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035   $a(CKB)5400000000041398
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73737
035   $a(oapen)doab73737
035   $a(EXLCZ)995400000000041398
100   $a20202111d2020      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aObesity and Diabetes: Implications for Brain-Immunometabolism
210   $cFrontiers Media SA$d2020
215   $a1 online resource (204 p.)
311 08$a2-88963-585-6 
330   $aObesity is a major worldwide health problem, reached epidemic proportions that affects both developed and developing countries. Obesity increases the risk for a wide metabolic conditions including type 2 diabetes. Additionally, a relationship between obesity, diabetes and cognitive function, as well as risk of dementias have come to attention. The link between these pathologies is the activation of the inflammatory process. Obesity is considered as a chronic low grade inflammatory disease that affects numerous tissues including the brain. The consumption of large amounts of dietary fats, particularly saturated fatty acids can impair hypothalamic neuronal metabolism and circuitries that control whole-body energy homeostasis, consequently leading to obesity. Homeostatic control of brain metabolism is essential for neuronal activity. Neuroendocrine signals play a major role in the regulation of brain metabolism and also peripheral energy balance. Brain inflammation is a major cause for brain metabolic dysfunction and it is known to impair the control of whole-body energy homeostasis and also brain activity in several metabolic and neurodegenerative disorders. Metabolic diseases, inflammation, and brain diseases are likely linked, however a clear mechanistic understanding has remained elusive. This Research Topic collects articles on the neurometabolic changes in the brain induced by inflammatory processes associated with obesity and chronic metabolic disorders.
517   $aObesity and Diabetes
606   $aNeurosciences$2bicssc
606   $aScience: general issues$2bicssc
610   $adiabetes
610   $aenergy homeostasis
610   $ainflammation
610   $aneurodegeneration
610   $aobesity
615  7$aNeurosciences
615  7$aScience: general issues
700   $aGaspar$b Joana M$4edt$01306142
702   $aLatini$b Alexandra$4edt
702   $aTalbot$b Sebastien$4edt
702   $aGaspar$b Joana M$4oth
702   $aLatini$b Alexandra$4oth
702   $aTalbot$b Sebastien$4oth
906   $aBOOK
912   $a9910557255903321
996   $aObesity and Diabetes: Implications for Brain-Immunometabolism$93028314
997   $aUNINA