LEADER 05457nam 2201501z- 450 001 9910557114803321 005 20210501 035 $a(CKB)5400000000040898 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69028 035 $a(oapen)doab69028 035 $a(EXLCZ)995400000000040898 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aActinomycetes$eThe Antibiotics Producers 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (362 p.) 311 08$a3-03936-910-5 311 08$a3-03936-911-3 330 $aBeyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes 517 $aActinomycetes 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $a(p)ppGpp 610 $aA40926 610 $aActinoallomurus 610 $aactinobacteria 610 $aActinobacteria 610 $aactinomycetes 610 $aacyltransferases 610 $aAmycolatopsis 610 $aantibiotic 610 $aantibiotics 610 $aantibiotics polyethers 610 $aaromatic polyketide 610 $abenz[a]naphthacene quinone 610 $abiogeography 610 $abiological activity 610 $abiosynthesis 610 $abiosynthetic gene cluster 610 $aCave microbiology 610 $achemical ecology 610 $acomparative genomics 610 $aculture-based approaches 610 $acyclases 610 $adalbavancin 610 $adbv cluster 610 $adereplication 610 $adifferentiation 610 $adiversification 610 $adrug discovery 610 $aelicitors 610 $aengineering 610 $aextended polyketide chain 610 $aFK506 610 $agenome mining 610 $ageomicrobiology 610 $aglycopeptide antibiotics 610 $aIllumina sequencing 610 $aLAL 610 $aliquid cultures 610 $aLuxR solo 610 $alysolipin 610 $ametabolomics 610 $ametagenomics 610 $amicrobiome diversity 610 $aminimal PKS II 610 $amorphology 610 $an/a 610 $anatural products 610 $anew bioactive compounds 610 $anovel compounds 610 $aomics 610 $apentacyclic angular polyphenol 610 $aphysical and chemical properties 610 $aphysicochemical screening 610 $apolyadenylation 610 $apolyketide synthases 610 $apolyketides 610 $apolynucleotide phosphorylase 610 $apromoter 610 $arare Actinobacteria 610 $arare actinomycetes 610 $aregulation 610 $aregulatory genes 610 $aresistance 610 $aribonuclease 610 $arishirilide 610 $aRNA decay 610 $ascreening 610 $asecondary metabolism 610 $asecondary metabolite 610 $asecondary metabolite biosynthetic gene clusters 610 $asecondary metabolites 610 $asecretion pathways 610 $asecretory proteins 610 $asiderophore 610 $asignal peptides 610 $aSMGC 610 $aspecialized metabolites 610 $astrain 610 $astreptomyces 610 $aStreptomyces 610 $aStreptomyces lividans 610 $aStreptomyces tsukubaensis 610 $aStrR 610 $astructural diversity 610 $asymbiosis 610 $atacrolimus 610 $ateicoplanin 610 $atridecaketide 610 $aunculturability 610 $avan resistance genes 610 $a?-lactamase 610 $a?-lactamase inhibitor 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $aStegmann$b Evi$4edt$01294099 702 $aMast$b Yvonne$4edt 702 $aStegmann$b Evi$4oth 702 $aMast$b Yvonne$4oth 906 $aBOOK 912 $a9910557114803321 996 $aActinomycetes$93022869 997 $aUNINA