LEADER 05216nam 2201285z- 450 001 9910557113303321 005 20231214133630.0 035 $a(CKB)5400000000040913 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69246 035 $a(EXLCZ)995400000000040913 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdipose-Derived Stromal/Stem Cells 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (286 p.) 311 $a3-03943-282-6 311 $a3-03943-283-4 330 $aAdipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells. 606 $aMedicine$2bicssc 610 $alipomas 610 $aadipose tissue 610 $astem cells 610 $aadipogenesis 610 $aosteogenesis 610 $amesenchymal stem cells 610 $aT-cells 610 $aconditioned medium 610 $aextracellular vesicles 610 $aTLR 610 $aINF-? 610 $aadipose-derived stromal cells 610 $aequine metabolic syndrome 610 $ametformin 610 $aadipose-derived stem cells 610 $aadipocytes 610 $adifferentiation 610 $acollagen I 610 $aadiponectin 610 $aintegrins 610 $adiscoidin domain-containing receptor 610 $aageing 610 $asubcutaneous fat 610 $aadipose tissue-derived mesenchymal stromal/stem cells (ASCs) 610 $acell differentiation 610 $avolatile organic compounds 610 $ametabolic monitoring 610 $aadipose-derived stromal/stem cells 610 $achondrogenesis 610 $acolony forming unit-fibroblast 610 $afetal bovine serum 610 $ahuman platelet lysate 610 $amesenchymal stem cell 610 $aregenerative medicine 610 $ahuman adipose-derived stem cells 610 $astem cell proliferation 610 $asignaling pathway 610 $aadipose-derived mesenchymal stem cells 610 $amigration 610 $asecretion 610 $aprimary cilium 610 $asonic hedgehog signaling 610 $amesenchymal stromal/stem cells 610 $aperirenal 610 $afat 610 $acharacterization 610 $astimulation 610 $alipopolysaccharide 610 $acytokines 610 $acytomegalovirus 610 $aangiogenesis 610 $aadipose derived mesenchymal cells 610 $aHistogel 610 $a3D cell culture 610 $aspheroid culture 610 $abiomaterials 610 $aphenotype 610 $asecretory potential 610 $aankylosing spondylitis 610 $asystemic lupus erythematosus 610 $asystemic sclerosis 610 $amesenchymal stromal cells 610 $abreast cancer 610 $atumor microenvironment 610 $aperineural invasion 610 $aadipose derived stem cells 610 $avalproic acid 610 $aprotein interactions 610 $aMAPK pathway 610 $aJAK/STAT pathway 610 $amesenchymal stromal cell 610 $atissue of origin 610 $aprolonged culture 610 $aepigenetic memory 610 $atracking 610 $abio imaging 610 $abioluminescence 610 $aqRT-PCR 610 $aAtaxia telangiectasia 610 $aAtm 615 7$aMedicine 700 $aBaer$b Patrick C$4edt$01293413 702 $aBaer$b Patrick C$4oth 906 $aBOOK 912 $a9910557113303321 996 $aAdipose-Derived Stromal$93022595 997 $aUNINA