LEADER 03121nam 2200577 450 001 9910827338303321 005 20230803214403.0 010 $a1-62637-381-7 024 7 $a10.1515/9781626373815 035 $a(CKB)3710000000892400 035 $a(Au-PeEL)EBL4451541 035 $a(CaPaEBR)ebr11271489 035 $a(OCoLC)960164156 035 $a(DE-B1597)623815 035 $a(DE-B1597)9781626373815 035 $a(MiAaPQ)EBC4451541 035 $a(EXLCZ)993710000000892400 100 $a20130905d2014 uy| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aMaking a life in multiethnic Miami $eimmigration and the rise of a global city /$fElizabeth M. Aranda, Sallie Hughes, Elena Sabogal 210 1$aBoulder, Colorado :$cLynne Rienner Publishers, Incorporated,$d2014. 215 $a1 online resource (383 pages) $cillustrations, maps 225 1 $aLatinos: exploring diversity and change 311 $a1-62637-041-9 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tContents -- $tList of Tables and Figures -- $tAcknowledgments -- $t1 Immigration in the Age of Global Insecurity -- $t2 The Contexts of Departure -- $t3 The Context of Reception -- $t4 Inequalities and Perceptions of Social Mobility -- $t5 Politics, Membership, and Representation -- $t6 Race, Discrimination, and Ethnic Rivalries -- $t7 Immigrant Emotions and Strategies of Co-Presence -- $t8 Translocal Placemaking and Belonging -- $t9 The Security of Home in a Global Era -- $tReferences -- $tIndex -- $tAbout the Book 330 $aWith more than a million immigrants from Latin America and the Caribbean, Miami, Florida, boasts the highest proportion of foreign-born residents of any US city. Charting the rise of Miami as a global city, Elizabeth Aranda, Sallie Hughes, and Elena Sabogal provide a panoramic study of the changing dynamics of the immigration experience. The authors move easily between an analysis of global currents and personal narratives, examining the many factors that shape the decision to emigrate and the challenges faced in making a new home. Offering a wealth of new insights, their work demonstrates why Miami is such an exceptional laboratory for studying the social forces and local effects of globalization on the ground.      410 0$aLatinos, exploring diversity and change. 606 $aImmigrants$zFlorida$zMiami 606 $aLatin Americans$zFlorida$zMiami 606 $aMulticulturalism$zFlorida$zMiami 607 $aMiami (Fla.)$xEthnic relations 607 $aMiami (Fla.)$xEmigration and immigration 615 0$aImmigrants 615 0$aLatin Americans 615 0$aMulticulturalism 676 $a975.9/381 700 $aAranda$b Elizabeth M.$f1973-$01666503 702 $aHughes$b Sallie 702 $aSabogal$b Elena 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910827338303321 996 $aMaking a life in multiethnic Miami$94025802 997 $aUNINA LEADER 10096nam 22006495 450 001 9910522957003321 005 20251113201016.0 010 $a3-030-91335-X 024 7 $a10.1007/978-3-030-91335-9 035 $a(MiAaPQ)EBC6838616 035 $a(Au-PeEL)EBL6838616 035 $a(CKB)20275119900041 035 $a(OCoLC)1292364254 035 $a(PPN)259386480 035 $a(DE-He213)978-3-030-91335-9 035 $a(EXLCZ)9920275119900041 100 $a20211220d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBehavioral Neurobiology of GABAB Receptor Function /$fedited by Styliani Vlachou, Kevin Wickman 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (331 pages) 225 1 $aCurrent Topics in Behavioral Neurosciences,$x1866-3389 ;$v52 311 08$aPrint version: Vlachou, Styliani Behavioral Neurobiology of GABAB Receptor Function Cham : Springer International Publishing AG,c2021 9783030913342 320 $aIncludes bibliographical references. 327 $aIntro -- Preface -- Contents -- A Brief History and the Significance of the GABAB Receptor -- 1 Introduction -- 2 GABAB Receptor Structure, Function, and Distribution -- 3 GABAB Receptor Ligands: Agonists, Antagonists, and Allosteric Modulators -- 4 GABAB Receptors as Potential Therapeutic Targets -- 4.1 Drug and Alcohol Use Disorders -- 4.2 Pain and Analgesia -- 4.3 Anxiety and Mood Disorders -- 4.4 Neurodegeneration -- 4.5 Cognitive Processes in Neurodevelopment, Health and Disease -- 4.6 Other Conditions Outside the CNS -- 5 Conclusion -- References -- Structural Basis of GABAB Receptor Regulation and Signaling -- 1 Heterodimers Are the Minimal Functional Receptor Units -- 2 Signal Transduction in the Receptor Heterodimer -- 3 Auxiliary KCTD Subunits -- 4 SD-Interacting Proteins -- 5 Effector Channels -- 6 Additional Receptor-Associated Proteins -- 7 Concluding Remarks -- References -- Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling -- 1 Introduction -- 2 GABABR Structure -- 2.1 Ligand Binding -- 2.2 Coupling to G Proteins -- 2.3 Cell Surface Trafficking -- 2.4 Alternative Splicing -- 2.5 Oligomerization -- 2.6 GABABR Signalosome -- 3 GABABR-Dependent Signaling in Neurons -- 3.1 GABABR Coupling to G Proteins -- 3.2 GABABR Regulation of Effectors -- 3.2.1 GIRK Channels -- 3.2.2 Voltage-Gated Ca2+ Channels -- 3.2.3 Adenylyl Cyclase -- 4 Regulation of GABABR-Dependent Signaling in Neurons -- 4.1 Desensitization -- 4.2 Phosphorylation -- 4.2.1 CaMKII -- 4.2.2 AMPK -- 4.2.3 PKA -- 4.2.4 PKC -- 4.3 Ubiquitination -- 4.4 KCTD Proteins -- 4.5 RGS Proteins -- 4.5.1 R7 RGS/G?5 -- 4.5.2 R4 RGS Proteins -- 4.5.3 RGS12 -- 5 Plasticity of GABABR-Dependent Signaling -- 5.1 Phosphorylation-Dependent Plasticity -- 5.2 Plasticity of 14-3-3 Proteins -- 5.3 Plasticity of RGS Regulation -- 6 Concluding Remarks -- References. 327 $aGABAB Receptor Chemistry and Pharmacology: Agonists, Antagonists, and Allosteric Modulators -- 1 Introduction -- 2 Brief History -- 3 Structure and Signaling -- 4 Molecular Diversity and Complexity -- 5 Agonists -- 6 Partial Agonists -- 7 Antagonists -- 8 Inverse Agonists -- 9 Allosteric Modulators -- 10 Probe Dependency -- 11 Biased Agonism/Functional Selectivity -- 12 GABAB Receptor-Targeted Pharmaceuticals -- 13 Concluding Remarks -- References -- GABAB Receptors and Drug Addiction: Psychostimulants and Other Drugs of Abuse -- 1 Introduction -- 2 GABABR Signaling in the Reward Circuit -- 2.1 The VTA Microcircuit -- 2.2 GABAergic Inputs to the VTA -- 3 Impact of Addictive Drugs on GABABR Signaling in the Reward Circuit -- 3.1 Psychostimulants -- 3.2 Nicotine -- 3.3 Opioids -- 3.4 Cannabis -- 3.5 Summary -- 4 Effects of Genetic Manipulations of GABABR on Animal Models of Drug Addiction -- 5 Effects of Pharmacological Manipulations on Animal Models of Drug Addiction: Agonists, Antagonists, and Positive Allosteric ... -- 5.1 Psychostimulants -- 5.1.1 Amphetamine and Methamphetamine -- 5.1.2 Cocaine -- 5.2 Nicotine -- 5.3 Opioids -- 5.4 Other Drugs/Reinforcers -- 5.5 Stress and Addiction -- 5.6 Summary -- 6 Clinical Studies of GABABR Modulators in Drug Addiction -- 7 Conclusions -- References -- GABAB Receptors and Alcohol Use Disorders: Preclinical Studies -- 1 GABAB Receptors and Alcohol Use Disorders: Preclinical Studies -- 2 Locomotor Activity -- 3 Place Conditioning -- 4 Alcohol Withdrawal Syndrome -- 5 Alcohol Drinking -- 5.1 Acquisition and Maintenance of Alcohol Drinking -- 5.2 Binge-Like Drinking -- 5.3 Relapse-Like Drinking -- 6 Operant Alcohol Self-Administration -- 6.1 Fixed Ratio (FR) Procedure -- 6.2 Progressive Ratio (PR) Procedure -- 6.3 Extinction and Reinstatement of Alcohol Seeking Procedures -- 6.4 Appetitive-Consummatory Procedures. 327 $a7 Discussion -- References -- GABAB Receptors and Alcohol Use Disorders: Clinical Studies -- 1 Introduction -- 2 Overview of Pharmacotherapies Modulating the GABAB Receptor -- 2.1 Baclofen -- 2.2 ?-Hydroxybutyric Acid -- 3 Treatment for Alcohol Withdrawal Syndrome -- 4 Relapse Prevention in Alcohol Use Disorders -- 4.1 Baclofen: Low-to-Moderate Doses -- 4.2 Baclofen: High-Doses -- 4.3 Specific Populations -- 4.3.1 Alcohol-Related Liver Disease -- 4.3.2 Comorbid Anxiety -- 5 Meta-Analyses Assessing Baclofen´s Efficacy -- 6 Laboratory Studies Evaluating Craving and Biobehavioural Effects of Baclofen -- 6.1 Functional Brain Activation Correlates with Baclofen -- 7 Polymorphisms Associated with Baclofen Treatment Response -- 8 Safety Concerns with Baclofen -- 9 Conclusions -- References -- GABAB Receptors and Pain -- 1 Introduction -- 1.1 Pain-Related Terminology -- 2 Expression and Function of GABAB Receptors in Nociceptive Pathways -- 2.1 GABAB Receptors in Nociceptors -- 2.1.1 GABAB Receptors in Peripheral Axon Endings of Nociceptors -- 2.1.2 GABAB Receptors in Central Axon Endings of Nociceptors -- 2.2 GABAB Receptors in Dorsal Horn Interneurons and Projection Neurons -- 2.3 GABAB Receptors in Supraspinal Areas -- 2.4 GABAB Receptors in Descending Pain Control Pathways -- 3 GABAB Receptors and Pathological Pain -- 3.1 GABAB Receptors and Inflammatory Pain -- 3.2 GABAB Receptors and Neuropathic Pain -- 4 GABAB Receptors as Target for Treating Chronic Pain -- 5 Conclusions -- References -- GABAB Receptors: Anxiety and Mood Disorders -- 1 Introduction -- 2 Role of the GABAB Receptor in the Modulation of Anxiety -- 2.1 Effects of GABAB Receptor Agonists and Positive Allosteric Modulators on Anxiety-Like Behaviour -- 2.2 Effects of GABAB Receptor Loss of Function and GABAB Receptor Antagonists on Anxiety-Like Behaviour. 327 $a3 Role of the GABAB Receptor in Depression and Antidepressant Action -- 3.1 Effects of GABAB Receptor Agonists on Depression-Like Behaviour -- 3.2 Effects of GABAB Receptor Blockade or Loss of Function on Depression-Like Behaviour -- 4 Clinical Evidence of the Role of GABAB Receptor in Mood Disorders -- 5 Conclusions and Perspectives -- References -- GABAB Receptors in Neurodegeneration -- 1 Introduction -- 2 GABAB Receptor and Its Effects -- 2.1 K+ Channels -- 2.2 Ca2+ Channels -- 2.3 Inhibition of Adenylate Cyclase -- 3 GABAA Receptors -- 4 GABAB in Neurodegenerative Diseases -- 4.1 GABAB in Alzheimer´s Disease -- 4.2 GABAB in Parkinson´s Disease -- 4.3 GABAB in Temporal Lobe Epilepsy -- 5 Conclusions -- References -- GABAB Receptors and Cognitive Processing in Health and Disease -- 1 Introduction -- 2 GABAB Receptors Mechanisms of Action -- 3 Effects of GABAB Receptors on Cognitive Processes: Learning and Memory -- 3.1 GABAB Receptors, LTP and Synaptic Plasticity -- 3.2 Active and Passive Avoidance Paradigms -- 3.3 Morris Water Maze (MWM) and Radial Arm Maze (RAM) -- 3.4 Working Memory Tasks -- 3.5 Novel-Object Recognition (NOR) and (Dis)Location (NOL) Tasks -- 3.6 Other Cognitive Tasks -- 4 GABABR Involvement in Cognitive Performance of Neurodevelopmental Conditions -- 4.1 GABABRs During Embryo-Foetal Development -- 4.2 Autism Spectrum Disorder (ASD) -- 4.3 Fragile X Syndrome (FXS) -- 4.4 Down´s Syndrome (DS) -- 5 Neurodegenerative Disorders -- 5.1 Alzheimer´s Disease (AD) -- 5.2 Epilepsy -- 5.3 Autoimmune Anti-GABAB Encephalitis and Cognitive Impairments -- 6 Conclusions -- References. 330 $aIt has been almost forty years since Norman G. Bowery discovered and named this ?non-GABAA? receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors. The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives. The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative. 410 0$aCurrent Topics in Behavioral Neurosciences,$x1866-3389 ;$v52 606 $aPharmacology 606 $aNeurosciences 606 $aPsychiatry 606 $aPharmacology 606 $aNeuroscience 606 $aPsychiatry 615 0$aPharmacology. 615 0$aNeurosciences. 615 0$aPsychiatry. 615 14$aPharmacology. 615 24$aNeuroscience. 615 24$aPsychiatry. 676 $a615.78 702 $aVlachou$b Styliani 702 $aWickman$b Kevin D$g(Kevin David), 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910522957003321 996 $aBehavioral Neurobiology of GABAB Receptor Function$92594799 997 $aUNINA