LEADER 04166nam 2200973z- 450 001 9910557146703321 005 20231214133457.0 035 $a(CKB)5400000000040591 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68616 035 $a(EXLCZ)995400000000040591 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBioinorganic Chemistry of Nickel 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (238 p.) 311 $a3-03928-066-X 311 $a3-03928-067-8 330 $aThe chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology. 606 $aResearch & information: general$2bicssc 610 $aInrS 610 $anickel-dependent transcriptional regulators 610 $amolecular modelling 610 $anickel 610 $ahydrogenase 610 $aurease 610 $aNi-enzymes 610 $apathogens 610 $ancRNA 610 $amiRNA 610 $alncRNA 610 $alung carcinogenesis 610 $ahistidine-rich protein 610 $acarbon monoxide dehydrogenase 610 $anickel chaperone 610 $anickel-induced oligomerization 610 $aurease maturation 610 $ametallochaperone 610 $aG-protein 610 $aconformational change 610 $abioavailability 610 $acarcinogenicity 610 $agenotoxicity 610 $aallergy 610 $areproductive 610 $aasthma 610 $ananoparticles 610 $aecotoxicity 610 $aenvironment 610 $abiological nickel sites 610 $anickel-thiolates 610 $adinuclear nickel metallopeptides 610 $athiolate oxidative damage 610 $anickel enzymes 610 $areaction mechanism 610 $aquantum chemical calculations 610 $aglyoxalase 610 $astreptomyces 610 $amycothiol 610 $ametalloenzyme 610 $aAD11 610 $anickel-dependent enzyme 610 $amethionine salvage pathway 610 $amethionine 610 $aS-adenosylmethionine (SAM) 610 $amethylthioadenosine (MTA) 610 $aenolase phosphatase 1 (ENOPH1) 610 $apolyamine 610 $amatrix metalloproteinase MT1 (MT1-MMP) 610 $ametalloregulator 610 $achaperone 610 $a[NiFe]-hydrogenase 615 7$aResearch & information: general 700 $aMaroney$b Michael J$4edt$01313319 702 $aCiurli$b Stefano$4edt 702 $aMaroney$b Michael J$4oth 702 $aCiurli$b Stefano$4oth 906 $aBOOK 912 $a9910557146703321 996 $aBioinorganic Chemistry of Nickel$93031282 997 $aUNINA