LEADER 03006 am 2200517 n 450 001 9910496043803321 005 20201208 010 $a979-1-03-656541-0 024 7 $a10.4000/books.oep.14692 035 $a(CKB)4100000011665481 035 $a(FrMaCLE)OB-oep-14692 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84101 035 $a(PPN)252448197 035 $a(EXLCZ)994100000011665481 100 $a20201218j|||||||| ||| 0 101 0 $afre 135 $auu||||||m|||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aQu?est-ce que le travail scientifique des données ? $eBig data, little data, no data /$fChristine L. Borgman 210 $aMarseille $cOpenEdition Press$d2020 215 $a1 online resource (420 p.) 225 1 $aEncyclopédie numérique 311 $a979-1-03-655038-6 330 $aPuisant ses analyses et ses exemples dans des champs scientifiques variés, cet ouvrage (dont l?original est paru en 2015 chez MIT Press) offre une étude inédite des utilisations des données au sein des infrastructures de la connaissance ? utilisations qui varient largement d?une discipline à l?autre. Bien que le big data ait régulièrement les honneurs de la presse des deux côtés de l?Atlantique, Christine L. Borgman met en évidence qu?il vaut mieux disposer des bonnes données qu?en avoir beaucoup. Elle montre également que les little data peuvent s?avérer aussi précieuses que les big data, et, que, dans bien des cas, il n?y a aucune donnée, parce que les informations pertinentes n?existent pas, sont introuvables ou sont indisponibles? Au travers d?études de cas pratiques issus d?horizons divers, Christine L. Borgman met aussi en lumière que les données n?ont ni valeur ni signification isolément : elles s?inscrivent au sein d?une infrastructure de la connaissance, c?est-à-dire d?un écosystème de personnes, de pratiques, de technologies, d?institutions, d?objets matériels et de relations. Pour l?autrice, gérer les données et les exploiter sur le long terme requiert ainsi des investissements massifs dans ces infrastructures de la connaissance. L?avenir de la recherche, dans un monde en réseau, en dépend. 606 $aInformation Science & Library Science 606 $adonnées 606 $abig data 606 $arecherche 606 $ainfrastructure de la connaissance 610 $adonnées 610 $abig data 610 $arecherche 610 $ainfrastructure de la connaissance 615 4$aInformation Science & Library Science 615 4$adonnées 615 4$abig data 615 4$arecherche 615 4$ainfrastructure de la connaissance 700 $aBorgman$b Christine L$0627824 801 0$bFR-FrMaCLE 906 $aBOOK 912 $a9910496043803321 996 $aQu?est-ce que le travail scientifique des données$93020633 997 $aUNINA LEADER 04160nam 22006015 450 001 9910874676403321 005 20250807132521.0 010 $a9783031551635$b(electronic bk.) 010 $z9783031551628 024 7 $a10.1007/978-3-031-55163-5 035 $a(MiAaPQ)EBC31538227 035 $a(Au-PeEL)EBL31538227 035 $a(CKB)33101362300041 035 $a(DE-He213)978-3-031-55163-5 035 $a(OCoLC)1449645789 035 $a(EXLCZ)9933101362300041 100 $a20240719d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Mechanisms Determining Mammalian Oocyte Quality $eOocyte Developmental Competence, Aneuploidy, and Clinical Relevance /$fedited by Ahmed Z. Balboula 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (135 pages) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v238 311 08$aPrint version: Balboula, Ahmed Z. Molecular Mechanisms Determining Mammalian Oocyte Quality Cham : Springer International Publishing AG,c2024 9783031551628 327 $aChapter 1. Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality -- Chapter 2. Regulation of Oocyte mRNA Metabolism: A Key Determinant of Oocyte Developmental Competence -- Chapter 3. Mechanisms of DNA Damage Response in Mammalian Oocytes -- Chapter 4. How do Environmental Toxicants Affect Oocyte Maturation via Oxidative Stress? -- Chapter 5. Molecular Mechanisms Determining Mammalian Oocyte Quality with the Treatment of Cancer Therapy -- Chapter 6. Telomere Elongation during Pre-implantation Embryo Development. 330 $aAs the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms. Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes. This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis. 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v238 606 $aReproduction 606 $aPhysiology 606 $aCytology 606 $aReproductive health 606 $aReproductive Physiology 606 $aCell Biology 606 $aReproductive Medicine 615 0$aReproduction. 615 0$aPhysiology. 615 0$aCytology. 615 0$aReproductive health. 615 14$aReproductive Physiology. 615 24$aCell Biology. 615 24$aReproductive Medicine. 676 $a599 700 $aBalboula$b Ahmed Z$01749220 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910874676403321 996 $aMolecular Mechanisms Determining Mammalian Oocyte Quality$94183254 997 $aUNINA