LEADER 04757nam 22007455 450 001 9910502997103321 005 20250204003831.0 010 $a9783030783976 010 $a3030783979 024 7 $a10.1007/978-3-030-78397-6 035 $a(CKB)4100000012037057 035 $a(MiAaPQ)EBC6734887 035 $a(Au-PeEL)EBL6734887 035 $a(OCoLC)1269482277 035 $a(PPN)258052244 035 $a(DE-He213)978-3-030-78397-6 035 $a(EXLCZ)994100000012037057 100 $a20210926d2021 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHeat Shock Proteins of Malaria /$fedited by Addmore Shonhai, Didier Picard, Gregory L. Blatch 205 $a2nd ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (256 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1340 311 08$a9783030783969 311 08$a3030783960 320 $aIncludes bibliographical references and index. 327 $aChapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum -- Chapter 2. General Structural and Functional Features of Molecular Chaperones -- Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum -- Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria -- Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells -- Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria -- Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery? -- Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery -- Chapter 10 -- Heat Shock Proteins of Malaria: Highlights and Future Prospects. 330 $aThis new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer?s Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1340 606 $aParasitology 606 $aProteins 606 $aMolecular biology 606 $aCytology 606 $aTropical medicine 606 $aParasitology 606 $aProtein Biochemistry 606 $aMolecular Biology 606 $aCell Biology 606 $aTropical Medicine 615 0$aParasitology. 615 0$aProteins. 615 0$aMolecular biology. 615 0$aCytology. 615 0$aTropical medicine. 615 14$aParasitology. 615 24$aProtein Biochemistry. 615 24$aMolecular Biology. 615 24$aCell Biology. 615 24$aTropical Medicine. 676 $a614.532 702 $aPicard$b Didier 702 $aBlatch$b Gregory L. 702 $aShonhai$b Addmore 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910502997103321 996 $aHeat Shock Proteins of Malaria$92569323 997 $aUNINA