$a3-0365-0562-8 311 08$a3-0365-0563-6 330 $aMembrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field. 606 $aMedicine$2bicssc 610 $aanticholinergics 610 $aantidepressant-like activity 610 $aBaricitinib 610 $abile acids 610 $achronic kidney disease 610 $achronic lung diseases 610 $achronoamperometry 610 $acisplatin nephrotoxicity 610 $adrug disposition 610 $adrug excretion 610 $adrug transport 610 $adrug transporters 610 $adrug uptake 610 $adrug-induced kidney injury 610 $adrugs 610 $aendogenous metabolism 610 $aforced swim test 610 $afunctional subgroups 610 $agene ontology 610 $agenetic polymorphisms 610 $agut microbiome 610 $ahepatotoxicity 610 $ahuman pathology atlas 610 $ainterorgan communication 610 $aisoflurane 610 $aketamine 610 $akidney 610 $akidneys 610 $alung epithelium 610 $aMalpighian tubule 610 $aMATE 610 $aMATE1 610 $an/a 610 $anephrotoxicity 610 $aNuclear receptor 610 $aOCT 610 $aOCT1 610 $aorganic anion transporter 610 $aorganic cation transporter 610 $aorganic cation transporters 610 $aorganic cations 610 $aorganic transporters 610 $apesticides 610 $aplasma membrane monoamine transporter 610 $aPPAR-alpha 610 $apulmonary drug delivery 610 $aRA 610 $aregulation 610 $aremote sensing and signaling 610 $aRemote Sensing and Signaling Theory 610 $arenal excretion 610 $aserotonin clearance 610 $aserotonin transporter 610 $aSLC22 610 $aSLC22A1 610 $aSLC22A1-5 610 $aSLC22A15 610 $aSLC22A16 610 $aSLC22A18 610 $asolute carrier 610 $asolute carrier (SLC) family 610 $asolute carrier 22 (SLC22) 610 $aspecies differences 610 $atail suspension test 610 $aTCGA 610 $aTofacitinib 610 $atransport 610 $atransporters 610 $atrospium 610 $a?2-agonists 615 7$aMedicine 700 $aCiarimboli$b Giuliano$4edt$01314808 702 $aCiarimboli$b Giuliano$4oth 906 $aBOOK 912 $a9910557346203321 996 $aPhysiology, Biochemistry, and Pharmacology of Transporters for Organic Cations$93031994 997 $aUNINA LEADER 02660nam 22006735 450 001 9910886992203321 005 20260113153211.0 010 $a9789819759484 010 $a981975948X 024 7 $a10.1007/978-981-97-5948-4 035 $a(MiAaPQ)EBC31650813 035 $a(Au-PeEL)EBL31650813 035 $a(CKB)34843081400041 035 $a(DE-He213)978-981-97-5948-4 035 $a(OCoLC)1455219348 035 $a(EXLCZ)9934843081400041 100 $a20240905d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aControl in Finite and Infinite Dimension /$fby Emmanuel Trélat 205 $a1st ed. 2024. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024. 215 $a1 online resource (145 pages) 225 1 $aSpringerBriefs on PDEs and Data Science,$x2731-7609 311 08$a9789819759477 311 08$a9819759471 320 $aIncludes bibliographical references. 327 $aChapter 1 Controllability -- Chapter 2. Optimal control -- Chapter 3 Stabilization -- Chapter 4 Semigroup theory -- Chapter 5 Linear control systems in Banach spaces. 330 $aThis book is the result of various master and summer school courses the author has taught. The objective is to provide the reader with an introduction to control theory and to the main tools allowing to treat general control systems. The author hopes this book will serve as motivation to go deeper into the theory or numerical aspects that are not covered in this book. This book might be helpful for graduate students and researchers in the field of control theory. 410 0$aSpringerBriefs on PDEs and Data Science,$x2731-7609 606 $aSystem theory 606 $aControl theory 606 $aDifferential equations 606 $aMathematical optimization 606 $aSystems Theory, Control 606 $aDifferential Equations 606 $aOptimization 606 $aTeoria de control$2thub 608 $aLlibres electrònics$2thub 615 0$aSystem theory. 615 0$aControl theory. 615 0$aDifferential equations. 615 0$aMathematical optimization. 615 14$aSystems Theory, Control. 615 24$aDifferential Equations. 615 24$aOptimization. 615 7$aTeoria de control. 676 $a629.8312 700 $aTre?lat$b Emmanuel$01791957 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910886992203321 996 $aControl in Finite and Infinite Dimension$94329779 997 $aUNINA