LEADER 04363nam 22005655 450 001 9910552741203321 005 20240429111625.0 010 $a9783030916237$b(electronic bk.) 010 $z9783030916213 024 7 $a10.1007/978-3-030-91623-7 035 $a(MiAaPQ)EBC6926774 035 $a(Au-PeEL)EBL6926774 035 $a(CKB)21403602000041 035 $a(DE-He213)978-3-030-91623-7 035 $a(PPN)261518607 035 $a(EXLCZ)9921403602000041 100 $a20220314d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPhosphate Metabolism $eFrom Physiology to Toxicity /$fedited by Mohammed S. Razzaque 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (167 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1362 311 08$aPrint version: Razzaque, Mohammed S. Phosphate Metabolism Cham : Springer International Publishing AG,c2022 9783030916213 320 $aIncludes bibliographical references and index. 327 $aPreface -- Chapter 1. Phosphate Metabolism: from Physiology to Toxicity (Mohammed S. Razzaque) -- Chapter 2. Phosphate Burden and Inflammation (Sarah Erem , Satoko Osuka and Mohammed S. Razzaque) -- Chapter 3. Extracellular Phosphate, Inflammation and Cytotoxicity (Toshimi Michigami, Miwa Yamazaki, Mohammed S. Razzaque) -- Chapter 4. Phosphate-sensing (Yuichi Takashi and Seiji Fukumoto) -- Chapter 5. Vitamin D and phosphate interactions in health and disease (Nuraly S. Akimbekov, Ilya Digel, Dinara K. Sherelkhan, Mohammed S. Razzaque) -- Chapter 6. Fibroblast growth factor 23 as regulator of vitamin D metabolism (Shinya Nakatani; Ayumi Nakatani, Katsuhito Mori, Masanori Emoto; Masaaki Inaba; and Mohammed S. Razzaque) -- Chapter 7. Phosphate and Cellular Senescence (Ming Chang Hu and Orson W. Moe) -- Chapter 8. Phosphate toxicity and epithelial to mesenchymal transition (EMT) (Eric Lewis, Faith Seltun, Mohammed S. Razzaque, Ping He) -- Chapter 9. Phosphate & endothelial function: How sensing of elevated inorganic phosphate concentration generates signals in endothelial cells (Nima Abbasian, Alan Bevington and Dylan Burger) -- Chapter 10. Common dietary sources of natural and artificial phosphate in food (Ken-ichi Miyamoto, Joanna Oh, Mohammed S. Razzaque) -- Chapter 11. Phosphate is a Cardiovascular Toxin (Maren Leifheit-Nestler, Isabel Vogt, Dieter Haffner and Beatrice Richter) -- Chapter 12. Coordination of Phosphate and Magnesium Metabolism in Bacteria (Roberto E. Bruna, Christopher G. Kendra and Mauricio H. Pontes) -- Index. 330 $aThis contributed volume discusses the most important physiological aspects of phosphate metabolism, and how its pathological dysregulation can induce organ damage, which includes but is not limited to blood vessels, kidney, bone and tumor. The editor has selected a varied group of world renowned experts to provide a basic understanding of normal phosphate regulation, to then move on to explain the complex molecular mechanisms of abnormal phosphate regulation, also shedding some light on the downstream clinical consequences owing to phosphate toxicity. Each chapter clearly presents the biochemically important problems related to phosphate dysregulation with the necessary illustrations. Readers will be able to use the proposed book as a quick reference for updated information on phosphate metabolism, ranging from cellular system to physiology, from pathology to toxicity, also including the associated clinical consequences, without much prior acquaintance with the field. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1362 606 $aHuman physiology 606 $aHuman Physiology 606 $aFosfats$2thub 606 $aMetabolisme$2thub 608 $aLlibres electrònics$2thub 615 0$aHuman physiology. 615 14$aHuman Physiology. 615 7$aFosfats 615 7$aMetabolisme 676 $a572.5 676 $a612.3926 702 $aRazzaque$b Mohammed S. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910552741203321 996 $aPhosphate Metabolism$92803990 997 $aUNINA