LEADER 12895nam 2204489z- 450 001 9910557339303321 005 20220111 035 $a(CKB)5400000000042485 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76418 035 $a(oapen)doab76418 035 $a(EXLCZ)995400000000042485 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMarine Compounds and Cancer 2020 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (480 p.) 311 08$a3-0365-0630-6 311 08$a3-0365-0631-4 330 $aThe very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-UŽ), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development. 606 $aMedicine and Nursing$2bicssc 610 $a12-deacetyl-12-epi-scalaradial 610 $a3-alkylpyridinium polymers 610 $aA375 and HeLa cell lines 610 $aA549 cells 610 $aABC transporter 610 $aactinomycin 610 $aAD0157 610 $aadriamycin resistance 610 $aAeroplysinin 610 $aAkt 610 $aangiogenesis 610 $aangiogenesis inhibitor 610 $aansamycins 610 $aanthranilic acid 610 $aanti-angiogenesis 610 $aanti-angiogenic 610 $aanti-cancer 610 $aanti-metastatic activity 610 $aanti-proliferation 610 $aanti-proliferative 610 $aantiangiogenesis 610 $aantiangiogenic 610 $aantibacterial 610 $aAntibody Drug Conjugates (ADCs) 610 $aanticancer 610 $aanticancer activity 610 $aanticancer agent 610 $aanticancer immunity 610 $aanticarcinogenic 610 $aanticoagulant 610 $aanticoagulation 610 $aantifouling 610 $aAntimicrobial peptide (AMP) 610 $aantioxidant 610 $aantiproliferative 610 $aantiproliferative activity 610 $aantitumor 610 $aantitumor activities 610 $aantitumoral 610 $aantitumour 610 $aAP-1 610 $aapoptosis 610 $aapoptosis-inducing activity 610 $aapproved antitumor agents 610 $aaraguspongine C 610 $aarrest of cell cycle 610 $aAspergillus 610 $aautophagy 610 $aautophagy inducers 610 $aautophagy inhibitors 610 $aazoxymethane 610 $aBCRP/ABCG2 610 $aBEL-7402 cell 610 $abenzo[a]pyrene 610 $abioactive natural product 610 $abioanalysis 610 $abis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) 610 $abonnethead shark 610 $abreast cancer 610 $abreast cancer cells 610 $aBrevianamide 610 $abrominated indoles 610 $abromophenol 610 $abuccal gland 610 $ac-JUN 610 $ac-Met 610 $aC15 acetogenins 610 $acamptothecin 610 $acancer 610 $aCancer 610 $acancer genes 610 $acancer preventive 610 $acancer progression 610 $aCantabrian Sea-derived actinobacteria 610 $acarbocyclic analogue 610 $acarcinoembryonic antigen 610 $aCaribbean sponge 610 $acarotenoid 610 $acarotenoids 610 $acaspase cascade 610 $acell adhesion 610 $acell adhesion molecules 610 $acell cycle 610 $acell cycle arrest 610 $acell migration 610 $acembranoids 610 $achemical conjugation 610 $achemoprevention 610 $achemopreventive 610 $achemosensitization 610 $achemotherapy 610 $achimera 610 $aCHOP 610 $achromatography 610 $acirculating tumor cells 610 $acisplatin 610 $aclinical trials 610 $acolorectal cancer 610 $acooperative binding 610 $acyclin D1 610 $acyclin-dependent kinase 610 $aCYP1A1 610 $acystatin F 610 $acystatin superfamily 610 $acytokine release 610 $acytoskeleton 610 $acytotoxic activity 610 $acytotoxicity 610 $adeep-sea 610 $adepolymerisation 610 $adibromotyrosine 610 $adieckol 610 $adivergolides 610 $aDNA minor groove binder 610 $adrug discovery 610 $aEcklonia cava 610 $aelisidepsin 610 $aEMT 610 $aendoperoxide 610 $aendophytic fungus 610 $aendothelial cells 610 $aenergy stress 610 $aepigonal organ 610 $aepithelial-mesenchymal transition 610 $aER-stress 610 $aET-743 610 $aevolution 610 $aFAK 610 $afascaplysin 610 $afatty acid 2-hydroxylase 610 $afatty acids 610 $aFAU 610 $aFBDD 610 $afucoidan 610 $afucoxanthin 610 $afumigaclavine C 610 $agemcitabine 610 $agene expression 610 $aglioblastoma 610 $agliotoxin 610 $aglucocorticoid receptor 610 $aglycosaminoglycans 610 $agorgonian 610 $aHaliclona gracilis 610 $aHeLa cells 610 $aheparan sulphate 610 $aheparanase 610 $ahepatocellular carcinoma 610 $aHER2 610 $aHIF-1 610 $ahippuristanol 610 $aHSP90 610 $ahuman lung cancer 610 $ahuman normal diploid fibroblast (TIG-1 cells) 610 $ahuman sarcoma cell line (HT1080 cells) 610 $ahumulane sesquiterpenoids 610 $ahybridization 610 $ahydroxylated lipids 610 $ahypoxia 610 $ahypoxia-inducible factor-1 610 $aIL-6 610 $ain vivo model 610 $ainflammation 610 $ainhibitor 610 $aintegrin ?1 610 $ainvasion 610 $aisatin 610 $aIsofistularin 610 $aitampolin A 610 $ajaspine B 610 $aJNK1/2 610 $aJurkat 610 $akalkitoxin 610 $akunitz type inhibitor 610 $aLampetra morii 610 $aLeathesia nana 610 $aLeptogorgia 610 $aleukemia 610 $alipid rafts 610 $alow molecular weight fucoidan extract 610 $alow toxic 610 $aLS-1 610 $alung cancer 610 $alung metastasis 610 $aLyngbya majuscula 610 $amacrolide 610 $amangrove-derived actinomycete 610 $amanzamine A 610 $aMAPK/ERK pathway 610 $amarangucyclines 610 $amarine antitumor agents 610 $amarine biotechnology 610 $amarine compound 610 $amarine drug 610 $amarine drugs 610 $amarine fungus 610 $amarine metabolites 610 $amarine mollusc 610 $amarine natural products 610 $amarine organisms 610 $amarine sponges 610 $amarine-derived drugs 610 $aMarthasterias glacialis L. 610 $aMCP-1 610 $amechanisms of action 610 $amelanoma 610 $amembrane permeabilization 610 $ametastasis 610 $amicroalgae 610 $aMicromonospora 610 $amigration 610 $amitochondria 610 $amitochondria toxin 610 $amitochondrial pathway 610 $amitochondrial dysfunction 610 $amolecular docking 610 $amolecular mechanisms 610 $amolecular modeling 610 $amolecular oncology 610 $aMoorea producens 610 $aMRP1/ABCC1 610 $amulti-drug resistant leukemia 610 $amultidrug resistance 610 $aMycalin A 610 $aMycochromenic acid derivative 610 $aN-Ras 610 $an/a 610 $ananoparticle 610 $anaphthopyrones 610 $anatural marine compounds 610 $anatural product 610 $anatural products 610 $aneuroblastoma-rat sarcoma 610 $aNF-?B 610 $aNF-?B signaling 610 $anicotine 610 $anicotinic acetylcholine receptor 610 $anon-small cell lung cancer 610 $anon-small cell lung cancer (NSCLC) 610 $anon-small cell lung carcinoma 610 $anonfunctioning pituitary adenomas 610 $anovel inhibitor 610 $aNSCLC 610 $aNur77 610 $aosteosarcoma 610 $aoxidative stress 610 $aoxidative stress 610 $aP-gp/ABCB1 610 $aP2X7 receptor 610 $ap38 610 $ap38/ERK 610 $ap38? 610 $ap65 610 $apachastrissamine 610 $apalmitic acid 610 $apaulomycins 610 $apazopanib 610 $aPEL 610 $aPenicillium brevicompactum 610 $aPenicillium paneum 610 $aphase I 610 $apheochromocytoma and paraganglioma 610 $aphlorotannins 610 $aphycocyanin 610 $aPI3K/Akt 610 $aplakortide 610 $aplitidepsin 610 $apollution 610 $apoly(ADP-ribose)-polymerase inhibitor 610 $apolyoxygenated steroids 610 $apolyphenols 610 $apolysaccharides 610 $aPorifera 610 $aporifera/sponge 610 $apreclinical 610 $aprogrammed cell death 610 $aprogrammed cell death-ligand 1 610 $aprogrammed cell death-ligand 2 610 $aproliferation 610 $aprostate cancer 610 $aproteasomal degradation 610 $aproteomic 610 $apseudopterosin 610 $apuupehenones 610 $apyrrolidinedione 610 $areactive oxygen species 610 $aRGD motif 610 $aribosomal protein genes 610 $aROS 610 $aRPS30 610 $asafety 610 $aSarcophyton ehrenbergi 610 $asea anemone 610 $asea cucumbers 610 $aseaweed 610 $asecondary metabolites 610 $asediment 610 $aselenium-containing polysaccharide-protein complex 610 $aSepia ink polysaccharides 610 $ashrimp 610 $asignal transduction 610 $asinulariolide 610 $asipholenol A 610 $asmall cell lung cancer 610 $aSNORA62 610 $asnoRNA 610 $aSNU-C5/5-FU 610 $asoft coral 610 $asoft tissue sarcoma 610 $asoft tissue sarcoma 610 $asphingosine kinase inhibitor 610 $asponge 610 $asponges 610 $aSTAT3 610 $aStreptomyces sp. SCSIO 11594 610 $asynergism 610 $asynthetic analogues 610 $aSZ-685C 610 $atargeted therapy 610 $aterpenes 610 $atetracenomycin X 610 $aTGF-? signaling 610 $aThalassia testudinum 610 $athalassiolin B 610 $atherapeutic compounds 610 $aTilapia piscidin 4 (TP4) 610 $aTNF? 610 $aTopo I inhibitor 610 $atopoisomerase 610 $atrabectedin 610 $atriterpene glycosides 610 $aTRPM7 610 $atumor cell line 610 $atumor microenvironment 610 $atumor-associated macrophages 610 $aUlva fasciata 610 $auveal melanoma 610 $aVEGF 610 $avirtual screening 610 $axyloketal B 610 $a?9-nicotinic acetylcholine receptors (nAChRs) 610 $a?O-conotoxin GeXIVA 610 $a?1-integrin 610 $a?-carrageenan 615 7$aMedicine and Nursing 700 $aHonecker$b Friedemann$4edt$01322902 702 $aDyshlovoy$b Sergey A$4edt 702 $aHonecker$b Friedemann$4oth 702 $aDyshlovoy$b Sergey A$4oth 906 $aBOOK 912 $a9910557339303321 996 $aMarine Compounds and Cancer 2020$93035241 997 $aUNINA LEADER 03383nam 2200457z- 450 001 9910261133203321 005 20210211 035 $a(CKB)4100000002484754 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46252 035 $a(oapen)doab46252 035 $a(EXLCZ)994100000002484754 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEmerging Functions of Septins 210 $cFrontiers Media SA$d2017 215 $a1 online resource (126 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-287-5 330 $aTogether with the microfilament, microtubule and intermediate-filament networks, septins constitute an integral part of the eukaryotic cytoskeleton. Historically identified as proteins critical for septum formation in the budding yeast Saccharomyces cerevisiae, septin family GTPases are expressed and participate in the process of cytokinesis in most eukaryotes except higher plants. More than a dozen septin genes in mammals, together with various splice variants displaying tissue-specific expression patterns and flexible hetero-polymeric higher-order assembly achieve an unfathomable complexity superior to the other cytoskeletal components. Even though the initial studies in the septin field was restricted to their evolutionarily conserved role in cell division, strong expression of septins in the non-dividing cells of the brain generated great interest in understanding their role in neuronal morphogenesis and other aspects of cellular function. On one hand, recent developments indicate complex non-canonical roles for septins in diverse processes ranging from neuronal development to immune response and calcium signaling. On the other hand several lines of data including those from knockout models question the universal role for septins in animal cell cytokinesis. Mammalian hematopoietic cells seem to proliferate and efficiently undergo cytokinesis in the absence of pivotal septin proteins in a context-dependent manner. The lack of septin-dependence of hematopoiesis also opens the possibility of safely targeting septin-dependent cytokinesis for solid-tumor therapy. Thus the septin field is perfectly poised with novel roles for septins being discovered and the basic understanding on septin assembly and its canonical functions constantly revisited. The objective of this research topic was to provide an exclusive platform for discussing these rapid advances in the septin field. With a mixture of reviews and research articles encompassing diverse areas of septin research, ranging from the humble yeast model to human cancer, this ebook will be an interesting reading material for both experts as well as new comers to the septin field. 606 $aBiology, life sciences$2bicssc 610 $abudding 610 $acancer 610 $aCilia 610 $acytokinesis 610 $acytoskeleton 610 $aGTPase 610 $amutation 610 $aseptin 610 $aSOCE 610 $ayeast 615 7$aBiology, life sciences 700 $aManoj B. Menon$4auth$01331580 702 $aMatthias Gaestel$4auth 906 $aBOOK 912 $a9910261133203321 996 $aEmerging Functions of Septins$93040453 997 $aUNINA