LEADER 03850nam 2200865z- 450 001 9910557303803321 005 20231214133158.0 035 $a(CKB)5400000000042818 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69297 035 $a(EXLCZ)995400000000042818 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPeriodontitis$eFrom Dysbiotic Microbial Immune Response to Systemic Inflammation 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (122 p.) 311 $a3-03943-507-8 311 $a3-03943-508-6 330 $aPeriodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate and release virulence factors, they cause an imbalance in the host inflammatory response that induces degenerative processes in the surrounding tissues. This process is often slow, and the disease affects mainly older people, but the process could be rapid and affect young individuals if certain pathogens colonize the area. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, express virulence factors, including proteases and exotoxins. Periodontal bacteria and their products can be translocated to the peripheral circulation and are therefore linked to the risk pattern of several systemic diseases. However, it is not known if the increased risk for systemic disease associated with periodontitis is an effect of the invading bacteria and/or their released products, the release of components from the local inflammatory response, or a common host susceptibility pattern. The most studied periodontitis-associated systemic diseases are cardiovascular diseases and rheumatoid arthritis. Here, we want to shed light on mechanisms behind the associations of periodontal infections with systemic inflammation. 517 $aPeriodontitis 606 $aMedicine$2bicssc 610 $aapical periodontitis 610 $aadaptive immunity 610 $asaliva 610 $aserum 610 $aantibody 610 $aAggregatibacter actinomycetemcomitans 610 $ainvasiveness 610 $aleukotoxin 610 $acytolethal distending toxin 610 $aserum resistance 610 $aouter membrane vesicles 610 $aoral microbiome 610 $anitric oxide 610 $anitrate 610 $anitrite 610 $aperiodontal disease 610 $aalveolar bone loss 610 $agingiva 610 $abacteria 610 $abiofilm 610 $aimmunity 610 $ainflammation 610 $asmoking 610 $aRheumatoid arthritis 610 $aPorphyromonas gingivalis 610 $aperiodontitis 610 $acitrullination 610 $apeptidylarginine deiminase 610 $aACPA 610 $aanti-CCP 610 $ahost response 610 $ainfection 610 $aoral microbiota 610 $avirulence factors 610 $ametabolites 610 $aTREM-1 610 $aintervention 610 $aLP17 610 $aIL-17 610 $aRANKL 610 $aOPG 610 $acardiovascular diseases 610 $arheumatoid arthritis 610 $ainflammatory response 615 7$aMedicine 700 $aJohansson$b Anders$4edt$01161470 702 $aJohansson$b Anders$4oth 906 $aBOOK 912 $a9910557303803321 996 $aPeriodontitis$93018837 997 $aUNINA