LEADER 03511nam 2200421 450 001 9910555146403321 005 20200311164058.0 010 $a1-119-30968-9 010 $a1-119-30967-0 010 $a1-119-30969-7 035 $a(CKB)4330000000010144 035 $a(MiAaPQ)EBC6032028 035 $a(PPN)249108070 035 $a(EXLCZ)994330000000010144 100 $a20200323d2020 uy 0 101 0 $aeng 135 $au||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStructure and function of the bacterial genome /$fCharles J. Dorman 210 1$aHoboken, New Jersey :$cWiley-Blackwell,$d[2020] 210 4$dİ2020 215 $a1 online resource (412 pages) 311 $a1-119-30879-8 327 $aThe bacterial genome : where the genes are -- Conservation and evolution of the dynamic genome -- Gene control : transcription and its regulation -- Gene control : regulation at the RNA level -- Gene control : regulation at the protein level -- Gene control and bacterial physiology -- Gene control : global regulation by H-NS -- An integrated view of genome structure and function. 330 $a"The book aims to integrate information from the very latest research on bacterial chromosome and nucleoid architecture, whole-genome analysis, cell signaling and gene expression control with well-known gene regulation paradigms from model organisms to give the reader a picture of how information flows from the environment to the gene, modulating its expression and influencing the competitive fitness of the microbe. The general public is aware that bacteria can come in benign forms and forms that pose threats to health. This book will explore the governance of the expression of the genes that make a bacterium what it is: a friend or foe to the human/animal/plant host. The reader will learn that the factors that govern the expression of genes by turning them on or off often contribute to the organization of the genetic material within the cell. Our understanding of the architecture of the genome has advanced rapidly in recent years and we are learning more and more about the forces that work to keep genomes the way they are, to change them and the consequences of change for the life of the evolving bacterium. These conservative and disruptive forces will be described, together with their influence on gene expression. The book will also review the basics of gene expression control, bringing the topic up-to-date with information about small RNAs, RNAs that sense chemical signals and the role of DNA as a regulatory factor as well as a carrier of genetic information and will consider where these genes are placed in the core genome and how they are regulated using a combination of imported control proteins and pre-existing ones. The reader will also gain a clearer understanding of the rules that govern microbial cells and how we can exploit this knowledge to enhance the benefits offered by benign microbes, limit the damage caused by malign ones and begin the process of synthesizing artificial ones to meet needs in human society"--Provided by publisher. 606 $aBacterial genomes 615 0$aBacterial genomes. 676 $a572.86293 700 $aDorman$b Charles J.$01217826 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910555146403321 996 $aStructure and function of the bacterial genome$92816266 997 $aUNINA