LEADER 03793nam 2200901z- 450 001 9910557110203321 005 20231214132849.0 035 $a(CKB)5400000000040945 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69057 035 $a(EXLCZ)995400000000040945 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPeptide Nucleic Acids$eApplications in Biomedical Sciences 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (154 p.) 311 $a3-03936-886-9 311 $a3-03936-887-7 330 $aThis book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents. 517 $aPeptide Nucleic Acids 606 $aMedicine$2bicssc 610 $aRNA structure 610 $astrand invasion 610 $aantisense 610 $aPNA 610 $aexon skipping 610 $aexon inclusion 610 $aoligonucleotides 610 $apeptide nucleic acid (PNA) 610 $aantibacterials 610 $aRNA 610 $aPNA transporters 610 $aconjugates 610 $abacterial resistance 610 $apeptide nucleic acids 610 $atriplex 610 $agene editing 610 $astructure 610 $arecombination 610 $arepair 610 $ananoparticles 610 $a?-thalassemia 610 $acystic fibrosis 610 $apeptide nucleic acid 610 $atolane 610 $asingle nucleotide polymorphism 610 $ainfluenza virus 610 $adrug resistance 610 $apeptide nucleic acids (PNAs) 610 $asingle-nucleotide polymorphism (SNP) 610 $apolymerase chain reaction (PCR) 610 $acancer. 610 $acatalytic hairpin assembly (CHA) 610 $astrand-displacement reaction 610 $al-DNA 610 $amicroRNA 610 $afluorescence 610 $atemplated reactions 610 $alight-triggered 610 $aelectrochemical biosensors 610 $acolorimetric detection 610 $aPeptide nucleic acids 610 $aPNA-masking 610 $amicroRNAs 610 $amiR-145-5p 610 $amiRNA targeting 610 $adelivery 610 $aCFTR 615 7$aMedicine 700 $aYavin$b Eylon$4edt$01290288 702 $aYavin$b Eylon$4oth 906 $aBOOK 912 $a9910557110203321 996 $aPeptide Nucleic Acids$93021451 997 $aUNINA