LEADER 04454nam 2201033z- 450 001 9910557128603321 005 20210501 035 $a(CKB)5400000000040768 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68549 035 $a(oapen)doab68549 035 $a(EXLCZ)995400000000040768 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRefinements to Animal Models for Biomedical Research 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (234 p.) 311 08$a3-0365-0332-3 311 08$a3-0365-0333-1 330 $aThere is some talk about an antibiotic Armageddon, wherein untreatable post-operative infections and similarly untreatable complications after chemotherapy will occur. The now famous "O'Neill Report" suggests that, by 2050, more people could die from resistant bacterial infections than from cancer. We are still learning about all the subtle drivers of antibiotic resistance, realizing that we need a single "whole health" coordinated policy. We ingest what we sometimes feed to animals, yet there does not seem to be any new classes of antibiotics on the horizon. Maybe there is something that has been around forever that could could to our rescue: bacteriophages. Nevertheless, we have to do things differently. We must use antibiotics appropriately and for the correct indication, duration, and dosage with good practice and stewardship.. While by no means comprehensive, this book covers many topics regarding antibiotic stewardship. It also addresses older antibiotics, new combinations, and even new agents. Last but not least, this book features two excellent articles on bacteriophages. Refinements to animal models used in research for either human or animal benefit must be an ongoing aim for anyone working in this context, whether it be as an animal carrier, an animal user, a veterinarian, or an official. Unfortunately, the details of refinements are often overlooked in publications describing the research outcomes. This book includes manuscripts published in the Animals Special Issue "Refinements to Animal Models for Biomedical Research". In this contemporary resource, we included 12 peer-reviewed papers that cover a range of approaches to the concept of refinement. 606 $aBiology, life sciences$2bicssc 606 $aResearch and information: general$2bicssc 610 $a3R principles 610 $aanaesthesia 610 $aanalgesia 610 $aanimal research 610 $aanimal testing 610 $abehaviour 610 $abiomedical research 610 $ablood sample 610 $acalves 610 $acamel 610 $acaptive bolt 610 $acastration 610 $acat 610 $aCavia porcellus 610 $acytokines 610 $adisbudding 610 $adog 610 $afacial expressions 610 $afunctional MRI 610 $agene transcription 610 $agrimace scales 610 $agrimace scores 610 $aguinea pig 610 $ahealth 610 $ahistory of science 610 $ahorse 610 $ahumane euthanasia 610 $ahumane killing 610 $alaboratory animal 610 $alaboratory animals 610 $ameloxicam 610 $amice 610 $amouse 610 $an/a 610 $anCounter 610 $aneonate 610 $anociception 610 $anociceptive threshold 610 $apain 610 $apain assessment 610 $aperi-operative 610 $apiglet 610 $apostoperative analgesia 610 $apreclinical research 610 $arabbit 610 $arat 610 $arat anaesthesia 610 $arefinement 610 $aretrobulbar 610 $asheep 610 $asublingual 610 $asubmandibular 610 $asurvey 610 $atransdermal fentanyl patch 610 $avocalisation 610 $awell-being 615 7$aBiology, life sciences 615 7$aResearch and information: general 700 $aMusk$b Gabrielle$4edt$01296137 702 $aMusk$b Gabrielle$4oth 906 $aBOOK 912 $a9910557128603321 996 $aRefinements to Animal Models for Biomedical Research$93023797 997 $aUNINA