LEADER 00958nam a22002771i 4500 001 991002408919707536 005 20040312131622.0 008 040407s2002 uik|||||||||||||||||eng 020 $a0415118360 035 $ab12918428-39ule_inst 035 $aARCHE-089803$9ExL 040 $aDip.to Filologia Class. e Scienze Filosofiche$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 082 04$a270.1 100 1 $aTrigg, Joseph Wilson$0486557 245 10$aOrigen /$cJoseph W. Trigg 250 $aRist. 260 $aLondon ;$aNew York :$bRoutledge,$c2002 300 $aXIII, 292 p. ;$c22 cm 440 4$aThe early church fathers 650 4$aOrigene 907 $a.b12918428$b02-04-14$c16-04-04 912 $a991002408919707536 945 $aLE007 270 TRI 01.01$g1$i2007000070109$lle007$o-$pE0.00$q-$rl$s- $t0$u1$v0$w1$x0$y.i13490345$z16-04-04 996 $aOrigen$9303630 997 $aUNISALENTO 998 $ale007$b16-04-04$cm$da $e-$feng$guik$h0$i1 LEADER 04837nam 22007095 450 001 9910523764103321 005 20251202145533.0 010 $a9783030849658$b(electronic bk.) 010 $z9783030849641 024 7 $a10.1007/978-3-030-84965-8 035 $a(MiAaPQ)EBC6823074 035 $a(Au-PeEL)EBL6823074 035 $a(CKB)20067296700041 035 $a(PPN)259387576 035 $a(BIP)82454652 035 $a(BIP)80928770 035 $a(DE-He213)978-3-030-84965-8 035 $a(EXLCZ)9920067296700041 100 $a20211202d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRedox Signaling and Biomarkers in Ageing /$fedited by Ufuk Çakatay 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (447 pages) 225 1 $aHealthy Ageing and Longevity,$x2199-9015 ;$v15 311 08$aPrint version: Çakatay, Ufuk Redox Signaling and Biomarkers in Ageing Cham : Springer International Publishing AG,c2022 9783030849641 320 $aIncludes bibliographical references and index. 327 $aRedox dynamic homeostasis and aging -- Intrinsic and extrinsic factors associated with redox homeostasis and biological aging -- Chapter 3: Disturbed redox homeostasis in the aging brain -- Impaired redox homeostasis in cardiovascular aging -- Redox homeostasis status influences skeletal muscle aging. 330 $aThis book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, ?-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike. . 410 0$aHealthy Ageing and Longevity,$x2199-9015 ;$v15 606 $aGeriatrics 606 $aBiochemical markers 606 $aAging 606 $aBiochemistry 606 $aOxidation-reduction reaction 606 $aGeriatrics 606 $aBiomarkers 606 $aAgeing 606 $aBiochemistry 606 $aRedox Biology 615 0$aGeriatrics. 615 0$aBiochemical markers. 615 0$aAging. 615 0$aBiochemistry. 615 0$aOxidation-reduction reaction. 615 14$aGeriatrics. 615 24$aBiomarkers. 615 24$aAgeing. 615 24$aBiochemistry. 615 24$aRedox Biology. 676 $a571.878 702 $aC?akatay$b Ufuk 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910523764103321 996 $aRedox Signaling and Biomarkers in Ageing$92594139 997 $aUNINA