LEADER 04983nam 22006615 450 001 9910522928003321 005 20251202150656.0 010 $a3-030-86705-6 024 7 $a10.1007/978-3-030-86705-8 035 $a(MiAaPQ)EBC6816987 035 $a(Au-PeEL)EBL6816987 035 $a(CKB)19934882800041 035 $a(OCoLC)1287130205 035 $a(PPN)258844973 035 $a(BIP)82373869 035 $a(BIP)81250334 035 $a(DE-He213)978-3-030-86705-8 035 $a(EXLCZ)9919934882800041 100 $a20211127d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFeatures and Management of Acute and Chronic Neuro-Covid /$fby Marco Cascella, Elvio De Blasio 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (172 pages) 311 08$aPrint version: Cascella, Marco Features and Management of Acute and Chronic Neuro-Covid Cham : Springer International Publishing AG,c2022 9783030867041 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Part I. Pathophysiology of COVID-19-associated neurotoxicity -- An update on preclinical findings -- Ongoing clinical investigations -- Perspectives -- Part II. Clinical manifestations of acute neurotoxicity -- Clinical features -- CNS complications -- PNS complications -- Diagnosis.-Management -- Perspectives -- Part III. Neurological and psychiatric sequelae in COVID-19 survivors.-Clinical features -- Neurological late complications -- psychological and psychiatric sequelae.-Diagnosis -- Tools -- The role of imaging -- Preventive strategies -- Social and economic impact.-Multidisciplinary management -- Perspectives. 330 $aThis book underlines how COVID-19 is a multisystem inflammatory disease and how its pathophysiology can predispose to an increased risk of neurological issues. Several scientific pieces of evidence showes the mechanisms underlying the neuroinvasive capacity of the SARS-CoV-2 through direct viral damage and indirect processes entering the CNS by different routes including the vasculature, the olfactory and trigeminal nerves, the cerebrospinal fluid, and the lymphatic system inducing a direct neurotoxicity. Furthermore, the pro-inflammatory cytokine storm and oxidative stress can induce microglial activation and damage to the blood-brain barrier, culminating in widespread neuroinflammatory process. This acute neurotoxicity is clinically expressed as anosmia and ageusia, headache, nausea and vomiting, but other neurologic manifestations such as acute cerebrovascular diseases, consciousness impairment due to encephalitis, and meningitis are also described. The PNS can also beaffected by infectious damage and clinical manifestations including Guillain-Barré syndrome, polyneuritis cranialis, and Miller Fisher Syndrome. A special issue concerns the neurocognitive dysfunction and altered consciousness manifested as delirium, agitation and confusion. Non-specific symptoms such as dizziness, seizures can accompany clinical pictures. Regardless of the admission diagnosis, a high percentage of patients discharged from ICUs develop disabilities affecting physical, cognitive and psychological activities. The symptoms such as asthenia, memory disturbances, depression, sleep disturbances, anxiety, and Post-traumatic stress disorder (PTSD), configure the so-called Post-intensive Care Syndrome (PICS). Multimodal management during the ICU stay and implementation of follow-up programs at patient discharge can reduce the incidence of this syndrome, improving the quality of life of surviving patients. In this complex scenario, a careful clinical approach through reliable diagnostic tools, and epidemiological studies aimed at evaluating the dimensions of the problem also in economic terms, is urgently needed. This book represents a valuable aid for all those healthcare professionals (intensivists, neurologist and psychiatrists, as well) involved in the management of these critically ill patients. 606 $aCritical care medicine 606 $aNeurology 606 $aPsychiatry 606 $aPublic health 606 $aIntensive Care Medicine 606 $aNeurology 606 $aPsychiatry 606 $aPublic Health 615 0$aCritical care medicine. 615 0$aNeurology. 615 0$aPsychiatry. 615 0$aPublic health. 615 14$aIntensive Care Medicine. 615 24$aNeurology. 615 24$aPsychiatry. 615 24$aPublic Health. 676 $a616.2414 700 $aCascella$b Marco$01062882 702 $aDe Blasio$b Elvio 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910522928003321 996 $aFeatures and Management of Acute and Chronic Neuro-Covid$92589487 997 $aUNINA