LEADER 01170nam 2200397 450 001 9910554863903321 005 20200825034805.0 010 $a1-948306-96-4 010 $a1-119-72340-X 010 $a1-119-72344-2 035 $a(CKB)4100000010871058 035 $a(MiAaPQ)EBC6207715 035 $a(EXLCZ)994100000010871058 100 $a20200825d2020 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSOC for supply chain$hMarch 1, 2020 $eguide : reporting on an examination of controls relevant to security, availability, processing integrity, confidentiality, or privacy /$fAICPA 210 1$aDurham, North Carolina :$cWiley,$d[2020] 210 4$dİ2020 215 $a1 online resource (368 pages) 300 $aIncludes index. 311 $a1-948306-95-6 606 $aLogistics 608 $aElectronic books. 615 0$aLogistics. 676 $a355.411 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910554863903321 996 $aSOC for supply chain$92817229 997 $aUNINA LEADER 04937nam 22006255 450 001 9910160261203321 005 20251116171108.0 010 $a3-319-49674-3 024 7 $a10.1007/978-3-319-49674-0 035 $a(CKB)3710000001022378 035 $a(DE-He213)978-3-319-49674-0 035 $a(MiAaPQ)EBC4789406 035 $a(PPN)198340672 035 $a(iGPub)SPNA0049255 035 $a(EXLCZ)993710000001022378 100 $a20170118d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFibrous Proteins: Structures and Mechanisms /$fedited by David A.D. Parry, John M. Squire 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (VIII, 629 p. 154 illus., 123 illus. in color.) 225 1 $aSubcellular Biochemistry,$x0306-0225 ;$v82 311 08$a3-319-49672-7 320 $aIncludes bibliographical references at the end of each chapters. 327 $aFibrous Protein Structures: Hierarchy, History and Heroes -- Coiled-coil design: updated and upgraded -- Functional and Structural Roles of Coiled Coils -- The Structure and Topology of ?-Helical Coiled Coils -- Structural Transition of Trichocyte Keratin Intermediate Filaments During Development in the Hair Follicle -- Crystallographic studies of intermediate filament proteins -- Lessons from animal models of cytoplasmic intermediate filament proteins -- Filamentous Structure of Hard ?-Keratins in the Epidermal Appendages of Birds and Reptiles -- Tropomyosin Structure, Function, and Interactions: A Dynamic Regulator -- Titin and Nebulin in Thick and Thin Filament Length Regulation -- Myosin and Actin Filaments in Muscle: Structures and Interactions -- Dystrophin and spectrin, two highly dissimilar sisters of the same family -- Fibrin Formation, Structure and Properties -- Fibrillar collagens -- Recombinant structural proteins and their use in future materials -- Properties of engineered and fabricated silks -- Biomaterials Made from Coiled Coil Peptides -- Bioengineered Collagens. . 330 $aThis book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease. The importance of the ?-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all ?-fibrous proteins (and parts of some globular proteins) is underlined by three Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily. Also described are fibrous proteins based on the ?-pleated sheet and collagen conformations. Recombinant structural proteins, especially of silk and collagen, are discussed in the context of developing new biomaterials with varied applications. Established researchers and postgraduate students in the fields of protein chemistry, biochemistry and structural biophysics will find Fibrous Proteins: Structures and Mechanisms to be an invaluable collection of topical reviews that describe the basic advances made in the field of fibrous proteins over the past decade. This book, written by recognized authorities in the field, provides a clear account of the current status of fibrous protein research and, in addition, establishes the basis for deciding the most appropriate directions for future activity, including the applications of protein engineering and the commercial exploitation of new biomaterials. 410 0$aSubcellular Biochemistry,$x0306-0225 ;$v82 606 $aProteins 606 $aGene expression 606 $aBiophysics 606 $aBiophysics 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 615 0$aProteins. 615 0$aGene expression. 615 0$aBiophysics. 615 0$aBiophysics. 615 14$aProtein Science. 615 24$aGene Expression. 615 24$aBiological and Medical Physics, Biophysics. 676 $a547.75 702 $aParry$b David A.D$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSquire$b John M$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910160261203321 996 $aFibrous Proteins: Structures and Mechanisms$92233494 997 $aUNINA