LEADER 04860nam 2200433 450 001 9910551833403321 005 20221008090228.0 010 $a9783030854874$b(electronic bk.) 010 $z9783030854867 035 $a(MiAaPQ)EBC6899794 035 $a(Au-PeEL)EBL6899794 035 $a(OCoLC)1302009462 035 $a(CKB)21348188100041 035 $a(PPN)26152352X 035 $a(EXLCZ)9921348188100041 100 $a20221008d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aViruses $eintimate invaders /$fVan G. Wilson 210 1$aCham, Switzerland :$cSpringer,$d[2022] 210 4$d©2022 215 $a1 online resource (359 pages) 300 $aIncludes index. 311 08$aPrint version: Wilson, Van G. Viruses: Intimate Invaders Cham : Springer International Publishing AG,c2022 9783030854867 327 $aIntro -- Preface -- Acknowledgment -- Contents -- List of Figures -- 1: The Question of Life -- Weird Facts and Big Numbers -- From Ignorance to Fascination -- A Biological Primer - Multicellular Organisms -- Smaller, But Still Alive - Unicellular Organisms -- Biochemistry - You Can't Escape It -- Viruses At Last -- Additional Reading -- 2: Families, Forms, and Functions -- Taxonomy and Other Geeky Things -- Virions, the Viral Vehicle -- Alive or Not, Viruses Have a Life Cycle -- Infection and Disease-How Viruses Spread and Do Nasty Things -- Additional Reading -- 3: Ancient or New - On the Origin of Viruses -- We Don't Know Exactly Where We Came From, But We're Here Anyway -- Are Viruses the Chicken or the Egg? -- Hypotheses, Hypotheses, and More Hypotheses -- New Data at Last -- Closer to Home -- Papillomaviruses and Hominid Evolution -- Additional Reading -- 4: Of Predators and Prey -- Viral Infections - The Good, the Bad, and the Ugly -- Influenza - More Than Just Bad Air -- Hepatitis C - The Great Deceiver -- Herpes Varicella-Zoster Virus - Now You See It, Now You Don't -- Polyomaviruses and Anelloviruses - Predators or Passengers? -- Additional Reading -- 5: Immunity, Immunity, Immunity -- The Big Three -- Intrinsic Immunity - Always There When We Need It -- Innate Immunity - Locked and Loaded -- Adaptive Immunity - The Gift That Keeps on Giving -- Additional Reading -- 6: Viruses That Shaped Our World -- Smallpox - Mankind's First Viral Conquest -- Polio - A Force for Change -- HIV/AIDS - A New Pandemic for the Twentieth Century and Beyond -- Additional Reading -- 7: SV40 - An Obscure Monkey Virus and the Golden Age of Molecular Biology -- Viruses, Viruses, and More Viruses -- Polio Vaccines and A Stealth Simian Virus -- To Be or Not To Be - Is SV40 a Human Tumor Virus? -- The SV40 Revolution -- p53 - The Guardian of the Genome. 327 $aAsilomar and the Birth of Biosafety -- Additional Reading -- 8: Viral Cancer -- The Infectious Beginnings of Cancer Research -- The Oncogene Revelation -- Human Retroviruses at Last -- Herpesviruses Turn Oncogenic -- Hepatitis Viruses and Hepatocellular Carcinoma -- Human Papillomaviruses - Cancer as an STD -- Merkel Polyomavirus - Finally an Oncogenic Human Polyomavirus -- The Seven Deadly Cancer Viruses -- Additional Reading -- 9: The Viruses Within - How Human Are We? -- Adam and EVEs -- HERVs, HERVs, and More HERVs -- Beyond HERVs -- Assailants or Allies? -- The HERVs That Made Us Human -- The Dark Side -- Additional Reading -- 10: Vaccines and the Conquest of Viruses -- The Era of Vaccines -- Vaccinology 101 -- The Road Is Long with Many a Winding Turn -- Anti-Vaxxers: The Force Awakens -- Vaccine Technology - A Glimpse of the Future -- Additional Reading -- 11: New and Emerging Viruses -- One Planet, Many Viruses, Countless Opportunities for Infections -- The Unique Role of Bats -- The Virus-Host Interface -- Once and Future Threats: Influenza and Coronaviruses -- Additional Reading -- 12: Beyond Antibiotics - Are Phages Our Allies? -- From Fact to Fiction -- A Brief History of Phage Therapy -- A Phage Primer -- The Antibiotic Problem -- Phage Therapy Redux -- A Glimpse of the Future -- Additional Reading -- 13: Viruses in Gene Therapy and Cancer Therapeutics -- Gene Therapy Emerges -- From Adversary to Deliveryman - Harnessing Retroviruses for Gene Therapy -- Into The Fray - What Other Viruses Bring to Gene Therapy -- Oncolytic Viruses - Pitting One Killer Against Another -- Additional Reading -- Epilogue -- Index. 606 $aViruses 615 0$aViruses. 676 $a579.2 700 $aWilson$b Van Gene$01240848 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910551833403321 996 $aViruses$92878669 997 $aUNINA