LEADER 04464nam  2201117z- 450 
001 9910557141203321
005 20210501
035   $a(CKB)5400000000040647
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68554
035   $a(oapen)doab68554
035   $a(EXLCZ)995400000000040647
100   $a20202105d2021      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aSample Preparation in Metabolomics
210   $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021
215   $a1 online resource (208 p.)
311 08$a3-03943-813-1 
311 08$a3-03943-814-X 
330   $aMetabolomics is increasingly being used to explore the dynamic responses of living systems in biochemical research. The complexity of the metabolome is outstanding, requiring the use of complementary analytical platforms and methods for its quantitative or qualitative profiling. In alignment with the selected analytical approach and the study aim, sample collection and preparation are critical steps that must be carefully selected and optimized to generate high-quality metabolomic data. This book showcases some of the most recent developments in the field of sample preparation for metabolomics studies. Novel technologies presented include electromembrane extraction of polar metabolites from plasma samples and guidelines for the preparation of biospecimens for the analysis with high-resolution ? magic-angle spinning nuclear magnetic resonance (HR-?MAS NMR). In the following chapters, the spotlight is on sample preparation approaches that have been optimized for diverse bioanalytical applications, including the analysis of cell lines, bacteria, single spheroids, extracellular vesicles, human milk, plant natural products and forest trees.
606   $aMedicine and Nursing$2bicssc
610   $a20% FCS
610   $aAMOPLS
610   $aAsPC-1
610   $abiomarkers
610   $acapillary electrophoresis-mass spectrometry
610   $acapillary electrophoresis-mass spectrometry (CE-MS)
610   $acardiovascular disease
610   $acell line
610   $adatabases
610   $adesign of experiments
610   $adiagnostics
610   $adrug discovery
610   $aelectromembrane extraction
610   $aexosomes
610   $aextracellular vesicles
610   $aextraction
610   $aforestry
610   $agas chromatography
610   $agas chromatography-mass spectrometry (GC-MS)
610   $aGC-MS
610   $aharvesting
610   $ahigh resolution mass spectrometry
610   $ahigh-resolution magic angle spinning
610   $ahuman cell line
610   $ahuman milk
610   $ahuman plasma
610   $ahydrophilic interaction liquid chromatography
610   $aion mobility spectrometry
610   $aIT-139
610   $aKP1339
610   $aLC-MS
610   $aLC-MS/MS
610   $alipidomics
610   $aliquid chromatography
610   $aliquid chromatography-mass spectrometry
610   $aliquid chromatography-mass spectrometry (LC-MS)
610   $amass spectrometry
610   $ametabolic pathways
610   $ametabolic profiling
610   $ametabolite extraction
610   $ametabolites
610   $ametabolome
610   $ametabolomics
610   $ametabonomics
610   $ametadata standardization
610   $ametallodrugs
610   $amethod development
610   $aMiaPaCa-2
610   $amicroscopic samples
610   $amicrovesicles
610   $amulti-segment injection
610   $amulticellular tumor spheroids
610   $aNMR
610   $anormalization
610   $anuclear magnetic resonance (NMR)
610   $anuclear magnetic resonance spectroscopy
610   $aoxaliplatin
610   $aPanc-1
610   $aplant metabolomics
610   $aplant natural products
610   $asample preparation
610   $asampling
610   $atrees
615  7$aMedicine and Nursing
700   $aKuligowski$b Julia$4edt$01302968
702   $aQuintás$b Guillermo$4edt
702   $aKuligowski$b Julia$4oth
702   $aQuintás$b Guillermo$4oth
906   $aBOOK
912   $a9910557141203321
996   $aSample Preparation in Metabolomics$93026786
997   $aUNINA