LEADER 06897nam 2202221z- 450 001 9910557336603321 005 20220111 035 $a(CKB)5400000000042512 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77126 035 $a(oapen)doab77126 035 $a(EXLCZ)995400000000042512 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Retina in Health and Disease 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (465 p.) 311 08$a3-0365-2653-6 311 08$a3-0365-2652-8 330 $aVision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy. 606 $aMedicine and Nursing$2bicssc 606 $aNeurosciences$2bicssc 610 $a3,5-DHBA 610 $aAc2-26 610 $aAfrican-American 610 $aage-related macular degeneration 610 $aAII amacrine cell 610 $aaltricial bird species 610 $aAlzheimer's disease 610 $aAMD 610 $aamyloid 610 $aangiogenesis 610 $aangiography 610 $aantioxidants 610 $aapoptosis 610 $aarterioles 610 $aastrocytes 610 $aATP 610 $aatypical cannabinoid receptors 610 $aautophagy 610 $aaxon 610 $abetulinic acid 610 $abioenergetics 610 $abiomarker 610 $ablack 610 $acatalase 610 $aCD4+CD25+ 610 $acellular senescence 610 $aCharles Bonnet syndrome 610 $aclinical trials 610 $acognitive decline 610 $acomplement cascade 610 $acomplication 610 $adevelopment 610 $adiabetes 610 $adiabetes mellitus 610 $adiabetic retinopathy 610 $adLGN 610 $aDrp1 610 $aearly detection 610 $aeccentricity 610 $aEEG 610 $aelectron microscopy 610 $aelectroretinography 610 $aendoplasmic reticulum 610 $aepidermal growth factor 610 $aexendin-4 610 $aexperimental models 610 $aeye 610 $aeye inflammation 610 $afingolimod 610 $aFPR receptor 610 $afunctional analysis 610 $agap junction 610 $agerm-free mice 610 $aGFAP 610 $aglucagon-like peptide-1 610 $aGPR81 610 $agrowth cone 610 $aGRP78 610 $agut microbiome 610 $agut-retina axis 610 $aHCAR1 610 $aHDAC 610 $ahigh-fat diet 610 $ahistone deacetylase 610 $ahyperglycemia 610 $ahypoxia 610 $aimmunodeficient RCS rat 610 $aimmunohistochemistry 610 $ainflammation 610 $ainflammatory mediators 610 $aiPSC 610 $aiPSC-RPE 610 $aischemia-reperfusion injury 610 $akallikrein-kinin system 610 $akinin receptors 610 $alactate 610 $aLED screen 610 $alight damage 610 $alipopolysaccharide 610 $amacroglia 610 $amesenchymal stem cells 610 $ametabolism 610 $amicroglia 610 $amicroglia morphotype 610 $amicrovascular 610 $amicrovascular complications and dysfunction 610 $amitochondria 610 $amonkeys 610 $amotor protein 610 $aMu?ller cells 610 $amultiple sclerosis 610 $amyosin 1C 610 $an/a 610 $anatural bioactive extracts 610 $aneurod 610 $aneurodegeneration 610 $aneuroprotection 610 $aneurovascular unit 610 $aNotch 610 $aON/OFF asymmetry 610 $aoptic nerve crush 610 $aoptic neuritis 610 $aoptical coherence tomography 610 $aoptical filter 610 $aosteopontin 610 $aouter segments 610 $aoxidative stress 610 $aparvalbumin 610 $aphotoreceptor 610 $aphotoreceptors 610 $aprecocial bird species 610 $aprogenitor cell 610 $aprogrammed cell death 610 $aProx1 610 $areactive oxygen species 610 $aregeneration 610 $aremodeling 610 $arespiration 610 $aresting state 610 $aretina 610 $aretinal degeneration 610 $aretinal degenerative diseases 610 $aretinal detachment 610 $aretinal fluorescence imaging 610 $aretinal ganglion cells 610 $aretinal glial cell 610 $aretinal inflammation 610 $aretinal light injury 610 $aretinal microglia 610 $aretinal pigment epithelium 610 $aretinal protection 610 $aretinal transplantation 610 $aretinal vessels 610 $aretinogenesis 610 $aretinopathy 610 $arhodopsin 610 $aRNA sequencing 610 $asenescence-associated galactosidase activity 610 $asignal transducer and activator of transcription 3 610 $aspinal cord injury 610 $astem cell therapy 610 $astress response 610 $asystemic disease 610 $atrichostatin A (TSA) 610 $atypical cannabinoid receptors 610 $aultrathin parylene 610 $aunfolded protein response 610 $avascular endothelial growth factor (VEGF) 610 $avascularization 610 $avisual function 610 $avisual hallucination 610 $avisual system 610 $azebrafish 615 7$aMedicine and Nursing 615 7$aNeurosciences 700 $aPtito$b Maurice$4edt$01290173 702 $aBouskila$b Joseph$4edt 702 $aPtito$b Maurice$4oth 702 $aBouskila$b Joseph$4oth 906 $aBOOK 912 $a9910557336603321 996 $aThe Retina in Health and Disease$93021386 997 $aUNINA LEADER 05380nam 2201393z- 450 001 9910557599103321 005 20210501 035 $a(CKB)5400000000043686 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69435 035 $a(oapen)doab69435 035 $a(EXLCZ)995400000000043686 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aApplication of the Systems Approach to the Management of Complex Water Systems 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (314 p.) 311 08$a3-03943-769-0 311 08$a3-03943-770-4 330 $aDuring the past five decades, we have witnessed a tremendous evolution in water resource system management. Three characteristics of this evolution are of particular note: First, the application of the systems approach to complex water management problems has been established as one of the most important advances in the field of water resource management. Second, the past five decades have brought a remarkable transformation of attitude in the water resource management community towards environmental concerns and action to address these concerns. Third, applying the principles of sustainability to water resource decision-making requires major changes in the objectives on which decisions are based, and an understanding of the complicated inter-relationships between existing ecological, economic, and social factors. The Special Issue includes 15 contributions that offer insights into contemporary problems, approaches, and issues related to the management of complex water resources systems. It will be presumptuous to say that these 15 contributions characterize the success or failure of the systems approach to support water resources decision-making. However, these contributions offer interesting lessons from current experiences and highlight possible future work. 606 $aHistory of engineering and technology$2bicssc 610 $aadaptive capacity 610 $aagent-based modeling 610 $aaggregation-decomposition 610 $aANP 610 $aartificial intelligence 610 $aartificial recharge 610 $aaveraging procedures 610 $aCanada 610 $aCHANS 610 $aclimate change 610 $acommunity 610 $acomplex water system 610 $acomplexity 610 $acoupled human-natural systems 610 $adecision-making 610 $adifferential equations 610 $adisaster 610 $afreshwater resources 610 $afuzzy optimization 610 $agroundwater 610 $agroup consensus 610 $agroup decision-support system 610 $aHEC-HMS 610 $ahuman-nature systems 610 $ahuman-water systems 610 $ahydro-sociology 610 $ahydrology 610 $aimpact 610 $aimplementation 610 $ainnovation 610 $aintegrated urban watershed management 610 $aintegrated water resources management 610 $aItaly 610 $aIWRM 610 $aKashafroud watershed 610 $aLim river 610 $aLim water systems 610 $amachine learning 610 $amanagement 610 $amodeling perspectives 610 $amodelling 610 $amulti-agent reinforcement learning 610 $amulti-purpose dam 610 $amultiobjective optimisation 610 $amultireservoir operations 610 $an/a 610 $aneural networks 610 $aoptimization 610 $aperception 610 $aperformance-based engineering 610 $aplanning 610 $apolitical processes 610 $aregional climate models 610 $areservoir operation 610 $areservoir-river system 610 $aresilience 610 $arisk 610 $arisk analysis 610 $ariver abstraction 610 $aSES 610 $asimulation 610 $asocial-ecological systems 610 $asocio-hydrologic modeling 610 $asocio-hydrology 610 $asociohydrology 610 $aSoft Systems 610 $astakeholder 610 $astochastic dynamic programming 610 $aSuDS 610 $asystem analysis 610 $asystem dynamics 610 $asystems 610 $asystems analyses 610 $asystems assessment 610 $atreated wastewater 610 $auncertainty 610 $auncertainty assessment 610 $awater footprint 610 $awater management 610 $awater policy 610 $awater portfolio planning 610 $awater quantity-quality management 610 $awater resource modelling 610 $awater resources 610 $awater resources management 610 $awater resources systems 610 $awine production 610 $awinemaking sector 615 7$aHistory of engineering and technology 700 $aSimonovic?$b Slobodan P$4edt$00 702 $aSimonovic?$b Slobodan P$4oth 906 $aBOOK 912 $a9910557599103321 996 $aApplication of the Systems Approach to the Management of Complex Water Systems$93032069 997 $aUNINA