LEADER 06493nam 2201861z- 450 001 9910557109003321 005 20210501 035 $a(CKB)5400000000040957 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69265 035 $a(oapen)doab69265 035 $a(EXLCZ)995400000000040957 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBotulinum Neurotoxins and Nervous System$eFuture Challenges for Novel Indications 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (368 p.) 311 08$a3-03943-456-X 311 08$a3-03943-457-8 330 $aThis book collects 25 scientific articles from laboratories around the world, all of which use botulinum neurotoxins as the main protagonists of their studies. The use of botulinum neurotoxin in medicine, following its ability to inhibit the effects of various disorders of different etiology on the human organism, constitutes the main topic of each article presented here. This book, which is aimed at both students and medical professionals, attempts to summarize current knowledge about the use of botulinum toxin as a therapeutic agent in many diseases, ranging from spasticity to tremor, form motor dysfunction after stroke to neuropathic pain, from hyperactive muscle to migraine, and so on. Thanks to its simplified writing, accessible to an audience who may not be familiar with the mysteries of science, readers will get new insights into this biological toxin and its multiple applications, not simply relegated to its historical use to correct of face wrinkles. Both review and research articles are presented, not only concerning animal studies, but also clinical reports. This book will provide an up-to-date picture of the state-of-the-art of the possible development of novel applications of botulinum neurotoxins for future therapeutic purposes. 517 $aBotulinum Neurotoxins and Nervous System 606 $aMedicine$2bicssc 610 $aabobotulinumtoxinA 610 $aallodynia 610 $aantipruritic 610 $aappropriate treatment 610 $aastroglia 610 $abasal ganglia 610 $abiological effect 610 $aBoNT/A 610 $abotulinum antitoxin 610 $abotulinum neurotoxin 610 $abotulinum neurotoxin serotype A 610 $abotulinum neurotoxin serotype a heavy chain (BoNT/A HC) 610 $abotulinum neurotoxin-A 610 $abotulinum neurotoxins 610 $abotulinum toxin 610 $aBotulinum toxin 610 $abotulinum toxin A 610 $abotulinum toxin therapy 610 $abotulinum toxin type A 610 $aBTX 610 $acentral neuropathic pain 610 $acerebral palsy 610 $achloroquine 610 $achronic pelvic pain 610 $aclinical 610 $aclinical decision support 610 $aclinical trial 610 $aClostridium tetani 610 $acomplex regional pain syndrome 610 $acompound 48/80 610 $adelivery 610 $adental occlusion 610 $adermatology 610 $adiagnostic guidance 610 $adrooling 610 $adystonic tremor 610 $aearly use 610 $aeccrine glands 610 $aelectrical activity 610 $aelectrical stimulation 610 $aelectromyography 610 $aepilepsy 610 $aessential tremor 610 $aexperimental 610 $afood safety 610 $aformulation 610 $aglia 610 $agrowth associated protein 43 (GAP-43) 610 $ahand 610 $ahand tremor 610 $aheavy chain 610 $ahuman 610 $aimmunohistochemistry 610 $aincobotulinumtoxin A 610 $ainterleukins 610 $ainterneurons 610 $ainterspecies differences in motor behavior 610 $aitch 610 $ajoint biomechanics 610 $akinematics 610 $alateral pterygoid muscle 610 $alimb tremors 610 $alumbar sympathetic ganglion block 610 $amast cells 610 $amasticatory system 610 $amaxillofacial bone 610 $amedication overuse headache 610 $amicroglia 610 $amouse 610 $amouse test 610 $amovement disorders 610 $amuscle selection 610 $an/a 610 $anerve regeneration 610 $aneural regeneration 610 $aneuronal processes 610 $aneurotransmission blockade 610 $aneurotransmitter 610 $anew indications 610 $anovel indication 610 $aonabotulinumtoxin A 610 $aONTIME 610 $aorthognathic surgery 610 $aoveractive detrusor 610 $apain 610 $aParkinson's disease 610 $apost-stroke 610 $apost-stroke shoulder pain 610 $aprion disease 610 $aprophylactic treatment 610 $apruritus 610 $arat 610 $arefractory chronic migraine 610 $arehabilitation 610 $asalivary glands 610 $aSchwann cells 610 $asciatic static index 610 $asialorrhoea 610 $aSnap-23 610 $aSNAP-25 610 $aSNARE 610 $aspastic paresis 610 $aspasticity 610 $aspinal cord 610 $aspinal cord injury 610 $aspinal cord injury (SCI) 610 $astroke management 610 $asuperior cervical ganglion 10 (SCG10) 610 $aswallowing 610 $asynaptic transmission 610 $atemporomandibular joint dislocation 610 $atension headache 610 $aTherapeutic Index 610 $aTLR2 610 $aTLR4 610 $atreatment 610 $atremor 610 $aupper limb biomechanics 610 $aupper limb spasticity 610 $aurodynamics 610 $avaginism 610 $aVAMP 610 $avarious cell types 610 $awalking track analysis 610 $aweight bearing 610 $aXEOMINŽ 615 7$aMedicine 700 $aLuvisetto$b Siro$4edt$01318437 702 $aLuvisetto$b Siro$4oth 906 $aBOOK 912 $a9910557109003321 996 $aBotulinum Neurotoxins and Nervous System$93033246 997 $aUNINA