LEADER 03014nam 2200865z- 450 001 9910557107203321 005 20231214132928.0 035 $a(CKB)5400000000040975 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69370 035 $a(EXLCZ)995400000000040975 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$amTOR Signaling in Metabolism and Cancer 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (204 p.) 311 $a3-03943-553-1 311 $a3-03943-554-X 330 $aThe mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases. 606 $aMedicine$2bicssc 610 $amTOR 610 $ahistone deacetylase 610 $aprostate cancer 610 $aintegrins 610 $aadhesion 610 $ainvasion 610 $acell metabolism 610 $aT cells 610 $aFoxp3 610 $aAcute Lymphoblastic leukemia 610 $atargeted therapy 610 $ametabolism 610 $acell signalling 610 $amTOR signalling 610 $ahead and neck cancer 610 $amutant genes 610 $abiomarkers 610 $atargeted therapies 610 $aclinical trials 610 $acancers 610 $ainhibitors 610 $aphotodynamic therapy 610 $aPI3K 610 $aAkt 610 $askin cancers 610 $aphytochemicals 610 $amelanoma 610 $abasal cell carcinoma 610 $asquamous cell carcinoma 610 $aMerkel cell carcinoma 610 $aTNBC 610 $aeribulin 610 $aPI3K/AKT/mTOR 610 $aeverolimus 610 $acombination 610 $asynergy 610 $amTOR signaling 610 $atissue regeneration 610 $aneuron 610 $amuscle 610 $aliver 610 $aintestine 610 $ahematologic malignancies 610 $aregulatory T cells 610 $atumor 615 7$aMedicine 700 $aHuang$b Shile$4edt$01325337 702 $aHuang$b Shile$4oth 906 $aBOOK 912 $a9910557107203321 996 $aMTOR Signaling in Metabolism and Cancer$93036762 997 $aUNINA