LEADER 07087nam 2200505 450 001 9910555020003321 005 20220427162132.0 010 $a3-527-81099-4 010 $a3-527-81101-X 010 $a3-527-81098-6 035 $a(CKB)4100000011810976 035 $a(MiAaPQ)EBC6524946 035 $a(Au-PeEL)EBL6524946 035 $a(OCoLC)1244630198 035 $a(EXLCZ)994100000011810976 100 $a20211014d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiological soft matter $efundamentals, properties, and applications /$fedited by Corinne Nardin and Helmut Schlaad 210 1$aHoboken, New Jersey :$cJohn Wiley & Sons, Incorporated,$d[2021] 210 4$d©2021 215 $a1 online resource (291 pages) $cillustrations 300 $aIncludes index. 311 $a3-527-34348-2 327 $aCover -- Title Page -- Copyright -- Contents -- Preface -- Part I Natural and Artificial Polymers -- Chapter 1 DNA Nanoengineering and DNA?Driven Nanoparticle Assembly -- 1.1 Introduction -- 1.2 From the DNA Molecule to Nanotechnologies -- 1.3 DNA Nanostructures: From Holliday Junctions to 3D Origami -- 1.4 DNA?Directed Assembly of Particles: From Concepts to the Realization of Ordered Assemblies -- 1.4.1 DNA/Nanoparticle Assembly: Primary Functionalization Strategies -- 1.4.2 Toward High?Order Crystalline Structures -- 1.4.3 Crystallization of Heterogeneous Systems -- 1.4.4 DNA/Nanoparticle Assembly: Applications -- 1.5 Nanoengineering of DNA Self?Assembled Al/CuO Nanothermite -- 1.5.1 Fundaments and Characterization of DNA/Surface Chemistry and Grafting Strategies -- 1.5.1.1 DNA/Alumina Interaction Evaluation Through Infrared Spectroscopy and First Principles Calculations -- 1.5.1.2 Functionalization Protocol and Colloidal Characterization -- 1.5.1.3 Quantification of Streptavidin and DNA Surface Densities -- 1.5.2 Kinetics of DNA?Directed Assembly of Al and CuO Nanoparticles -- 1.5.2.1 Design and Impact of the DNA Coding Sequence -- 1.5.3 Structural and Energetic Properties of the Al/CuO Bionanocomposite -- 1.6 Conclusion -- References -- Chapter 2 Polysaccharides and Glycoproteins -- 2.1 Introdution -- 2.2 Polysaccharides from Plants -- 2.3 Polysaccharides from Microorganisms -- 2.4 Polysaccharides from Marine Organisms -- 2.5 Glycoproteins from Animal Sources - Mammals -- 2.6 Summary -- References -- Chapter 3 Engineered Biopolymers -- 3.1 Polyhydroxyalkanoates -- 3.1.1 Medium?Chain?Length Polyhydroxyalkanoates -- 3.1.2 Poly(3?hydroxybutyrate) -- 3.1.3 Poly(4?hydroxybutyrate) -- 3.1.4 Poly(3?hydroxyvalerate) -- 3.1.5 Poly(3?hydroxybutyrate?co?3?hydroxyvalerate) -- 3.2 Poly(lactic acid) (PLA) -- 3.2.1 Poly(l?lactic acid). 327 $a3.2.2 Poly(d?lactic acid) -- 3.2.3 Poly(dl?lactic acid) -- 3.3 Genetically Modified Polymers -- 3.3.1 Genetically Modified Amino Acid?Based Polymers -- 3.3.1.1 Elastin?Like Recombinamers (ELRs) -- 3.3.1.2 Inorganic?Binding Peptides -- 3.3.2 Genetically Modified Saccharide?Based Polymers -- 3.3.2.1 Bacterial Cellulose -- 3.4 Conclusion -- References -- Chapter 4 Engineered Hydrogels -- 4.1 Properties of Hydrogels -- 4.1.1 Modification and Functionalization -- 4.1.1.1 Methacrylation -- 4.1.1.2 PEGylation -- 4.1.1.3 PNIPAm Conjugated Hydrogels -- 4.1.1.4 Hydrogels of Recombinant Polymers -- 4.1.2 New Approaches for 3D Hydrogel Preparation -- 4.1.2.1 Cryogels -- 4.1.2.2 Bottom?Up 3D Hydrogel Preparation Methods -- 4.2 Conclusion -- References -- Part II Macromolecular Assemblies -- Chapter 5 Lipid Membranes: Fusion, Instabilities, and Cubic Structure Formation -- 5.1 Introduction to Lipid Self?assembly and Membrane Organization -- 5.2 Lipid Membrane Instabilities and Phase Transitions -- 5.3 Shape Deformations and Membrane Curvature -- 5.4 Membrane Fusion -- 5.5 Cubic Membranes In Vivo and Bio?inspired Materials with Cubic Membrane Topology -- 5.6 Conclusion and Outlook -- Acknowledgments -- References -- Chapter 6 Small Molecule Inhibitors for Amyloid Aggregation -- 6.1 Introduction -- 6.2 Targeting Strategies for Inhibition of Amyloid Aggregation -- 6.3 Classes of Inhibitors -- 6.3.1 Peptide?Based Amyloid Inhibitors -- 6.3.1.1 Peptides Derived from the Native Protein Sequence -- 6.3.1.2 Metal Ion Scavenging Peptides -- 6.3.1.3 ??Sheet Breaker Peptides -- 6.3.1.4 Peptides Containing d?Amino Acids -- 6.3.1.5 Molecules Targeting ??Helical State of Amyloid Proteins -- 6.3.1.6 Peptidomimetics -- 6.3.1.7 Cyclic Peptide Amyloid Inhibitors (CPAIs) -- 6.3.2 Non?peptide?Based Small Molecules -- 6.3.2.1 Quinones/Polyphenols/Natural Compounds. 327 $a6.3.2.2 Macrocyclic Inhibitors -- 6.4 Future Outlook -- Acknowledgments -- References -- Chapter 7 Inorganic Nanomaterials as Promoters/Inhibitors of Amyloid Fibril Formation -- 7.1 Introduction -- 7.2 Nanodiamonds -- 7.3 Carbon Nanotubes -- 7.3.1 Multiwalled Carbon Nanotubes -- 7.3.2 Single?Walled Carbon Nanotubes -- 7.4 Fullerenes-C60 -- 7.5 Graphene/Graphene Oxide -- 7.6 Quantum Dots -- 7.7 Semiconductor Quantum Dots -- 7.8 Carbon/Graphene Quantum Dots -- 7.9 Iron Nanoparticles -- 7.10 Titanium Dioxide Nanoparticles -- 7.11 Gold Nanoparticles -- 7.12 Other Nanoparticles Based on Metals/Metalloids -- 7.13 Conclusion -- Acknowledgment -- References -- Part III Mechanobiology -- Chapter 8 Mechanobiology -- 8.1 Extracellular Matrix (ECM) -- 8.1.1 ECM Structure and Composition -- 8.1.1.1 Proteins of ECM -- 8.1.1.2 Glycosaminoglycans -- 8.1.1.3 Growth Factors -- 8.1.2 ECM Functions -- 8.1.3 ECM Properties -- 8.1.3.1 Physical Properties -- 8.1.3.2 Chemical Properties -- 8.1.3.3 Mechanical Properties -- 8.2 Cell Adhesion -- 8.2.1 Molecules in Cell Adhesion -- 8.2.2 Cell?to?Cell Interactions -- 8.2.2.1 Cell Junctions -- 8.2.2.2 Cell Polarity -- 8.2.3 Signaling Pathways in Cell Adhesion -- 8.2.3.1 Principles of Cell Adhesion Signaling -- 8.2.3.2 Tissue?Specific Cell Adhesion Molecules -- 8.2.3.3 Cell Migration Guidance -- 8.3 Cell?to?ECM Interactions -- 8.4 Interactions with Substrate and Tissue Engineering -- 8.4.1 Properties of Substrates -- 8.4.1.1 Physical Properties -- 8.4.1.2 Chemical Properties -- 8.4.1.3 Mechanical Properties -- 8.5 Mechanobiology, Mechanotransduction, and Force Transmission -- 8.5.1 Concepts -- 8.5.1.1 Mechanobiology -- 8.5.1.2 Force Transduction -- 8.5.1.3 Mechanotransduction -- 8.5.2 Cell Surface Receptors as Mechanosensors -- 8.5.3 Focal Adhesion Kinase Signaling -- 8.5.4 Cytoskeleton as a Force?Transducing Element. 327 $a8.6 Conclusion -- References -- Index -- EULA. 606 $aBiomolecules 606 $aBiochemistry 615 0$aBiomolecules. 615 0$aBiochemistry. 676 $a572 702 $aSchlaad$b Helmut 702 $aNardin$b Corinne 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910555020003321 996 $aBiological soft matter$92820945 997 $aUNINA