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035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69370
035   $a(oapen)doab69370
035   $a(EXLCZ)995400000000040975
100   $a20202105d2020      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$amTOR Signaling in Metabolism and Cancer
210   $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020
215   $a1 online resource (204 p.)
311 08$a3-03943-553-1 
311 08$a3-03943-554-X 
330   $aThe mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases.
606   $aMedicine$2bicssc
610   $aAcute Lymphoblastic leukemia
610   $aadhesion
610   $aAkt
610   $abasal cell carcinoma
610   $abiomarkers
610   $acancers
610   $acell metabolism
610   $acell signalling
610   $aclinical trials
610   $acombination
610   $aeribulin
610   $aeverolimus
610   $aFoxp3
610   $ahead and neck cancer
610   $ahematologic malignancies
610   $ahistone deacetylase
610   $ainhibitors
610   $aintegrins
610   $aintestine
610   $ainvasion
610   $aliver
610   $amelanoma
610   $aMerkel cell carcinoma
610   $ametabolism
610   $amTOR
610   $amTOR signaling
610   $amTOR signalling
610   $amuscle
610   $amutant genes
610   $aneuron
610   $aphotodynamic therapy
610   $aphytochemicals
610   $aPI3K
610   $aPI3K/AKT/mTOR
610   $aprostate cancer
610   $aregulatory T cells
610   $askin cancers
610   $asquamous cell carcinoma
610   $asynergy
610   $aT cells
610   $atargeted therapies
610   $atargeted therapy
610   $atissue regeneration
610   $aTNBC
610   $atumor
615  7$aMedicine
700   $aHuang$b Shile$4edt$01325337
702   $aHuang$b Shile$4oth
906   $aBOOK
912   $a9910557107203321
996   $aMTOR Signaling in Metabolism and Cancer$93036762
997   $aUNINA