LEADER 03369 am 2200709 n 450 001 9910495907903321 005 20210301 010 $a2-38185-020-1 024 7 $a10.4000/books.puc.13392 035 $a(CKB)5590000000436993 035 $a(FrMaCLE)OB-puc-13392 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/86133 035 $a(PPN)254147704 035 $a(EXLCZ)995590000000436993 100 $a20210222j|||||||| ||| 0 101 0 $afre 135 $auu||||||m|||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aLes carnets aujourd?hui $eOutils d?apprentissage et objets de recherche /$fSophie Hébert-Loizelet, Élise Ouvrard 210 $aCaen $cPresses universitaires de Caen$d2021 215 $a1 online resource (212 p.) 225 1 $aSymposia 311 $a2-84133-935-1 330 $aPetit objet nomade à l?apparence souvent anodine, le carnet a dévoilé au fil du temps ses nombreuses potentialités matérielles et créatives, exploitées autant par les écrivains que les scientifiques, autant par les artistes que les théoriciens. L?exploration de ces potentialités en contexte d?apprentissage ou de formation réunit, depuis 2012, des chercheurs et des enseignants à l?école supérieure du professorat et de l?éducation (ESPE) de l?université de Caen Normandie. Leurs échanges et leurs réflexions ont fait émerger trois dimensions clés du carnet : la construction d?un sujet lecteur / scripteur à partir de carnets de lecture ou d?écriture, l?apprentissage (inter)disciplinaire facilité par l?utilisation du carnet en classe, et enfin les liens complexes qui se tissent entre carnet, mobilité et interculturalité. De manière inédite, cet ouvrage croise les regards sur l?objet carnet en proposant des dispositifs institutionnels, des recherches académiques, anthropologiques et didactiques, mais aussi des comptes rendus d?expériences sur le terrain, en classe comme en formation. 606 $aEducation 606 $arécit de voyage 606 $acommunication écrite 606 $amatériel didactique 606 $acarnet de croquis 606 $acahier 610 $arécit de voyage 610 $acommunication écrite 610 $amatériel didactique 610 $acarnet de croquis 610 $acahier 615 4$aEducation 615 4$arécit de voyage 615 4$acommunication écrite 615 4$amatériel didactique 615 4$acarnet de croquis 615 4$acahier 700 $aBriand$b Dominique$01321010 701 $aGuégan$b Marie-Laure$01321011 701 $aHébert-Loizelet$b Sophie$01321012 701 $aJeannin$b Magali$01321013 701 $aLemarchand$b Stéphanie$01321014 701 $aLe Bars$b Corinne$01321015 701 $aLe Bourgeois-Viron$b Roselyne$01321016 701 $aOuvrard$b Élise$01296216 701 $aRebiffé$b Catherine$01321017 701 $aRenaud$b Yves$01321018 701 $aSchneider$b Anne$01076318 701 $aSchneider$b Élisabeth$0394181 701 $aHébert-Loizelet$b Sophie$01321012 701 $aOuvrard$b Élise$01296216 801 0$bFR-FrMaCLE 906 $aBOOK 912 $a9910495907903321 996 $aLes carnets aujourd?hui$93034495 997 $aUNINA LEADER 04206nam 2200673 450 001 9910136793403321 005 20230621140122.0 035 $a(CKB)3710000000631052 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40269 035 $a(EXLCZ)993710000000631052 100 $a20160411d2016 fy| 0 101 0 $aeng 135 $aurmu#---uuuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 182 $ccr$2rdacarrier. 183 $acr$2rdacarrier 200 00$aAdvances in epithelial ovarian cancer$b[electronic resource] $emodel systems, microenvironmental influences, therapy, and origins /$fedited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata 210 $cFrontiers Media SA$d2016 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2016. 210 4$d©2016 215 $a1 online resource (176 pages) $cillustrations; digital, PDF file(s) 225 1 $aFrontiers Research Topics 225 1 $aFrontiers in oncology 311 $a2-88919-769-7 320 $aa Includes bibliographical references. 330 3 $aThis eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a major dilemma as models with the oncogenic aberrations common in the human malignancy do not accurately recapitulate HG-SOC. Conversely, commonly used HG-SOC cell lines have been found to not harbor the expected genetic changes. These issues as well as the rapid acceptance of patient derived xenograft models are reviewed. Five articles discuss different aspects of the tumor microenvironment including its role in therapy resistance, disease progression and metastasis. Mutation of BRCA1/2 continues to be the best defined risk factor for HG-SOC. Three articles discuss BRCA-loss in the context of disease development, targeted therapies and changes in preventative measures proposed for mutation carriers in light of the recent advances in knowledge regarding the origins of this malignancy. An image of HG-SOC with reduced BRCA1 expression is featured on the cover (image by VM Howell). A major clinical issue for patients with HG-SOC is the development of therapy resistance. Five articles focus on therapy resistance and different ways to overcome resistance. Overall, this eBook is an outstanding resource to aid researchers design their programs of research and determine the most appropriate and up-to-date EOC model systems to address their research questions. 410 0$aFrontiers in oncology. 410 0$aFrontiers research topics. 606 $aOvaries$xCancer$xResearch 606 $aNeoplasms 606 $aOncology 610 $a3D-cell culture 610 $aOvarian cancer stem cells 610 $aovarian cancer 610 $atumor-associated macrophage 610 $aBRCA 610 $achemoresistance 610 $afallopian tube 610 $atumour microenvironment 610 $amouse models of ovarian cancer 610 $apatient derived xenografts 610 $aprimary ovarian tumour cells 610 $aAscites 615 0$aOvaries$xCancer$xResearch. 615 0$aNeoplasms. 615 0$aOncology. 676 $a616.99465 700 $aBen Davidson$4auth$01366916 702 $aHowell$b Viive Maarike 702 $aDavidson$b Ben$cM.D., 702 $aWang$b Tian-Li 702 $aAnnunziata$b C$g(Christina) 712 02$aFrontiers Research Foundation, 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136793403321 996 $aAdvances in epithelial ovarian cancer$93389440 997 $aUNINA