LEADER 12834nam 2204465z- 450 001 9910557339303321 005 20231214133147.0 035 $a(CKB)5400000000042485 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76418 035 $a(EXLCZ)995400000000042485 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMarine Compounds and Cancer 2020 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (480 p.) 311 $a3-0365-0630-6 311 $a3-0365-0631-4 330 $aThe very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-UŽ), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development. 606 $aMedicine$2bicssc 610 $aapoptosis 610 $afucoidan 610 $ahepatocellular carcinoma 610 $areactive oxygen species 610 $a3-alkylpyridinium polymers 610 $anicotine 610 $anicotinic acetylcholine receptor 610 $anon-small cell lung carcinoma 610 $amelanoma 610 $asinulariolide 610 $aproteomic 610 $amitochondria 610 $acaspase cascade 610 $amarine fungus 610 $asediment 610 $aanthranilic acid 610 $aPenicillium paneum 610 $acytotoxicity 610 $adibromotyrosine 610 $amitochondrial dysfunction 610 $aoxidative stress 610 $atopoisomerase 610 $aepigonal organ 610 $abonnethead shark 610 $aJurkat 610 $atumor cell line 610 $ahippuristanol 610 $aPEL 610 $aAP-1 610 $aSTAT3 610 $aAkt 610 $acolorectal cancer 610 $amarine mollusc 610 $abrominated indoles 610 $ashrimp 610 $achemoprevention 610 $afatty acids 610 $acarotenoids 610 $acancer 610 $ananoparticle 610 $aosteosarcoma 610 $alung metastasis 610 $aelisidepsin 610 $alipid rafts 610 $ahydroxylated lipids 610 $afatty acid 2-hydroxylase 610 $acooperative binding 610 $amembrane permeabilization 610 $amarine organisms 610 $apolysaccharides 610 $aanticancer 610 $aanticarcinogenic 610 $amechanisms of action 610 $afumigaclavine C 610 $aanti-proliferation 610 $amitochondrial pathway 610 $aanti-cancer 610 $aanti-proliferative 610 $acarotenoid 610 $acell cycle arrest 610 $afucoxanthin 610 $aazoxymethane 610 $abioactive natural product 610 $aisatin 610 $ain vivo model 610 $aMarthasterias glacialis L. 610 $apalmitic acid 610 $aER-stress 610 $aCHOP 610 $aAntibody Drug Conjugates (ADCs) 610 $amarine antitumor agents 610 $aclinical trials 610 $aapproved antitumor agents 610 $aAD0157 610 $aangiogenesis 610 $amarine drug 610 $apyrrolidinedione 610 $asecondary metabolites 610 $acancer preventive 610 $achemopreventive 610 $atrabectedin 610 $aplitidepsin 610 $atumor-associated macrophages 610 $atumor microenvironment 610 $apreclinical 610 $aanticancer immunity 610 $aantiangiogenesis 610 $afascaplysin 610 $acyclin-dependent kinase 610 $asmall cell lung cancer 610 $acamptothecin 610 $apoly(ADP-ribose)-polymerase inhibitor 610 $abreast cancer 610 $aseaweed 610 $atherapeutic compounds 610 $aautophagy 610 $amarine drugs 610 $aautophagy inhibitors 610 $aautophagy inducers 610 $amacrolide 610 $aprogrammed cell death 610 $aenergy stress 610 $aaraguspongine C 610 $ac-Met 610 $aHER2 610 $agemcitabine 610 $apazopanib 610 $aphase I 610 $asafety 610 $asoft tissue sarcoma 610 $apachastrissamine 610 $ajaspine B 610 $acarbocyclic analogue 610 $asphingosine kinase inhibitor 610 $amolecular modeling 610 $aET-743 610 $aDNA minor groove binder 610 $asoft tissue sarcoma 610 $achemotherapy 610 $abis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) 610 $aanti-metastatic activity 610 $acell adhesion 610 $a?1-integrin 610 $aFAK 610 $aBEL-7402 cell 610 $atriterpene glycosides 610 $asea cucumbers 610 $aantitumor activities 610 $aarrest of cell cycle 610 $aantibacterial 610 $amarangucyclines 610 $adeep-sea 610 $aStreptomyces sp. SCSIO 11594 610 $aLS-1 610 $aSNU-C5/5-FU 610 $aTGF-? signaling 610 $acarcinoembryonic antigen 610 $akalkitoxin 610 $aMoorea producens 610 $amitochondria toxin 610 $aVEGF 610 $aangiogenesis inhibitor 610 $ahypoxia-inducible factor-1 610 $aHIF-1 610 $aLyngbya majuscula 610 $amarine metabolites 610 $aSZ-685C 610 $anonfunctioning pituitary adenomas 610 $aEcklonia cava 610 $aphlorotannins 610 $adieckol 610 $amigration 610 $asipholenol A 610 $aABC transporter 610 $amultidrug resistance 610 $aP-gp/ABCB1 610 $aBCRP/ABCG2 610 $aMRP1/ABCC1 610 $amarine natural products 610 $aglioblastoma 610 $axyloketal B 610 $aproliferation 610 $aTRPM7 610 $amarine compound 610 $aribosomal protein genes 610 $asnoRNA 610 $aFAU 610 $aRPS30 610 $aSNORA62 610 $aevolution 610 $aPorifera 610 $aPenicillium brevicompactum 610 $aBrevianamide 610 $aMycochromenic acid derivative 610 $aantifouling 610 $aCaribbean sponge 610 $aplakortide 610 $aendoperoxide 610 $aleukemia 610 $amulti-drug resistant leukemia 610 $aSarcophyton ehrenbergi 610 $asoft coral 610 $aterpenes 610 $acembranoids 610 $acytotoxic activity 610 $amolecular docking 610 $auveal melanoma 610 $aoxidative stress 610 $avirtual screening 610 $aTopo I inhibitor 610 $alow toxic 610 $anatural product 610 $aUlva fasciata 610 $aselenium-containing polysaccharide-protein complex 610 $apseudopterosin 610 $aNF-?B 610 $ap65 610 $ainflammation 610 $acytokine release 610 $aIL-6 610 $aTNF? 610 $aMCP-1 610 $aglucocorticoid receptor 610 $apaulomycins 610 $aMicromonospora 610 $aantitumor 610 $aCantabrian Sea-derived actinobacteria 610 $apuupehenones 610 $asponges 610 $aantiangiogenic 610 $aantitumoral 610 $aporifera/sponge 610 $acancer genes 610 $amolecular oncology 610 $abromophenol 610 $amolecular mechanisms 610 $acell cycle 610 $aPI3K/Akt 610 $ap38/ERK 610 $aROS 610 $ahuman lung cancer 610 $aglycosaminoglycans 610 $aantiproliferative 610 $aheparan sulphate 610 $agliotoxin 610 $aNSCLC 610 $aadriamycin resistance 610 $aSepia ink polysaccharides 610 $aantitumour 610 $achemosensitization 610 $aanticoagulation 610 $asea anemone 610 $adrug discovery 610 $aendothelial cells 610 $aRGD motif 610 $akunitz type inhibitor 610 $aprostate cancer 610 $aantioxidant 610 $anatural marine compounds 610 $amarine biotechnology 610 $amicroalgae 610 $amarine sponges 610 $aAeroplysinin 610 $aIsofistularin 610 $apheochromocytoma and paraganglioma 610 $ametastasis 610 $acancer progression 610 $acell adhesion molecules 610 $aintegrin ?1 610 $ahypoxia 610 $aphycocyanin 610 $anon-small cell lung cancer 610 $aNF-?B signaling 610 $amarine-derived drugs 610 $abioanalysis 610 $achromatography 610 $amanzamine A 610 $aepithelial-mesenchymal transition 610 $alung cancer 610 $acirculating tumor cells 610 $asignal transduction 610 $acisplatin 610 $aLampetra morii 610 $abuccal gland 610 $acystatin F 610 $aanti-angiogenesis 610 $acystatin superfamily 610 $aAntimicrobial peptide (AMP) 610 $aTilapia piscidin 4 (TP4) 610 $anon-small cell lung cancer (NSCLC) 610 $aitampolin A 610 $aFBDD 610 $ap38? 610 $anovel inhibitor 610 $atetracenomycin X 610 $acyclin D1 610 $aproteasomal degradation 610 $ap38 610 $ac-JUN 610 $a?-carrageenan 610 $aheparanase 610 $aanticoagulant 610 $adepolymerisation 610 $acell migration 610 $aAspergillus 610 $anaphthopyrones 610 $aendophytic fungus 610 $aLeathesia nana 610 $amangrove-derived actinomycete 610 $aansamycins 610 $adivergolides 610 $aapoptosis-inducing activity 610 $aactinomycin 610 $aEMT 610 $ainvasion 610 $alow molecular weight fucoidan extract 610 $aN-Ras 610 $aneuroblastoma-rat sarcoma 610 $aCancer 610 $aprogrammed cell death-ligand 1 610 $aprogrammed cell death-ligand 2 610 $ahuman sarcoma cell line (HT1080 cells) 610 $ahuman normal diploid fibroblast (TIG-1 cells) 610 $achimera 610 $achemical conjugation 610 $aanticancer agent 610 $ahybridization 610 $a?9-nicotinic acetylcholine receptors (nAChRs) 610 $abreast cancer cells 610 $a?O-conotoxin GeXIVA 610 $atargeted therapy 610 $agorgonian 610 $aLeptogorgia 610 $ahumulane sesquiterpenoids 610 $aanticancer activity 610 $a12-deacetyl-12-epi-scalaradial 610 $aHeLa cells 610 $aNur77 610 $aMAPK/ERK pathway 610 $aMycalin A 610 $aC15 acetogenins 610 $asynthetic analogues 610 $aantiproliferative activity 610 $aA375 and HeLa cell lines 610 $apolyoxygenated steroids 610 $asponge 610 $aHaliclona gracilis 610 $aThalassia testudinum 610 $athalassiolin B 610 $apolyphenols 610 $aCYP1A1 610 $abenzo[a]pyrene 610 $aJNK1/2 610 $anatural products 610 $asynergism 610 $aA549 cells 610 $acytoskeleton 610 $aP2X7 receptor 610 $apollution 610 $aanti-angiogenic 610 $agene expression 610 $aHSP90 610 $ainhibitor 615 7$aMedicine 700 $aHonecker$b Friedemann$4edt$01322902 702 $aDyshlovoy$b Sergey A$4edt 702 $aHonecker$b Friedemann$4oth 702 $aDyshlovoy$b Sergey A$4oth 906 $aBOOK 912 $a9910557339303321 996 $aMarine Compounds and Cancer 2020$93035241 997 $aUNINA