LEADER 01011nam0-22003491i-450- 001 990007837640403321 005 20060206121349.0 010 $a88-420-6333-9 035 $a000783764 035 $aFED01000783764 035 $a(Aleph)000783764FED01 035 $a000783764 100 $a20031113d2001----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aBaroni in laguna$a<>società del malessere$fGiuseppe Fiori 210 $aRoma$cLaterza$d2001 215 $aXVI, 212 p.$d20 cm 225 1 $aEconomica Laterza$v216 610 0 $aBrigantaggio$aSardegna$aCondizioni economiche e sociali 676 $a330.9459 676 $a305.96392$v21$zita 700 1$aFiori,$bGiuseppe$f<1923-2003>$0127845 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990007837640403321 952 $a330.945 FIO 1$bBibl.48581$fFLFBC 959 $aFLFBC 996 $aSocietà del malessere$9478468 996 $aBaroni in laguna$9672180 997 $aUNINA LEADER 03948nam 2200865z- 450 001 9910557297603321 005 20210501 035 $a(CKB)5400000000041063 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69163 035 $a(oapen)doab69163 035 $a(EXLCZ)995400000000041063 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBotulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (196 p.) 311 08$a3-03936-670-X 311 08$a3-03936-671-8 330 $aThe botulinum toxin has been widely applied in the treatment of functional urological diseases, such as overactive bladder, neurogenic detrusor overactivity, interstitial cystitis, and chronic pelvic pain syndrome. Evidence has shown that the botulinum toxin not only affects the release of neuropeptides from motor nerve endings, but also connects sensory nerves to the central nervous system. Inflammation in the central nervous system can be reduced after botulinum toxin treatment. The scope of therapeutic targets involves detrusor overactivity, sensory disorders, bladder pain and pelvic pain, and inflammatory disorders of the bladder, prostate, and bladder outlet. Although the actual pathophysiological mechanism of the action of the botulinum toxin has not been completely demonstrated, an anti-inflammation effect might be the predominant therapeutic mechanism for functional urological disorders such as an overactive bladder, bladder hypersensitivity, interstitial cystitis, chronic pelvic pain syndrome, chronic prostatitis, and lower urinary tract symptoms/benign prostatic hyperplasia. This Special Issue of Toxins covers the therapeutic potentials of the botulinum toxin on lower urinary tract dysfunctions, with emphasis on the mechanism of pharmacological action and clinical effects. 606 $aMedicine and Nursing$2bicssc 610 $aantimuscarinics 610 $abenign prostatic hyperplasia 610 $abladder 610 $abladder pain 610 $abotulinum toxin 610 $aBotulinum toxin 610 $abotulinum toxin A 610 $achronic pelvic pain syndrome 610 $achronic prostatitis 610 $adiabetes mellitus 610 $adrug delivery 610 $afunctional urological disorders 610 $afunctional urology disorder 610 $ahuman 610 $ahydrodistention 610 $ainflammation 610 $ainterstitial cystitis 610 $alower urinary tract symptoms 610 $amaximal bladder capacity 610 $amid-urethral sling 610 $amolecular mechanism 610 $anetwork meta-analysis 610 $aneurogenic detrusor overactivity 610 $aonabotulinumtoxinA 610 $aOnabotulinumtoxinA 610 $aoveractive bladder 610 $apain 610 $apainful bladder syndrome 610 $apathophysiology 610 $apelvic pain 610 $aperipheral tibial nerve stimulation 610 $apredictor 610 $aprostatitis 610 $asacral neuromodulation 610 $asensation 610 $atherapeutic outcome 610 $atherapy 610 $atreatment 610 $aurethra 610 $aurethral sphincter 610 $aurethral sphincter dysfunction 610 $aurinary incontinence 610 $aurodynamics 610 $avoiding 615 7$aMedicine and Nursing 700 $aKuo$b Hann-Chorng$4edt$01281276 702 $aKuo$b Hann-Chorng$4oth 906 $aBOOK 912 $a9910557297603321 996 $aBotulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders$93018456 997 $aUNINA