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024 7 $a10.1007/978-3-030-87324-0
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101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aSARS-CoV-2 Spike Protein Convergent Evolution $eImpact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines /$fby Daniele Focosi
205   $a1st ed. 2021.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021.
215   $a1 online resource (140 pages)
225 1 $aSpringerBriefs in Microbiology,$x2191-5393
311 08$a3-030-87323-4 
327   $aChapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.
330   $aThis book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
410  0$aSpringerBriefs in Microbiology,$x2191-5393
606   $aVirology
606   $aImmunology
606   $aMedical microbiology
606   $aMicrobial genetics
606   $aVirology
606   $aImmunology
606   $aMedical Microbiology
606   $aMicrobial Genetics
615  0$aVirology.
615  0$aImmunology.
615  0$aMedical microbiology.
615  0$aMicrobial genetics.
615 14$aVirology.
615 24$aImmunology.
615 24$aMedical Microbiology.
615 24$aMicrobial Genetics.
676   $a614.592414
700   $aFocosi$b Daniele$01072599
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910502636203321
996   $aSARS-CoV-2 Spike Protein Convergent Evolution$92568871
997   $aUNINA