LEADER 03900nam 2201201z- 450 001 9910566469503321 005 20220506 035 $a(CKB)5680000000037685 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81213 035 $a(oapen)doab81213 035 $a(EXLCZ)995680000000037685 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTargeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (298 p.) 311 08$a3-0365-3517-9 311 08$a3-0365-3518-7 330 $aDysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers which discuss the role of Wnt signaling and associated targets in cancer metabolism, tumor immune response, and tumor microenvironment. Papers discussing a range of Wnt-mediated cancers, including those of the colon, liver, pancreas, synovium, bladder, etc., are included. 517 $aTargeting Wnt Signaling in Cancer 606 $aMedicine and Nursing$2bicssc 606 $aPharmacology$2bicssc 610 $aAML 610 $aangiogenesis 610 $aanti-angiogenic therapy 610 $aAPC 610 $aastrocytic brain tumors 610 $acancer 610 $acancer stem cells 610 $acancer therapy 610 $aCBP 610 $acell adhesion 610 $acolitis 610 $acolon cancer 610 $acolorectal 610 $acolorectal cancer 610 $aDKKs 610 $adrug discovery 610 $adrug target 610 $aEMT 610 $afibrosis 610 $afungi secondary metabolite derivative 610 $agastrointestinal cancers 610 $aGSK3? 610 $aHBV 610 $ahepatitis B virus 610 $aIBD 610 $aimmune checkpoint inhibitor 610 $aimmunotherapy 610 $aimmunotherapy resistance 610 $ainvasion and metastasis 610 $ajust-right signaling 610 $aL1 610 $aLgr5 610 $aliver cancer 610 $amicroenvironment 610 $amolecular targeting 610 $amolecular therapeutics 610 $aMusashi 610 $aMYC 610 $aNCB-0846 610 $aNF-?B 610 $aNotch signaling 610 $ap300 610 $apancreatic cancer 610 $apancreatic stellate cells 610 $apancreatitis 610 $aporcupine 610 $aprecision medicine 610 $aR-spondin 610 $aRNA-binding proteins 610 $aserrated 610 $asignaling 610 $asynovial sarcoma 610 $aTCF/LEF 610 $atherapeutic targeting of Wnt signaling 610 $aTNIK 610 $atumor immunology 610 $atumor metabolism 610 $aurothelial cancer 610 $avitamin D 610 $awnt 610 $aWnt 610 $aWnt signaling 610 $aWnt target genes 610 $aWnt/beta-catenin signaling 610 $a?-catenin 610 $a?-catenin mutations 610 $a?-catenin paradox 615 7$aMedicine and Nursing 615 7$aPharmacology 700 $aKahn$b Michael$4edt$01310152 702 $aLai$b Keane$4edt 702 $aKahn$b Michael$4oth 702 $aLai$b Keane$4oth 906 $aBOOK 912 $a9910566469503321 996 $aTargeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles$93040916 997 $aUNINA LEADER 04316nam 2201117z- 450 001 9910557123303321 005 20260106202446.0 035 $a(CKB)5400000000040821 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68543 035 $a(oapen)doab68543 035 $a(EXLCZ)995400000000040821 100 $a20202105d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNatural Fibres and their Composites 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (252 p.) 311 08$a3-0365-0164-9 311 08$a3-0365-0165-7 330 $aOver the last decades, natural fibers have received growing attention as alternatives to synthetic materials for the reinforcement of polymeric composites. Their specific properties, low price, health advantages, renewability and recyclability make natural fibers particularly attractive for these purposes. Furthermore, natural fibers have a CO2-neutral life cycle, in contrast to their synthetic counterparts. However, natural fibers are also widely known to possess several drawbacks, such as a hydrophilic nature, low and variable mechanical properties, poor adhesion to polymeric matrices, high susceptibility to moisture absorption and low aging resistance. Therefore, extensive research has been conducted on natural fiber-reinforced composites in the last 20 years. In this context, this book presents several interesting papers concerning the use of natural fibers for the reinforcement of polymer-based composites, with a focus on the evaluation of their mechanical performances, ballistic properties, rheological behavior, thermal insulation response and aging resistance in humid or aggressive environments. 606 $aResearch & information: general$2bicssc 610 $aadhesion 610 $aballistic performance 610 $abasalt fibers 610 $abasalt FRP 610 $abending 610 $abiobased composite 610 $abiocomposite 610 $acharacterizations 610 $acoaxial electrospinning 610 $acomposite laminate 610 $acomposite laminates 610 $acuraua fibers 610 $adelamination 610 $adiffusion 610 $adog wool fibers 610 $aeco-composites 610 $aelastic behaviour 610 $aempty fruit bunch fiber (EFB) 610 $aepoxy composites 610 $afillers 610 $afique fibers 610 $aflax fiber 610 $aflax fibers 610 $aflax FRP 610 $aflexural 610 $aglass FRP 610 $aglycerol 610 $agraphene oxide coating 610 $ahybrid FRP 610 $ahygrothermal properties 610 $aimpact damage 610 $aleather waste 610 $alength of straight fluid jet 610 $alinear relationship 610 $alow-velocity impact 610 $amechanical characterization 610 $amechanical properties 610 $amicromechanics 610 $aMopa-Mopa resin 610 $an/a 610 $anano-clay 610 $ananoribbons 610 $anatural fibre composites 610 $aplasticizer migration 610 $apoly(butylene succinate) 610 $apoly(lactic acid) 610 $apolybutylene succinate (PBS) 610 $apolymer Blends 610 $apolymer matrix composites 610 $apolymer-matrix composites (PMCs) 610 $apolypropylene 610 $apolyurethane 610 $arecycled cotton fibers 610 $arenewable resources 610 $aspreading angle 610 $astarch 610 $astiffness 610 $asurface treatments 610 $athermal characterization 610 $athermoplastic starch 610 $aviscous response 610 $awater uptake 610 $awood beam 610 $awood-plastic 610 $aX-ray micro CT 610 $aYoung's modulus 615 7$aResearch & information: general 702 $aFiore$b Vincenzo$c(Professor of engineering)$4oth 906 $aBOOK 912 $a9910557123303321 996 $aNatural Fibres and their Composites$94520256 997 $aUNINA