LEADER 03157nam 2200457z- 450 001 9910557257503321 005 20211118 035 $a(CKB)5400000000041382 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73635 035 $a(oapen)doab73635 035 $a(EXLCZ)995400000000041382 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDevelopment of Humanized Mouse Models for Infectious Diseases and Cancer 210 $cFrontiers Media SA$d2020 215 $a1 online resource (169 p.) 311 08$a2-88963-481-7 330 $aWhile the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre-clinical data more akin to that seen in the natural human host. There have been many recent advances in the field that encompass derivation of new transgenic breeds of immunodeficient mice harboring human cytokines and HLA alleles that permit improved human cell engraftment and differentiation. The ability to generate humanized mice with a functional immune system together with human tissue transplantation such as a functional liver has now paved the way for new experimentation not previously feasible and is beginning to shed light on the complex picture of human pathophysiology and immunopathogenesis. Specifically, human specific pathogens such as HIV, hepatitis viruses and malaria parasites are being studied in these systems and important data on pathogen life cycles in human cells in vivo, viral latency and human specific immune responses are being gathered. In the hematology front, new data are emerging on graft versus host disease using these models. Patient derived xenograft models endowed with transplanted human immune cells are permitting evaluations of various immunotherapies and identification of specific drugs for cancer therapy. Pathogenesis and immune responses for deadly pathogens, such as Ebola and newly emerged viruses like Zika are also being studied, adding a new twist and generating new knowledge in the context of human target cells in an in vivo setting. 606 $aImmunology$2bicssc 606 $aMedicine and Nursing$2bicssc 610 $ahumanized mice for HIV 610 $ahumanized mice in cancer research 610 $ahumanized mice in infectious disease research 610 $aimproved humanized mouse models 610 $amalaria 610 $anew humanized mouse models 610 $avaccines and therapeutics 615 7$aImmunology 615 7$aMedicine and Nursing 700 $aTsuji$b Moriya$4edt$01325116 702 $aAkkina$b Ramesh$4edt 702 $aTsuji$b Moriya$4oth 702 $aAkkina$b Ramesh$4oth 906 $aBOOK 912 $a9910557257503321 996 $aDevelopment of Humanized Mouse Models for Infectious Diseases and Cancer$93036597 997 $aUNINA