LEADER 02926nam 2200505z- 450 001 9910557221703321 005 20211118 035 $a(CKB)5400000000041727 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73708 035 $a(oapen)doab73708 035 $a(EXLCZ)995400000000041727 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPurinergic Signaling in Health and Disease 210 $cFrontiers Media SA$d2020 215 $a1 online resource (330 p.) 311 08$a2-88963-556-2 330 $aAdenosine 5'-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy "currency." After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communication in living organisms. Additionally, the contribution of pyrimidine nucleotides (such as UTP and UDP) and sugar-nucleotides (i.e., UDP-glucose and UDP-galactose) have been more recently discovered. Purinergic signaling plays major physiological roles in mammalian central nervous system (CNS) such as neurotransmission, neuromodulation, communication in glial network and between neurons and glia. Extracellular ATP and its metabolic breakdown is a source of other nucleotides and adenosine providing the versatile basis for complex purinergic signaling through the activation of several families of purinergic receptors. G-protein coupled P1 receptors for adenosine, ionotropic P2X receptors for ATP and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in central neurons at pre-and post-synapse and in glial cells. Alterations of purinergic signals are associated with major CNS disorders including chronic pain, brain trauma ischemia, epilepsy, neurodegenerative diseases such as Alzheimer disease or Amyotrophic lateral sclerosis associated with neuro-inflammation as well as neuropsychiatric diseases, including depression, anxiety and schizophrenia. 606 $aNeurosciences$2bicssc 606 $aScience: general issues$2bicssc 610 $aA(2A) 610 $aA(2B)) receptors 610 $aadenosine (A(1) 610 $aCNS 610 $aCNS-disorder 610 $aP2X 610 $aP2Y 610 $apurine 610 $apurinergic signaling 615 7$aNeurosciences 615 7$aScience: general issues 700 $aBoué-Grabot$b Eric$4edt$01326713 702 $aBlum$b David$4edt 702 $aCeruti$b Stefania$4edt 702 $aBoué-Grabot$b Eric$4oth 702 $aBlum$b David$4oth 702 $aCeruti$b Stefania$4oth 906 $aBOOK 912 $a9910557221703321 996 $aPurinergic Signaling in Health and Disease$93037701 997 $aUNINA