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010   $a9783030818654
010   $a3030818659
024 7 $a10.1007/978-3-030-81865-4
035   $a(CKB)5140000000014220
035   $a(MiAaPQ)EBC6784045
035   $a(Au-PeEL)EBL6784045
035   $a(OCoLC)1277277639
035   $a(PPN)258302526
035   $a(DE-He213)978-3-030-81865-4
035   $a(EXLCZ)995140000000014220
100   $a20211015d2021      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAnalysis of Data from Randomized Controlled Trials $eA Practical Guide /$fby Jos W.R. Twisk
205   $a1st ed. 2021.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021.
215   $a1 online resource (167 pages)
311 08$a9783030818647 
311 08$a3030818640 
320   $aIncludes bibliographical references and index.
327   $aIntroduction -- Analysis of RCT data with one follow-up measurement -- Analysis of RCT data with more than one follow-up measurement -- Analysis of data from a cluster RCT -- Analysis of data from a cross-over trial -- Analysis of data from stepped wedge trials -- Analysis of data from N-of-1 trials -- Dichotomous outcomes -- What to do when only a baseline measurement is available -- Sample size calculations.
330   $aThis book provides a practical guide to the analysis of data from randomized controlled trials (RCT). It gives an answer to the question of how to estimate the intervention effect in an appropriate way. This problem is examined for different RCT designs, such as RCTs with one follow-up measurement, RCTs with more than one follow-up measurement, cluster RCTs, cross-over trials, stepped wedge trials, and N-of-1 trials. The statistical methods are explained in a non-mathematical way and are illustrated by extensive examples. All datasets used in the book are available for download, so readers can reanalyse the examples to gain a better understanding of the methods used. Although most examples are taken from epidemiological and clinical studies, this book is also highly recommended for researchers working in other fields.
606   $aStatistics
606   $aClinical medicine$xResearch
606   $aBiometry
606   $aExperimental design
606   $aStatistical Theory and Methods
606   $aClinical Research
606   $aBiostatistics
606   $aDesign of Experiments
615  0$aStatistics.
615  0$aClinical medicine$xResearch.
615  0$aBiometry.
615  0$aExperimental design.
615 14$aStatistical Theory and Methods.
615 24$aClinical Research.
615 24$aBiostatistics.
615 24$aDesign of Experiments.
676   $a616.027
700   $aTwisk$b Jos W. R.$f1962-$01137751
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910502594203321
996   $aAnalysis of data from randomized controlled trials$92897781
997   $aUNINA