LEADER 04141nam 22006975 450 001 9910522931703321 005 20251113191759.0 010 $a3-030-87845-7 024 7 $a10.1007/978-3-030-87845-0 035 $a(MiAaPQ)EBC6823489 035 $a(Au-PeEL)EBL6823489 035 $a(CKB)20094167400041 035 $a(PPN)259387134 035 $a(OCoLC)1288411766 035 $a(DE-He213)978-3-030-87845-0 035 $a(EXLCZ)9920094167400041 100 $a20211207d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMedicine-Based Informatics and Engineering /$fedited by Franco Simini, Pedro Bertemes-Filho 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (210 pages) 225 1 $aLecture Notes in Bioengineering,$x2195-2728 311 08$aPrint version: Simini, Franco Medicine-Based Informatics and Engineering Cham : Springer International Publishing AG,c2022 9783030878443 327 $aIntroduction -- Medicine Based Engineering and Informatics to Foster Patient Physician Relationship -- Statistical Gait Analysis based on surface electromyography -- Brain-computer interfaces with functional electrical stimulation for motor neurorehabilitation: from research to clinical practice -- Biopotential acquisition systems -- Wearable Bioimpedance Measuring Devices -- Predictive cardiovascular engineering: transforming data into future insights on cardiovascular disease -- Engineering special medical devices for vulnerable groups -- Serious games and virtual reality for rehabilitation and follow up of wheelchaired persons -- Society 5.0 and a Human Centred Health Care. 330 $aThis book originates from the idea to adapt biomedical engineering and medical informatics to current clinical needs and proposes a paradigm shift in medical engineering, where the limitations of technology should no longer be the starting point of design, but rather the development of biomedical devices, software, and systems should stem from clinical needs and wishes. Gathering chapters written by authoritative researchers, working the interface between medicine and engineering, this book presents successful attempts of conceiving technology based on clinical practice. It reports on new strategies for medical diagnosis, rehabilitation, and eHealth, focusing on solutions to foster better quality of life through technology, with an emphasis on patients? and clinical needs, and vulnerable populations. All in all, the book offers a reference guide and a source of inspiration for biomedical engineers, clinical scientists, physicians, and computer scientists. Yet, it alsoincludes practical information for personnel using biomedical equipment, as well as timely insights that are expected to help health agencies and software firms in their decision-making processes. 410 0$aLecture Notes in Bioengineering,$x2195-2728 606 $aBiomedical engineering 606 $aMedical informatics 606 $aBiology$xTechnique 606 $aBiophysics 606 $aClinical medicine$xResearch 606 $aMedical and Health Technologies 606 $aHealth Informatics 606 $aBiomedical Devices and Instrumentation 606 $aBiophysical Methods 606 $aClinical Research 615 0$aBiomedical engineering. 615 0$aMedical informatics. 615 0$aBiology$xTechnique. 615 0$aBiophysics. 615 0$aClinical medicine$xResearch. 615 14$aMedical and Health Technologies. 615 24$aHealth Informatics. 615 24$aBiomedical Devices and Instrumentation. 615 24$aBiophysical Methods. 615 24$aClinical Research. 676 $a610.285 702 $aBertemes-Filho$b Pedro 702 $aSimini$b Franco 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910522931703321 996 $aMedicine-Based Informatics and Engineering$94464621 997 $aUNINA LEADER 04250nam 22006975 450 001 9910855369203321 005 20250807133256.0 010 $a9783031511714 024 7 $a10.1007/978-3-031-51171-4 035 $a(CKB)31801413800041 035 $a(MiAaPQ)EBC31313098 035 $a(Au-PeEL)EBL31313098 035 $a(DE-He213)978-3-031-51171-4 035 $a(OCoLC)1432600255 035 $a(EXLCZ)9931801413800041 100 $a20240430d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCryo-Electron Tomography $eStructural Biology in situ /$fedited by Friedrich Förster, Ariane Briegel 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (391 pages) 225 1 $aFocus on Structural Biology,$x2542-9566 ;$v11 311 08$a9783031511707 327 $a1. Fundamentals of Instrumentation and electron optics For cryo-electron tomography -- 2. Principles of tomographic reconstruction -- 3. Cryo-preparation for cellular tomography -- 4. Cryo-FIB milling -- 5. In Situ Cryo-Electron Tomography and Advanced Micromanipulator Techniques -- 6. Labeling approaches and correlation with light microscopy (Cryo) CLEM -- 7. Data collection -- 8. Subvolume averaging and classification -- 9. High resolution tomography/ Molecular model building and visualization -- 10. Beam-induced Motion Mechanism and Correction for Improved Cryo-Electron Microscopy and Cryo-Electron Tomography -- 11. Tomogram segmentation -- 12. Electron tomography of cryo-fixed and resin-embedded samples -- 13. Democratization of tomographic data / FAIR data. 330 $aThis book presents key aspects and recent developments of cryogenic sample electron tomography (cryo-ET) methodology, authored by leading experts in the field. Understanding structure and function of biomolecules in the context of cells is a new frontier in cellular and structural biology. To facilitate such research, cryo-ET is a key method to visualize the molecules of life in their native settings. Cryo-ET enables the imaging of samples that are preserved in a near-native state, at (macro)-molecular resolution and in three dimensions. Thus, this technique is a unique tool to gain insights into how biomolecules collaborate in orchestrating fundamental biological processes, how mutations cause diseases, pathogens cause infections, and to develop novel therapeutics to treat such illnesses. This book provides a unique reference for the emerging field of cryo-ET. The topics covered range from the fundamental principles of imaging to sample preparation, data analysis, and data sharing within the scientific community. It serves as a valuable resource for the next generation of structural biologists, making it suitable both for undergraduate students studying biochemistry, biophysics, and molecular biology and highly valuable for the more experienced and specialized PhD student. Furthermore, it stands as a state-of-the?art source of knowledge for the established senior scientist within the field of structural biology. 410 0$aFocus on Structural Biology,$x2542-9566 ;$v11 606 $aBiomolecules 606 $aPhysical biochemistry 606 $aMacromolecules 606 $aBiology$xTechnique 606 $aBiophysics 606 $aImmunology 606 $aMaterials$xMicroscopy 606 $aStructural Biology 606 $aBiophysical Methods 606 $aImmunology 606 $aMicroscopy 615 0$aBiomolecules. 615 0$aPhysical biochemistry. 615 0$aMacromolecules. 615 0$aBiology$xTechnique. 615 0$aBiophysics. 615 0$aImmunology. 615 0$aMaterials$xMicroscopy. 615 14$aStructural Biology. 615 24$aBiophysical Methods. 615 24$aImmunology. 615 24$aMicroscopy. 676 $a616.0757 700 $aFörster$b Friedrich$0561355 701 $aBriegel$b Ariane$01737786 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910855369203321 996 $aCryo-Electron Tomography$94159707 997 $aUNINA