LEADER 02703nam  2200469z- 450 
001 9910557221103321
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035   $a(CKB)5400000000041733
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73730
035   $a(oapen)doab73730
035   $a(EXLCZ)995400000000041733
100   $a20202111d2020      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aVitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions
210   $cFrontiers Media SA$d2020
215   $a1 online resource (86 p.)
311 08$a2-88963-578-3 
330   $aThere is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases.
606   $aEndocrinology$2bicssc
606   $aMedicine and Nursing$2bicssc
610   $a1
610   $a25-dihydroxyvitamin D
610   $abioavailable 25-hydroxyvitamin D
610   $afree 25-hydroxyvitamin D
610   $atotal 25-hydroxyvitamin D
610   $avitamin D binding protein
615  7$aEndocrinology
615  7$aMedicine and Nursing
700   $aDavid Bikle$b Daniel$4edt$01278459
702   $aXie$b Zhongjian$4edt
702   $aWang$b Xiangbing$4edt
702   $aDavid Bikle$b Daniel$4oth
702   $aXie$b Zhongjian$4oth
702   $aWang$b Xiangbing$4oth
906   $aBOOK
912   $a9910557221103321
996   $aVitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions$93013294
997   $aUNINA