LEADER 03949nam 2200829z- 450 001 9910557124303321 005 20231214133315.0 035 $a(CKB)5400000000040811 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68356 035 $a(EXLCZ)995400000000040811 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aThe Effect of Calorie Restriction and Intermittent Fasting on Health and Disease 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (186 p.) 311 $a3-03943-837-9 311 $a3-03943-838-7 330 $aRecent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer?s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, ?The effects of calorie restriction and intermittent fasting on health and disease?, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aFood & society$2bicssc 610 $acalorie restriction diet 610 $abody mass reduction 610 $ainsulin 610 $aIGF-1 610 $aleptin 610 $aadiponectin 610 $amalnutrition 610 $aheart impairment 610 $apapillary muscle assay 610 $acalcium transient proteins 610 $aSERCA2a 610 $aL-type calcium channel 610 $aaging 610 $aautophagy 610 $acalorie restriction (CR) 610 $aCR mimetic 610 $acalorie restriction 610 $aFoxO transcription factor 610 $asirtuin 610 $aneuropeptide Y 610 $apleiotropy of CR genes 610 $asenescence-associated secretory phenotype 610 $asenoinflammation 610 $amimetics 610 $aintermittent fasting 610 $afat mass 610 $ainsulin secretion 610 $apancreatic islet 610 $alifespan 610 $alongevity 610 $afasting 610 $askin aging 610 $aphotoaging 610 $askin appendages 610 $acaloric restriction 610 $afatty acid biosynthesis 610 $amitochondrial biogenesis 610 $aadipocyte 615 7$aResearch & information: general 615 7$aBiology, life sciences 615 7$aFood & society 700 $aChung$b Hae-Young$4edt$01302967 702 $aChung$b Hae-Young$4oth 906 $aBOOK 912 $a9910557124303321 996 $aThe Effect of Calorie Restriction and Intermittent Fasting on Health and Disease$93026785 997 $aUNINA