LEADER 04261oam 2200721I 450 001 9910540114303321 005 20240418013034.0 010 $a0-262-32986-7 010 $a0-262-32985-9 035 $a(CKB)3710000000465899 035 $a(EBL)3433803 035 $a(SSID)ssj0001542972 035 $a(PQKBManifestationID)16132156 035 $a(PQKBTitleCode)TC0001542972 035 $a(PQKBWorkID)14791867 035 $a(PQKB)10527999 035 $a(StDuBDS)EDZ0001530664 035 $a(OCoLC)919201534 035 $a(MdBmJHUP)muse47289 035 $a(OCoLC)919201534$z(OCoLC)960929265$z(OCoLC)1055368403$z(OCoLC)1066446165$z(OCoLC)1066668520$z(OCoLC)1076713843$z(OCoLC)1081250004 035 $a(OCoLC-P)919201534 035 $a(MaCbMITP)10460 035 $a(Au-PeEL)EBL3433803 035 $a(CaPaEBR)ebr11093305 035 $a(CaONFJC)MIL826829 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/78538 035 $a(MiAaPQ)EBC3433803 035 $a(EXLCZ)993710000000465899 100 $a20150826d2015 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTranslational neuroscience $etoward new therapies /$fedited by Karoly Nikolich and Steven E. Hyman ; Program Advisory Committee, Steven E. Hyman, Julia Lupp, Robert C. Malenka, Karoly Nikolich, Menelas N. Pangalos, and Bernd Sommer 205 $a1st ed. 210 1$aCambridge, MA :$cThe MIT Press,$d[2015] 215 $a1 online resource (319 p.) 225 1 $aStrungmann forum reports 300 $aDescription based upon print version of record. 311 $a0-262-02986-3 320 $aIncludes bibliographical references and index. 327 $aIntro; Contents; The Ernst Stru?ngmann Forum; List of Contributors; 1 - Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2 - What Do We Know about Early Onset Neurodevelopmental Disorders?; 3 - Psychotic Disorders and the Neurodevelopmental Continuum; 4 - Neurodevelopmental Disorders; 5 - Neurodegenerative Diseases; 6 - Preclinical and Clinical Understanding; 7 - Neurodegenerative Diseases 327 $a8 - How Might We Get from Genes to Circuits to Disease?9 - How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10 - Pathophysiological Toolkit; 11 - Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12 - From Rodent Behavioral Models to Human Disorders; 13 - Bridging the Gap between Patients and Models; 14 - The Revolution Has Begun 330 8 $aToday, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. 410 0$aStru?ngmann Forum reports. 606 $aNeurosciences$xResearch 606 $aNervous system$xDiseases 606 $aDrug development 610 $aNEUROSCIENCE/General 610 $aBIOMEDICAL SCIENCES/General 615 0$aNeurosciences$xResearch. 615 0$aNervous system$xDiseases. 615 0$aDrug development. 676 $a616.80072 701 $aNikolich$b Karoly$01337329 701 $aHyman$b Steven E$01275600 801 0$bOCoLC-P 801 1$bOCoLC-P 906 $aBOOK 912 $a9910540114303321 996 $aTranslational neuroscience$93391251 997 $aUNINA