LEADER 04540nam 2201285z- 450 001 9910557105803321 005 20231214133422.0 035 $a(CKB)5400000000040989 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68966 035 $a(EXLCZ)995400000000040989 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMetastatic Progression and Tumour Heterogeneity 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 electronic resource (312 p.) 311 $a3-03928-853-9 311 $a3-03928-854-7 330 $aImproved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors. 606 $aMedicine$2bicssc 610 $aclear cell renal cell carcinoma 610 $atumor evolution 610 $atumor ecology 610 $aintratumor heterogeneity 610 $amultisite tumor sampling 610 $atargeted therapy 610 $auterine carcinosarcoma 610 $aendometrial carcinoma 610 $ametaplastic carcinoma 610 $aepithelial-to-mesenchymal transition 610 $aclonality 610 $amutation 610 $aTP53 610 $aPI3K/AKT pathway 610 $agene expression 610 $amiRNA expression 610 $atumor microenvironment 610 $ainterstitial pH 610 $aacidosis 610 $atumor heterogeneity 610 $amagnetic resonance imaging 610 $ahyperpolarized 13C MRI 610 $acarbonic anhydrase 610 $alactic acid 610 $apositron emission tomography 610 $aesophageal squamous cell carcinoma 610 $aprecision medicine 610 $anatural killer cells 610 $atumor mutation burden 610 $aimmunotherapy 610 $aPET 610 $aheterogeneity 610 $aradiomics 610 $aradiopharmaceuticals 610 $aSUV 610 $anuclear medicine 610 $acolon cancer 610 $aWnt signaling 610 $aphenotypic plasticity 610 $aEMT 610 $ahybrid E/M 610 $acollective and single-cell migration 610 $abeta-catenin paradox 610 $abreast cancer 610 $aimmune microenvironment 610 $aDCIS 610 $aADH 610 $amammary gland 610 $acell fate 610 $a3D cultures 610 $aorganoids 610 $asignaling 610 $asingle-cell RNAseq 610 $atumor endothelial cell 610 $ametastasis 610 $aangiocrine factor 610 $amicrosatellite instability 610 $acolorectal cancer 610 $aimmune checkpoints 610 $adeficient mismatch repair 610 $aplasticity 610 $abiomechanics 610 $acirculating tumor cells (CTCs) 610 $aextracellular vesicles 610 $ametastatic niche 610 $aepigenetics 610 $aCTC-clusters 610 $asingle-cell analysis 610 $acellular heterogeneity 610 $acirculating tumor cells 610 $apancreatic cancer 610 $aepithelial mesenchymal plasticity 610 $atarget discovery 610 $areview 610 $agenomics 610 $aintra-tumour heterogeneity 610 $asubclonal diversity 610 $atreatment resistance 615 7$aMedicine 700 $aHollande$b Fred$4edt$01327820 702 $aMerino$b Delphine$4edt 702 $aHollande$b Fred$4oth 702 $aMerino$b Delphine$4oth 906 $aBOOK 912 $a9910557105803321 996 $aMetastatic Progression and Tumour Heterogeneity$93038137 997 $aUNINA