LEADER 03104nam 2200601z- 450 001 9910557124503321 005 20210501 035 $a(CKB)5400000000040809 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68296 035 $a(oapen)doab68296 035 $a(EXLCZ)995400000000040809 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aJuvenile Onset Huntington's Disease 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (102 p.) 311 08$a3-03943-811-5 311 08$a3-03943-812-3 330 $aThe Special Issue "Juvenile Onset Huntington's Disease" highlights the growing interest in understanding the unique aspects of this ultra-rare disorder. After decades of research, gene therapy trials are underway for Adult Onset Huntington's Disease (AOHD). However, patients with Juvenile Onset Huntington's Disease (JOHD) are often excluded from these efforts, leaving many questions regarding its phenomenology. The current issue includes seven articles spanning work on the difficult emotional experiences of parents of children with JOHD; a review of the clinical manifestations of JOHD; behavioral issues in JOHD; CAG repeat and age of motor onset; autonomic nervous system dysfunction; and abnormality in MRI metabolic markers. Finally, a review of the therapeutic advances is included, highlighting future possibilities of clinical trials in JOHD subjects. The HD community-patients, family members at-risk for HD, caregivers, health-care professionals and scientists-is keen on expanding our understanding of JOHD. In the flurry of research on AOHD, those with JOHD were seemingly 'left behind.' The study of patients who are afflicted early in life with HD has become imperative, with this Special Issue representing just the beginning of the required effort to address this urgent need. 606 $aMedicine and Nursing$2bicssc 610 $aautonomic 610 $abehavioral regulation 610 $aCAG 610 $aCAG repeat 610 $acaregivers 610 $acase series 610 $aearly-onset Huntington's disease 610 $aexecutive function 610 $aHuntington's disease 610 $ajuvenile Huntington's disease 610 $ajuvenile-onset Huntington's disease 610 $ajuvenile-onset Huntington's Disease 610 $amotor onset 610 $amutant huntingtin (mHTT) 610 $an/a 610 $aneurodegeneration 610 $aneuroimaging 610 $apediatric Huntington's disease 610 $apersonal experiences 610 $aT1-Rho 610 $atherapeutics 610 $atrinucleotide repeat disorder 615 7$aMedicine and Nursing 700 $aNopoulos$b Peggy C$4edt$01303358 702 $aNopoulos$b Peggy C$4oth 906 $aBOOK 912 $a9910557124503321 996 $aJuvenile Onset Huntington's Disease$93026942 997 $aUNINA