LEADER 04539nam 22007455 450 001 9910547298303321 005 20240215144921.0 010 $a9783030798710$b(electronic bk.) 010 $z9783030798703 024 7 $a10.1007/978-3-030-79871-0 035 $a(MiAaPQ)EBC6893541 035 $a(Au-PeEL)EBL6893541 035 $a(CKB)21282054500041 035 $a(DE-He213)978-3-030-79871-0 035 $a(PPN)260826138 035 $a(EXLCZ)9921282054500041 100 $a20220220d2021 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCell Culture Engineering and Technology $eIn appreciation to Professor Mohamed Al-Rubeai /$fedited by Ralf Pörtner 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (552 pages) 225 1 $aCell Engineering,$x2542-9515 ;$v10 311 08$aPrint version: Pörtner, Ralf Cell Culture Engineering and Technology Cham : Springer International Publishing AG,c2022 9783030798703 327 $aBiopharmaceuticals Produced from Cultivated Mammalian Cells -- Remote Control of Mammalian Therapeutic Designer Cells -- Next generation cell engineering using microRNAs -- An Omic?s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production -- Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations -- Monoclonal antibody glycoengineering for biopharmaceutical quality assurance -- Next-generation cell engineering platform for improving recombinant protein production in mammalian cells -- Manufacturing human pluripotent stem cells and differentiated progenitors -- Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications -- Process Design for hMSC Products in Stirred Tank Bioreactors -- Bio-production of Adeno-associated virus for gene therapy -- Scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale -- Intensified and Continuous mAb Production with Single-Use Systems -- Mathematical modelling of cell culture processes -- Model-assisted design concepts for mammalian cell culture processes -- Bioprocess monitoring and control -- Industrial Monitoring of Cell Culture. 330 $aThis contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering. 410 0$aCell Engineering,$x2542-9515 ;$v10 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aCytology 606 $aBiology$xTechnique 606 $aRegenerative medicine 606 $aBiomedical engineering 606 $aBiomedical Research 606 $aCell Biology 606 $aBiological Techniques 606 $aRegenerative Medicine and Tissue Engineering 606 $aBiomedical Engineering and Bioengineering 606 $aEnginyeria de teixits$2thub 608 $aLlibres electrònics$2thub 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aCytology. 615 0$aBiology$xTechnique. 615 0$aRegenerative medicine. 615 0$aBiomedical engineering. 615 14$aBiomedical Research. 615 24$aCell Biology. 615 24$aBiological Techniques. 615 24$aRegenerative Medicine and Tissue Engineering. 615 24$aBiomedical Engineering and Bioengineering. 615 7$aEnginyeria de teixits 676 $a574.0724 676 $a571.638 700 $aPo?rtner$b Ralf$01207271 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910547298303321 996 $aCell Culture Engineering and Technology$92784788 997 $aUNINA