LEADER 03805nam 2200913z- 450 001 9910557287703321 005 20210501 035 $a(CKB)5400000000041163 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68933 035 $a(oapen)doab68933 035 $a(EXLCZ)995400000000041163 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPharmacogenomics and Personalized Medicine 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (208 p.) 311 08$a3-03936-730-7 311 08$a3-03936-731-5 330 $aPharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient's genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics. 606 $aMedicine$2bicssc 610 $aacenocoumarol 610 $aalleles 610 $aAML 610 $aazathioprine 610 $abreast cancer subtype 610 $aCDSS 610 $achildhood acute lymphoblastic leukemia 610 $acisplatin 610 $aclopidogrel 610 $acrosstalk network 610 $aCYP2C9 610 $adrug resistance 610 $afocal copy number alterations 610 $agene expression 610 $agenetic polymorphisms 610 $agenotype 610 $aglutathione-S transferase 610 $ahigh-throughput analysis 610 $ahuman genetics 610 $aimplementation 610 $ainflammatory bowel disease 610 $aINR 610 $akidney injury 610 $amicroRNAs 610 $amiRNA 610 $anephrotoxicity 610 $anucleoside analogs 610 $aovarian cancer 610 $apanel 610 $apathway 610 $apersonalized medicine 610 $apharmacogenetics 610 $apharmacogenetics study 610 $apharmacogenomics 610 $apharmacokinetics 610 $apharmacology 610 $apharmacotranscriptomics 610 $aphenotype 610 $aplatinum resistance 610 $apre-emptive 610 $aprecision drugs 610 $aprecision medicine 610 $aVKORC1 610 $awarfarin 610 $awarfarin initiation phase of therapy 610 $awhole exome sequencing 615 7$aMedicine 700 $aCecchin$b Erika$4edt$01281270 702 $aStocco$b Gabriele$4edt 702 $aCecchin$b Erika$4oth 702 $aStocco$b Gabriele$4oth 906 $aBOOK 912 $a9910557287703321 996 $aPharmacogenomics and Personalized Medicine$93018447 997 $aUNINA LEADER 03180nam 2200601 a 450 001 9910958625703321 005 20251117095451.0 010 $a9786613582027 010 $a9781280486791 010 $a1280486791 010 $a9780299148737 010 $a0299148734 035 $a(CKB)2550000000101901 035 $a(OCoLC)45733847 035 $a(CaPaEBR)ebrary10556526 035 $a(SSID)ssj0000172058 035 $a(PQKBManifestationID)11177348 035 $a(PQKBTitleCode)TC0000172058 035 $a(PQKBWorkID)10152333 035 $a(PQKB)11113339 035 $a(SSID)ssj0000656413 035 $a(PQKBManifestationID)12249254 035 $a(PQKBTitleCode)TC0000656413 035 $a(PQKBWorkID)10633870 035 $a(PQKB)11464595 035 $a(MiAaPQ)EBC3445236 035 $a(Perlego)4385936 035 $a(EXLCZ)992550000000101901 100 $a20150424h19951995 uy 0 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 12$aA history of fascism, 1914-1945 /$fStanley G. Payne 210 1$aMadison :$cUniversity of Wisconsin Press,$d1995 210 4$aŠ1995 215 $a1 online resource (xiv, 613 pages) $cillustrations 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a9780299148744 311 0 $a0299148742 327 $aThe cultural transformation of the fin de sie?cle Radical and authoritarian nationalism in late nineteenth-century Europe The impact of World War I The rise of Italian fascism, 1919-1929 The growth of nonfascist authoritarianism in Southern and Eastern Europe, 1919-1929 German National Socialism The transformation of Italian fascism, 1929-1939 Four major variants of fascism The minor movements Fascism outside Europe? World War II : climax and destruction of fascism Interpretations of fascism Generic fascism? Fascism and modernization Elements of a retrodictive theory of fascism Epilogue: Neofascism : a fascism in our future? 330 8 $a" A History of Fascism is an invaluable sourcebook, offering a rare combination of detailed information and thoughtful analysis. It is a masterpiece of comparative history, for the comparisons enhance our understanding of each part of the whole. The term 'fascist, ' used so freely these days as a pejorative epithet that has nearly lost its meaning, is precisely defined, carefully applied and skillfully explained. The analysis effectively restores the dimension of evil."-Susan Zuccotti, The Nation "A magisterial, wholly accessible, engaging study.... Payne defines fascism as a form of ultranationalism espousing a myth of national rebirth and marked by extreme elitism, mobilization of the masses, exaltation of hierarchy and subordination, oppression of women and an embrace of violence and war as virtues."- Publishers Weekly 606 $aFascism$xHistory 606 $aFascism 615 0$aFascism$xHistory. 615 0$aFascism. 676 $a320.5/33/09 700 $aPayne$b Stanley G.$0140002 801 0$bPQKB 906 $aBOOK 912 $a9910958625703321 996 $aHistory of fascism, 1914-1945$91254468 997 $aUNINA