LEADER 11384nam 2200625 450 001 9910502662203321 005 20230503113338.0 010 $a3-030-76136-3 035 $a(CKB)4940000000612691 035 $a(MiAaPQ)EBC6730624 035 $a(Au-PeEL)EBL6730624 035 $a(OCoLC)1268983476 035 $a(PPN)258056940 035 $a(EXLCZ)994940000000612691 100 $a20220622d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTranscranial direct current stimulation in neuropsychiatric disorders $eclinical principles and management /$fedited by Andre? R. Brunoni, Michael A. Nitsche, and Colleen K. Loo 205 $aSecond edition. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (779 pages) 300 $aIncludes index. 311 $a3-030-76135-5 327 $aIntro -- Foreword to the Second Edition -- Reference -- Foreword to the First Edition -- References -- Preface to the Second Edition -- Preface to the First Edition -- Contents -- Contributors -- Part I: Introduction and Mechanisms of Action -- 1: Historical Aspects of Transcranial Electric Stimulation -- 1.1 The First Clinical-Therapeutic Electrical Applications: The Electric Fish -- 1.2 Transcranial Electrical Stimulation: From Electrostatic Machines to Volta's Pile -- 1.3 The Reappraisal of Transcranial Direct Current Stimulation (tDCS) from 1960 Onward -- 1.4 Concluding Remarks -- References -- 2: Basic Mechanisms of Transcranial Alternating Current and Random Noise Stimulation -- 2.1 Introduction -- 2.2 Neurophysiological Effects -- 2.3 Evidence in Humans -- 2.4 Distinct tACS Variants -- 2.5 Clinical Applications -- 2.6 Conclusion -- References -- 3: Physiology of Transcranial Direct and Alternating Current Stimulation -- 3.1 Introduction -- 3.2 tDCS -- 3.2.1 tDCS Protocols and Effects -- Electrode Position/Configuration/Current Direction -- Current Intensity/Density -- Stimulation Duration/Interval -- 3.2.2 tDCS Physiology -- Regional Effects of tDCS -- Acute Alteration of Cortical Excitability -- Sustained Change of Cortical Excitability and Activity -- Pharmacology of tDCS -- tDCS Effect on Cortical Regions Other than M1 -- Inter-Regional Effects of tDCS -- 3.3 tACS -- 3.3.1 tACS Protocols and Effects -- Physiological Effects of tACS -- tACS Effects on Cognition and Behaviour -- 3.4 General Remarks -- References -- 4: Animal Models of tES: Methods, Techniques, and Safety -- 4.1 Methods -- 4.2 Modes of Noninvasive Electrical Brain Stimulation -- 4.3 Stimulation Artifact in Recording -- 4.4 Safety -- 4.4.1 Dose-Response and Safety -- 4.4.2 Safety Limits for Tissue Injury -- 4.5 The Quasi-Uniform Assumption. 327 $a4.6 Dose Translation and Meaningful Animal Studies -- References -- 5: Animal Studies on the Mechanisms of Low-Intensity Transcranial Electric Stimulation -- 5.1 Neuronal Polarization and Need for Amplification -- 5.1.1 The Somatic Doctrine -- 5.1.2 Early Evidence on Modulation of Excitability, Polarity-Specific Effects -- 5.1.3 Polarization of Nonsomatic Components -- 5.1.4 Membrane Polarization and Coupling Constants -- 5.1.5 Amplification Through Both Timing and Rate -- 5.1.6 Seizure Threshold and Modulation -- 5.2 Synaptic Processing and Plasticity -- 5.2.1 Paradigms for Modulation of Synaptic Plasticity by Electric Stimulation -- 5.2.2 Effects of Direct Current Stimulation on LTP and LTD In Vitro -- 5.2.3 Molecular Mechanisms of tES-Induced Effects on Synaptic Plasticity -- 5.3 Morphological Changes -- 5.4 Network Effects -- 5.5 Interneurons and Nonneuronal Effects -- 5.5.1 Interneurons -- 5.5.2 Glia -- 5.5.3 Inflammation, Angiogenesis, and Apoptosis -- 5.6 Applications to Clinical Pathologies -- 5.6.1 Stroke -- 5.6.2 Addiction -- 5.6.3 Alzheimer's Disease -- 5.6.4 Chronic Stress and Depression -- 5.7 Prospects for Animal Research in tDCS/tACS Informing Ongoing Human Trials -- References -- Part II: Research Methods -- 6: TMS-Evoked EEG Response in Neuropsychiatric Disorders -- 6.1 Introduction -- 6.2 Technical Aspects -- 6.2.1 General Issues -- 6.2.2 EEG Artifacts -- 6.2.3 Outcome Measures -- 6.3 Physiology -- 6.4 Neuropsychiatry -- 6.4.1 Attention-Deficit/Hyperactivity Disorder (ADHD) -- 6.4.2 Schizophrenia -- 6.4.3 Mood Disorders -- 6.4.4 Substance Abuse Disorders -- 6.4.5 Alzheimer's Disease (AD) -- 6.5 Future Directions -- References -- 7: Multimodal Association of tDCS with Electroencephalography -- 7.1 Introduction: A Brief Picture of the Present State of Research. 327 $a7.2 Principles of Multimodal Association -- 7.3 Advantages of Combining tES with Other Methods -- 7.4 Technical Aspects for the Combined Use of tES and EEG -- 7.5 tDCS-EEG in Studying Cortical Excitability, Connectivity and Plasticity -- 7.6 Multimodal Imaging as a Diagnostic/Prognostic Tool in Neuropsychiatric Disorders -- 7.7 Conclusions and Final Remarks -- References -- 8: tDCS and Magnetic Resonance Imaging -- 8.1 Introduction -- 8.2 Combining tDCS and MRI -- 8.3 Functional Magnetic Resonance Imaging -- 8.4 BOLD Functional MRI -- 8.4.1 Resting-State fMRI -- tDCS Has Significant, but Somewhat Unclear, Effects on Resting Functional Connectivity -- tDCS As a Potential Tool to Understand the Basis of Resting Functional Connectivity -- 8.4.2 Task-Based fMRI -- Studies in Healthy Controls -- 8.4.3 Arterial Spin Labelling (ASL) -- 8.5 Magnetic Resonance Spectroscopy -- 8.5.1 1H-MRS -- Neurochemicals of Interest -- Glutamate -- GABA -- N-Acetylaspartic Acid and Creatine -- 8.5.2 31P-MRS -- 8.5.3 Combining tDCS with MRS -- 8.6 Current Density and Impedance Imaging -- 8.7 Conclusions and Future Directions -- References -- 9: tDCS and Functional Connectivity -- 9.1 Introduction -- 9.2 Motor Cortex -- 9.2.1 Effects of Anodal tDCS -- 9.2.2 Effects of Cathodal tDCS -- 9.2.3 Effects of Dual tDCS -- 9.3 Prefrontal tDCS -- 9.3.1 Prefrontal tDCS and Cognitive/Executive Functions -- 9.3.2 Prefrontal tDCS and Resting-State Network -- 9.4 Therapeutic Application of tDCS -- 9.4.1 Neurological Disorders -- Stroke -- Language Deficits -- 9.4.2 Psychiatric Disorders -- Schizophrenia -- Major Depressive Disorder -- 9.5 Effect Variability and Test-Retest Reliability of tDCS -- 9.6 Association Between Response Patterns and Baseline MRI Markers -- 9.7 Conclusions and Future Directions -- References. 327 $a10: The Value of Neuroimaging for Treating Depression with Brain Stimulation -- 10.1 Introduction -- 10.1.1 Non-invasive Brain Stimulation to Treat Depression -- 10.1.2 Network Theories of Depression -- 10.1.3 Why Combine NIBS and Neuroimaging? -- How Can NIBS Reach Deep Brain Regions? -- Contributions of Neuroimaging to the Clinical Application of NIBS -- 10.2 Does Neuroimaging-Guided Brain Target Localization Improve Treatment? -- 10.2.1 TMS -- Does Localization Accuracy Matter? -- 10.2.2 tDCS -- Neuroimaging Is Necessary to Test for Target Engagement -- 10.2.3 Summary -- 10.3 Mechanisms of NIBS Treatment -- 10.3.1 Effects on Brain Metabolism -- Physiological Effects of the Two Standard TMS Approaches -- Critical Assessment of the Reported Literature -- 10.3.2 Effects on Brain Networks in the Resting State -- TMS Effects on Resting-State Networks -- The Clinical Effect of TMS Is Associated with Connectivity Changes in the Subgenual ACC -- TMS Effects on the Three Major Resting-State Networks -- tDCS Effects on Resting-State Networks -- TDCS Effects on the Three Major Resting-State Networks -- Resting-State Analysis Suggests Alternative Target Regions -- 10.3.3 Physiological Effects During Concurrent NIBS and fMRI -- The Value of Measuring the Direct Physiological Effects of NIBS -- 10.3.4 Effects on Task fMRI -- 10.3.5 Structural Changes in Response to NIBS Treatment -- 10.3.6 Summary -- 10.4 Predictors of Treatment Response -- 10.4.1 Predictors Based on PET -- 10.4.2 Predictors Based on Resting-State Connectivity -- 10.4.3 Predictors Based on Task-Related Activity -- 10.4.4 Structural Predictors -- 10.4.5 Summary -- 10.5 Individualized Treatment -- 10.5.1 Adjusting the Target Region Based on Individual Anatomy -- 10.5.2 Categorization into Different Subtypes of Depression -- 10.5.3 Summary. 327 $a10.6 Conclusions and Challenges -- References -- 11: Target Engagement with Transcranial Current Stimulation -- 11.1 Mechanistic Insights from Animal Studies -- 11.1.1 Effect of Electric Fields on Individual Neurons -- 11.1.2 TES Effect on Neuronal Firing Rate and Spike Timing -- 11.1.3 Interactions of Network Oscillations and Electric Fields -- 11.1.4 Outlasting Effects of Electric Fields -- 11.1.5 Interaction of Cellular and Network Mechanisms -- 11.2 Computational Models -- 11.2.1 Forward Models -- 11.2.2 Computational Neural Models -- 11.2.3 Future Directions -- 11.3 Effects of Weak Electric Fields on the Human Brain -- 11.3.1 Neurophysiology of tDCS in Humans -- 11.3.2 Mechanisms of tDCS in Humans -- 11.3.3 Neurophysiology of tACS in Humans -- 11.3.4 Mechanism of tACS in Humans -- 11.4 Spatial and Temporal Targeting to Improve Cognition -- 11.4.1 Frequency-Specific Effects of tACS -- 11.4.2 High-Density Spatial Targeting -- 11.4.3 Cross-Frequency tACS -- 11.5 Application of tES to Sleep Oscillations -- 11.5.1 Mechanisms of Slow Oscillations -- 11.5.2 Modulating the Slow Oscillation with Weak Electric Fields -- 11.6 Clinical Trials of tACS -- 11.7 Outlook -- References -- 12: Cerebellar and Spinal tDCS -- 12.1 Cerebellar Transcranial Direct Current Stimulation: Technique's Overview and Clinical Applications -- 12.2 Transcutaneous Spinal Direct Current Stimulation: Technique's Overview -- 12.3 Mechanisms of Action -- 12.3.1 Putative Mechanisms of Action at a Spinal Level -- 12.3.2 Putative Mechanisms of Action at a Supraspinal Level -- 12.4 Perspective on Clinical Studies -- 12.5 Why Should Psychiatrists Be Interested in Cerebellar/Spinal DC Stimulation? -- References -- 13: Precision Targeting of Neural Networks with tDCS Informed by Brain Mapping -- 13.1 Introduction. 327 $a13.1.1 Identifying and Targeting Dysfunctional Large-Scale Brain Networks. 606 $aMental illness$xTreatment 606 $aMagnetic brain stimulation 606 $aPsychology, Pathological$xTreatment 606 $aPsicopatologia$2thub 606 $aEstimulació del cervell$2thub 608 $aLlibres electrňnics$2thub 615 0$aMental illness$xTreatment. 615 0$aMagnetic brain stimulation. 615 0$aPsychology, Pathological$xTreatment. 615 7$aPsicopatologia 615 7$aEstimulació del cervell 676 $a612.822 702 $aBrunoni$b Andre? 702 $aNitsche$b Michael$f1968- 702 $aLoo$b Colleen 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910502662203321 996 $aTranscranial Direct Current Stimulation in Neuropsychiatric Disorders$92568788 997 $aUNINA