LEADER 00928nam0 2200313 450 001 9910515108103321 005 20220610105741.0 010 $a9788855194464 100 $a20220113d2021----km y0itay50 ba 101 1 $aita$ceng 102 $aIT 105 $a 001yy 200 1 $a<>vita sociale delle cose$euna prospettiva culturale sulle merci di scambio$fa cura di Arjun Appadurai 210 $aMilano$cMeltemi$d2021 215 $a474 p.$d21 cm 225 1 $aBiblioteca$iAntropologia$v48 454 0$1990003742150403321 610 0 $aOggetti$aAspetti socioculturali 676 $a306.3$v22$zita 700 1$aAppadurai,$bArjun$0141894 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910515108103321 952 $a306.3 APPA 01$b2022/243$fFLFBC 952 $a306.3 APP 2$b8899$fBFS 959 $aFLFBC 959 $aBFS 996 $aVita sociale delle cose$92569978 997 $aUNINA LEADER 04559nam 22006015 450 001 9910349284303321 005 20200703065947.0 010 $a3-030-22005-2 024 7 $a10.1007/978-3-030-22005-1 035 $a(CKB)4100000009184421 035 $a(DE-He213)978-3-030-22005-1 035 $a(MiAaPQ)EBC5890671 035 $a(PPN)24282160X 035 $a(EXLCZ)994100000009184421 100 $a20190903d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBile Acids and Their Receptors /$fedited by Stefano Fiorucci, Eleonora Distrutti 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (X, 378 p. 57 illus., 37 illus. in color.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v256 311 $a3-030-22004-4 327 $aPreface -- Part 1. Bile acids as signaling molecules and their receptors -- 1. A short history of bile acid pharmacology -- 2. Bile acids activated receptors: a review of GPBAR1 (TGR5) and other G-protein-coupled receptors -- 3. Bile acid activated receptors: a review of FXR and other Nuclear receptors -- 4. The intestinal enterokine fibroblast growth factor 15/19 in bile acid metabolism -- 5. Signaling from intestine to the host. How bile acids regulate intestinal and liver immunity -- Part 2. General pharmacology of bile acid activated receptors and their ligands -- 6. Modeling of bile acid activated receptors as a tool for pharmacological development -- 7. Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists and antagonists -- 8. Non steroidal FXR ligands: current status and clinical applications -- 9. Intestinal selective FXR agonists and their potential in treating liver and metabolic diseases -- Part 3. Bile acids and their derivatives as drugs -- 10. UDCA, Nor-UDCA and T-UDCA: a review of their mechanisms of action and clinical applications -- 11. Chenodeoxycholic acid: an update on its therapeutic appplications and safety profile -- 12. Obeticholic acid: a review of its mechanisms of action and clinical applications -- Part 4. Bile acid activated receptors as therapeutic targets -- 13. Targeting FXR in cholestasis -- 14. FXR agonists for the treatment of NASH and other metabolic disorders -- 15. Targeting bile acids activated receptors in bariatric surgery. 330 $aThis book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis. . 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v256 606 $aPharmacology 606 $aGastroenterology 606 $aHepatology 606 $aEndocrinology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061 606 $aHepatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33088 606 $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053 615 0$aPharmacology. 615 0$aGastroenterology. 615 0$aHepatology. 615 0$aEndocrinology. 615 14$aPharmacology/Toxicology. 615 24$aGastroenterology. 615 24$aHepatology. 615 24$aEndocrinology. 676 $a615 676 $a612.35 702 $aFiorucci$b Stefano$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDistrutti$b Eleonora$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910349284303321 996 $aBile acids and their receptors$91765549 997 $aUNINA