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200 10$aEpigenetics and Proteomics of Leukemia $eA Synergy of Experimental Biology and Computational Informatics /$fby R¯uta Navakauskien?e, Dalius Navakauskas, Veronika Borutinskait?e, Dalius Matuzevi?cius
205   $a1st ed. 2021.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021.
215   $a1 online resource (453 pages)
311 08$a3-030-68707-4 
327   $aIntroduction -- Epigenetics in Leukemia -- Genetic and Epigenetic Alterations in Leukemia -- Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment -- Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation -- DNA Methylation and Epigenetic Regulation -- Chromatin Functional Regulation by Histone Modification -- Approaches to Epigenetic Treatment of Leukemia -- Proteomics in Leukemia -- Proteome in Leukemic vs. Differentiated Leukemia Cells -- Protein Phosphorylation in Leukemia -- Computational Methods for Proteome Analysis -- 2DE Fractionation and Visualization -- Proteomic Data Processing -- Proteomic Data Analysis -- Image Acquisition and Data Analysis -- Image Acquisition and Data Analysis -- Protein Localization in Leukemia -- Protein Translocation into the Nucleus during Leukemia Cell Differentiation -- Protein Visualization in Leukemic Cells -- Computational Methods for Protein Localization Estimation -- Fluorescent Image Processing -- Fluorescent Image Acquisition and Analysis -- Future Therapy in Leukemia -- Index.
330   $aThis book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.
606   $aLife sciences
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aBiotechnology
606   $aGenetics
606   $aBioinformatics
606   $aBiomedical engineering
606   $aLife Sciences
606   $aBiomedical Research
606   $aBiotechnology
606   $aGenetics and Genomics
606   $aComputational and Systems Biology
606   $aBiomedical Engineering and Bioengineering
615  0$aLife sciences.
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615  0$aBiotechnology.
615  0$aGenetics.
615  0$aBioinformatics.
615  0$aBiomedical engineering.
615 14$aLife Sciences.
615 24$aBiomedical Research.
615 24$aBiotechnology.
615 24$aGenetics and Genomics.
615 24$aComputational and Systems Biology.
615 24$aBiomedical Engineering and Bioengineering.
676   $a616.99416042
700   $aNavakauskiene?$b Ru?ta$01070294
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906   $aBOOK
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996   $aEpigenetics and Proteomics of Leukemia$92558149
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