LEADER 04028nam 2200961z- 450 001 9910557129803321 005 20231214133245.0 035 $a(CKB)5400000000040756 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68311 035 $a(EXLCZ)995400000000040756 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aClay-Based Pharmaceutical Formulations and Drug Delivery Systems 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (202 p.) 311 $a3-0365-0186-X 311 $a3-0365-0187-8 330 $aThis book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design. 606 $aMedicine$2bicssc 610 $ahydrochlorothiazide 610 $acyclodextrins 610 $asepiolite 610 $ananoclay 610 $adissolution rate 610 $atablet 610 $aelectrospinning 610 $achitosan 610 $achondroitin sulfate 610 $ascaffolds 610 $amontmorillonite 610 $ahalloysite 610 $afibroblasts proliferation 610 $aimmune response 610 $aglycosaminoglycans 610 $aantimicrobial properties 610 $apalygorskite 610 $aspring water 610 $ahydrogel 610 $afibroblast 610 $abiocompatibility 610 $awound healing 610 $amesoporous clay 610 $aNeusilin 610 $aaeroperl 610 $aliquisolid technique 610 $aglyburide 610 $adissolution improvement 610 $ahydrotalcite 610 $aketoprofen 610 $ahybrid 610 $aphotostability 610 $ahydrogel film 610 $abioadhesion 610 $aheavy metal 610 $ahazardous element 610 $aelement mobility 610 $aclay minerals 610 $atoxicity 610 $apalygorksite 610 $aproliferation 610 $aFranz cell 610 $abioactive elements 610 $apraziquantel 610 $adrug 610 $aorganic solvents 610 $ain vitro dissolution tests 610 $acytotoxicity 610 $atargeted drug delivery 610 $ahalloysite nanotube 610 $aosteosarcoma 610 $amethotrexate 610 $asurface modification 615 7$aMedicine 700 $aViseras$b Ce?sar$4edt$01290169 702 $aViseras$b Ce?sar$4oth 906 $aBOOK 912 $a9910557129803321 996 $aClay-Based Pharmaceutical Formulations and Drug Delivery Systems$93021381 997 $aUNINA