LEADER 04248nam 2201105z- 450 001 9910557344403321 005 20220111 035 $a(CKB)5400000000042447 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76808 035 $a(oapen)doab76808 035 $a(EXLCZ)995400000000042447 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAnimal Modeling in Cancer 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (273 p.) 311 08$a3-0365-1276-4 311 08$a3-0365-1277-2 330 $aDear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $aanimal model 610 $aanimal models 610 $aantitumor immunity 610 $abrain and nervous system cancers 610 $aCALR 610 $acancer 610 $acarcinoma 610 $aCdx 610 $achemical carcinogens 610 $acolorectal cancer 610 $aconsensus molecular subtypes 610 $adevitalization 610 $aDrosophila 610 $adrug screen 610 $aepigenetics 610 $aETO-1 610 $aFLT3 ITD 610 $agene editing 610 $agene inactivation 610 $agenetics 610 $ahematologic malignancies 610 $aIDH1/2 610 $aintestine 610 $aiPSCs 610 $aisoflavones 610 $aJAK2 610 $amammary tumor prevention 610 $amelanoma 610 $aMeLiM 610 $ametaplasia 610 $amice 610 $amicrobiota 610 $amouse model 610 $amouse models 610 $aMPL 610 $aMPN (myeloproliferative neoplasms) 610 $amutation 610 $aneural stem cells 610 $aneurogenic niches 610 $anon-mouse models 610 $aNPM-1 610 $aoncogenes 610 $apre-clinical cancer model 610 $aprogression 610 $aradiotherapy 610 $arats 610 $arodent models 610 $asignaling cascades 610 $asolid tumors 610 $asoy 610 $asparing of neurogenic regions 610 $aspontaneous regression 610 $astem cells 610 $aswine 610 $athrombosis 610 $atransgenic mice 610 $atumor suppressors 610 $atumorigenesis 610 $aubiquitin-proteasome system 610 $axenotransplantation 610 $azebrafish 610 $aZebrafish 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $aKorinek$b Vladimir$4edt$01313323 702 $aKorinek$b Vladimir$4oth 906 $aBOOK 912 $a9910557344403321 996 $aAnimal Modeling in Cancer$93031286 997 $aUNINA