LEADER 05129nam 2200637 450 001 9910136280003321 005 20230621141326.0 010 $a9782889195732 (ebook) 035 $a(CKB)3710000000586914 035 $a(SSID)ssj0001695645 035 $a(PQKBManifestationID)16545944 035 $a(PQKBTitleCode)TC0001695645 035 $a(PQKBWorkID)15066269 035 $a(PQKB)25091253 035 $a(WaSeSS)IndRDA00058406 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48402 035 $a(EXLCZ)993710000000586914 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGenetics and epigenetics of fetal alcohol spectrum disorders /$fedited by: Feng C. Zhou and Stephen Mason 210 $cFrontiers Media SA$d2015 210 31$aSwitzerland :$cFrontiers Media SA,$d2015 215 $a1 online resource (114 pages) $cillustrations 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 320 $aIncludes bibliographical references. 330 $aWomen drinking during pregnancy can result in Fetal Alcohol Spectrum Disorder (FASD), which features neurodevelopmental deficit, facial dysmorphology, growth retardation, and learning disability. Research suggests the human brain is precisely shaped through an intrinsic, genetic-cellular expression that is orchestrated further upstream by an epigenetic program. This program can be influenced by environmental inputs such as alcohol. Current research suggests the genetic and epigenetics of FASD are becoming intertwined and inseparable. Now is the time for investigators to combine genetic, genomic and epigenetic alcohol research into an accessible, online platform discussion. Genetic analyses inform gene sets vulnerable to alcohol exposure during early neurulation. Prenatal alcohol exposure alters expression of gene subsets, including genes involved in neural specification, hematopoiesis, methylation, chromatin remodeling, histone variants, eye and heart development. Recently, quantitative map locusing (QTLs) that mediate alcohol-induced phenotype were identified between two mouse strains. Another question is -- besides amount, dose, and stage of alcohol exposure, why only 5% of women drinking have a newborn with FAS? Studies are also ongoing to answer this question by characterizing genome-wide expression, allele-specific expression (ASE), gene polymorphisms (SNPs) and maternal genetic factors that influence alcohol vulnerability. Alcohol exposure during pregnancy, which can lead to FASD, has been used as a model to resolve the epigenetic pathway between environment and phenotype. Epigenetics modifies genetic outputs through alteration of 3D chromatin structure and accessibility of transcriptional machinery. Several laboratories have reported altered epigenetics, including DNA methylation and histone modification, in multiple models of FASD. During development DNA methylation is dynamic, yet orchestrated as methylation progresses in a precise spatiotemporal manner during neurulation and coincides with neural differentiation. Alcohol can directly influence epigenetics through alterations of the methionine pathway and subsequent DNA or histone methylation/acetylation. Alcohol also alters noncoding RNA including miRNA and transposable elements (TEs). Evidence suggests that miRNA expression may mediate ethanol teratology, and TEs may be affected by alcohol through altering DNA methylation at LTR. In this manner epigenetic and genetics of FASD are becoming mechanistically intertwined. Can alcohol-induced epigenomic alterations be passed through generations? Early epidemiological studies revealed infants with FASD-like features in the absence of maternal alcohol, where the fathers were alcoholics. Novel mechanisms for alcohol-induced phenotypes include altered sperm DNA methylation, hypomethylated paternal allele and heritable epimutation. These studies predict heritability of alcohol-induced epigenetic abnormalities and gene functionality across generations. 606 $aPregnant women$xAlcohol use 606 $aFetal alcohol spectrum disorders$xEvaluation 606 $aChildren of prenatal alcohol abuse 610 $aDNA Methylation 610 $aFetal Alcohol Syndrome 610 $ahistone modification 610 $aEpigenetic medicine 610 $aGenomics 610 $aAlcoholism 610 $atransgenerational 610 $aPregnancy drinking 610 $aFASD 610 $aGene environmental interaction 615 0$aPregnant women$xAlcohol use. 615 0$aFetal alcohol spectrum disorders$xEvaluation. 615 0$aChildren of prenatal alcohol abuse. 700 $aFeng C Zhou$4auth$01365325 702 $aZhou$b Feng C 702 $aMason$b Stephen 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910136280003321 996 $aGenetics and epigenetics of fetal alcohol spectrum disorders$93387029 997 $aUNINA LEADER 07032nam 22008295 450 001 9910554496003321 005 20231110212258.0 010 $a3-11-069730-0 024 7 $a10.1515/9783110697308 035 $a(CKB)4100000011726276 035 $a(DE-B1597)546544 035 $a(DE-B1597)9783110697308 035 $a(OCoLC)1233040820 035 $a(MiAaPQ)EBC6458280 035 $a(Au-PeEL)EBL6458280 035 $a(OCoLC)1232277482 035 $a(EXLCZ)994100000011726276 100 $a20210125h20212021 fg 101 0 $ager 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aKritische Fallstudien zum Verhalten in Organisationen /$fIrma Rybnikova, Anna Fornfeist 210 1$aMünchen ;$aWien : $cDe Gruyter Oldenbourg, $d[2021] 210 4$d©2021 215 $a1 online resource (XI, 199 p.) 225 0 $aDe Gruyter Studium 311 $a3-11-069729-7 327 $tFrontmatter -- $tInhaltsübersicht -- $t1 Verhalten in Organisationen und kritische Fallstudien: eine Einleitung -- $tThemengebiet I: Arbeits- und Aufgabengestaltung -- $t2 Bore-out: Monotonie am Arbeitsplatz und ihre Folgen -- $t3 Wie ein ?Luxusproblem? zur Arbeitsüberforderung führen kann -- $t4 Arbeitsdruck durch Personalmangel -- $t5 Schlechte Arbeitsbedingungen in der Ausbildung -- $t6 Vertrauensarbeitszeit -- $t7 Familienmitglieder als Personal -- $tThemengebiet II: Ungerechtigkeit und Benachteiligung am Arbeitsplatz -- $t8 ?Ohne Moos nichts los? -- $t9 Arbeitsunzufriedenheit nach einer Dienstreise -- $t10 Zwischen zwei Versetzungen -- $t11 Ein 800.000? teures Missverständnis -- $t12 Benachteiligung von ausländischen Arbeitskräften -- $t13 Diskrepanz zwischen Festangestellten und Aushilfen -- $t14 Zwei-Klassen-Gesellschaft -- $t15 Benachteiligung von Frauen am Arbeitsplatz -- $tThemengebiet III: Sexuelle Belästigung -- $t16 ?Ein kühles Blondes? -- $t17 Sexuelle Belästigung am Arbeitsplatz -- $t18 Wieso führt ein Zuzwinkern zur Abmahnung? -- $tThemengebiet IV: Destruktive Führung -- $t19 Destruktive Geschäftsführung -- $t20 Der Chef als Vorbild ? eine Fallstudie und Analyse über Narzissmus und destruktive Führung -- $tThemengebiet V: Unfälle in Organisationen -- $t21 Das Zugunglück von Eschede -- $t22 Germanwings-Flug 4U9525 am 24.03.2015 -- $t23 Die Flugzeugkollision von Überlingen -- $t24 Die Katastrophe der Loveparade 2010 in Duisburg -- $tStichwortverzeichnis 330 $aFallstudien, die zu den bewährtesten Lehr- und Lernmethoden im Personalmanagement gehören, sind im deutschsprachigen Raum immer noch selten oder nur vereinzelt zu finden. Dieses Buch bietet eine Reihe von Fallstudien im Bereich organisationales Verhalten und Personalmanagement. Die Fallstudien verbindet ihr kritischer Ansatz, der sich in ausgewählten Themen niederschlägt, wie z.B.: - destruktive Führung - Unfälle in Organisationen - Fehlbeanspruchung von Mitarbeiter*innen - Diskriminierung und Ungerechtigkeit am Arbeitsplatz - Mobbing und sexuelle Belästigung am Arbeitsplatz. Das Besondere der hier aufgeführten Fallstudien besteht darin, dass sie von BWL-Studierenden der Hochschule Hamm-Lippstadt im Rahmen von Seminaren zu dem Themengebiet Personalmanagement erarbeitet worden sind. In die Fallstudien sind teilweise die eigenen Arbeitserfahrungen der Autor*innen eingeflossen, zum Teil waren es beobachtete Erfahrungen oder auch öffentliche Berichterstattungen, die zu den Fallstudien inspirierten. Die behandelten Probleme werden in den Fallstudien knapp, pointiert und verständlich umrissen sowie eine Analyse des Geschehens aus einer theoretischen Sicht angeboten. Mit Hilfe der hier vorgestellten Fallstudien können die Lehrenden ihre Veranstaltungen praxisnah und interaktiv gestalten sowie die Fallstudien als Prüfungsmethode anwenden. Die Studierenden hingegen gewinnen einen Einblick in die Realität des Arbeitslebens und können damit ihre Handlungskompetenzen erheblich erweitern. Durch die theoretische Analyse, die jeder Fallstudie folgt, wird zudem verdeutlicht, wie ein Praxis-Theorie-Bezug hergestellt werden kann und wann bzw. ob er neue Erkenntnisse fördert. 410 3$aDe Gruyter Studium 606 $aBUSINESS & ECONOMICS / Organizational Behavior$2bisacsh 610 $aHR management. 610 $aWorkplace conduct. 610 $acase studies. 610 $aorganizations. 610 $apersonnel management. 615 7$aBUSINESS & ECONOMICS / Organizational Behavior. 702 $aAbdülhamit Han$b Aksüt, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aAlisha$b Düsing, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aAndrea$b Kallenbach, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aAnna$b Fornfeist, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aCaroline$b Bittner, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aDeniz$b Akyaman, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aFornfeist$b Anna, $4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aIrma$b Rybnikova, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aIsabelle$b Wild, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aJasper$b Konertz, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aJoelle-Madeline$b Cihlar, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aJohanna$b Wittmann, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aLaida$b Uspik, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aLisa$b Rietze, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aMarlene$b Bayer, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aMats$b Schulte, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aMatti$b Mennebröcker, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aMelina$b Mantikowski, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aNiclas$b Olschenka, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aOlga$b Miller, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aOliver$b Lamm, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aRico$b Brandl, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aRybnikova$b Irma , $4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aStefanie$b Moser, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aSvetlana$b Hofmann, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aVanessa$b Aberle, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aVeronika$b Klassen, $4ctb$4https://id.loc.gov/vocabulary/relators/ctb 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a9910554496003321 996 $aKritische Fallstudien zum Verhalten in Organisationen$92817446 997 $aUNINA LEADER 04405nam 2200637Ia 450 001 9910782497403321 005 20230421044312.0 010 $a1-281-81448-2 010 $a9786611814489 010 $a0-8264-4130-0 035 $a(CKB)1000000000554733 035 $a(EBL)436611 035 $a(OCoLC)437129442 035 $a(SSID)ssj0000092669 035 $a(PQKBManifestationID)11130665 035 $a(PQKBTitleCode)TC0000092669 035 $a(PQKBWorkID)10023091 035 $a(PQKB)10570100 035 $a(MiAaPQ)EBC436611 035 $a(Au-PeEL)EBL436611 035 $a(CaPaEBR)ebr10250724 035 $a(CaONFJC)MIL181448 035 $a(OCoLC)893334302 035 $a(EXLCZ)991000000000554733 100 $a19980224d1997 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$a1 and 2 Chronicles$hVolume 1$i1 Chronicles 1-2 Chronicles 9 : Israel's place among the nations$b[electronic resource] /$fWilliam Johnstone 210 $aSheffield $cSheffield Academic Press$dc1997 215 $a1 online resource (418 p.) 225 1 $aJournal for the study of the Old Testament. Supplement series ;$v253 300 $aDescription based upon print version of record. 311 $a1-85075-693-7 320 $aIncludes bibliographical references and indexes. 327 $aContents; Abbreviations; Introduction; 1 Chronicles 1: Israel's Place within the Human Family; 1 Chronicles 2.1-2: Preview of 1 Chronicles 2-8; 1 Chronicles 2.3-4.23: Judah and the House of David; 1 Chronicles 4.24-5.2: Simeon; 1 Chronicles 5.3-26: The East Bank Tribes: Reuben, Gad and Half-Manasseh; 1 Chronicles 6: Levi; 1 Chronicles 7-9: The West Bank Tribes and Jerusalem; 1 Chronicles 7.1-5: Issachar; 1 Chronicles 7.6-13: Benjamin (1) with Naphtali; 1 Chronicles 7.14-19: Manasseh; 1 Chronicles 7.20-29: Ephraim; 1 Chronicles 7.30-40: Asher; 1 Chronicles 8: Benjamin (2) 327 $a1 Chronicles 9.1-34: The Population of Jerusalem1 Chronicles 9.35-10.14: The Reign of Saul; 1 Chronicles 11.1-29.30: David: Enabler of Israel's Destiny among the Nations of the World?; 1 Chronicles 11.1-9: David, king of 'All Israel'; Jerusalem, City of David; 1 Chronicles 11.10-12.40: The Roll of Warriors who Joined Forces with King David; 1 Chronicles 13: David's Initiative to Fetch the Ark of God is Cut Short; 1 Chronicles 14.1-16.43: The Installation of the Ark in Jerusalem; 1 Chronicles 17: David's Proposal to Build a Temple is Rejected 327 $a1 Chronicles 18-20: The Fulfilment of the LORD's Promise to Subdue David's Enemies1 Chronicles 21.1-22.4: The Census: Pivotal Event of David's Reign; 1 Chronicles 22.5-19: David Commissions Solomon to Build the Temple; 1 Chronicles 23-27: The Personnel of Temple and Community; 1 Chronicles 28-29: David's Reign Fulfilled; 2 Chronicles 1-9: The Reign of Solomon; 2 Chronicles 1.1-13: The Sacral Assembly Is Convened at the Tabernacle at Gibeon. The Theological Basis of Solomon's Rule; 2 Chronicles 2.3-16: Solomon's Correspondence with Huram of Tyre 327 $a2 Chronicles 2.17-5.1: Solomon Builds the Temple2 Chronicles 5.2-7.22: The Dedication of the Temple; 2 Chronicles 8.1-9.31: The Universal Recognition of Solomon's Reign; Bibliography; Index of References; Index of Selected Key Terms 330 $aThis two-part commentary argues that Chronicles, placed as it is among the 'historical books' in the traditional Old Testament of the Christian church, is much misunderstood. Restored to its proper position as the final book in the canon as arranged in the order of the Hebrew Bible, it is rather to be understood as a work of theology essentially directed towards the future. The Chronicler begins his work with the problem facing the whole human race in Adam-the forfeiture of the ideal of perfect oneness with God's purpose. 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