LEADER 04188nam 2200577 450 001 9910495234303321 005 20230425143348.0 010 $a3-319-89497-8 024 7 $a10.1007/978-3-319-89497-3 035 $a(CKB)4100000011996290 035 $a(DE-He213)978-3-319-89497-3 035 $a(MiAaPQ)EBC6696320 035 $a(Au-PeEL)EBL6696320 035 $a(OCoLC)1263872356 035 $a(PPN)257353607 035 $a(EXLCZ)994100000011996290 100 $a20220425d2021 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPolyendocrine disorders and endocrine neoplastic syndromes /$fAnnamaria Colao, Marie-Lise Jaffrain-Rea, Albert Beckers, editors 205 $a1st ed. 2021. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (44 illus., 28 illus. in color. eReference.) 225 1 $aEndocrinology (Series : 2018- ) 311 $a3-319-89496-X 320 $aIncludes bibliographical references and index. 327 $aIntroduction.-Auto-immune polyglandular syndromes (APS): an overview -- The natural history of APS1: pathogenesis and long term follow-up -- The genetics of AIRE: an update -- Auto-antibodies in polyendocrine auto-immune disorders: an update -- Rare forms of endocrine and systemic auto-immune disorders: IPEX and ?other POEMS? -- Auto-immune endocrine diseases and cancer immunotherapy -- Part 2: MEN1: an update on molecular diagnosis and clinical implications -- MEN2: an update on molecular diagnosis and clinical implications -- MEN4 and other MEN1-like syndrome -- Genetic alterations in the cAMP pathway: MAS, Carney complex (and AIP?) -- Endocrine tumours associated with SDHx mutations: pheochromocytomas, paragangliomas and pituitary adenomas -- Endocrine tumours in complex genetic disorders: lessons from pheochromocytomas and hyperparathyroidism. 330 $aThis comprehensive reference book is meant to support clinicians in the diagnosis and treatment of polyendocrine diseases and endocrine neoplastic syndromes. Although a large majority of endocrine diseases present as sporadic cases, an increasing proportion can be identified as part of a polyendocrine or systemic syndrome. These include autoimmune endocrine diseases, which may be part of autoimmune polyendocrine disorders (APS) or rare complex disorders such as POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) or IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndromes. On the other hand, endocrine tumors may develop in a variety of clinical conditions, including multiple endocrine neoplasia (MEN) syndromes, syndromic diseases such as McCune Albright or Carney?s complex, or peculiar familial associations such as pheochromocytoma/paraganglioma syndromes. The book discusses the significant advances that have been made in the clinical and genetic characterization of such entities, with major implications in terms of diagnosis and clinical management - with special attention to emerging syndromes, familial screening , multidisciplinarity and multimodal treatment. This volume is intended for clinicians, residents, specialists and physicians involved in the diagnosis and treatment of affected patients, including specialists in endocrinology, internal medicine, oncology , genetics and imaging. . 410 0$aEndocrinology (Series : 2018- ) 606 $aEndocrine glands$xDiseases$xDiagnosis 606 $aMalalties de les glàndules endocrines$2thub 606 $aDiagnòstic$2thub 608 $aLlibres electrònics$2thub 615 0$aEndocrine glands$xDiseases$xDiagnosis. 615 7$aMalalties de les glàndules endocrines 615 7$aDiagnòstic 676 $a616.4075 702 $aColao$b Annamaria 702 $aJaffrain-Rea$b Marie-Lise 702 $aBeckers$b Albert 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910495234303321 996 $aPolyendocrine Disorders and Endocrine Neoplastic Syndromes$91742350 997 $aUNINA LEADER 01473nam a2200265 a 4500 001 991002241239707536 008 070315s20062006it aa 001 0 eng d 020 $a8890266607 035 $ab13497212-39ule_inst 040 $aDip.to Beni Culturali$bita 245 10$aDa Interpromium a Tocco da Casauria :$btremila anni di storia :$bguida del Centro di Documentazione Storico-Archeologica di Tocco da Casauria (Finanziamento Regione Abruzzo - Servizio Promozione Culturale Docup 2000-2006, misura 3.4, azione 3.4.1) /$ca cura di Andrea R. Staffa ; testi di Andrea R. Staffa, Vincenzo d'Ercole 260 $a[Mosciano S. Angelo (TE)] :$bMedia ed.,$cc2006 300 $a96 p. :$bill. ;$c23 cm. 440 0$aGuide d'archeologia pescarese ;$v1 500 $aIn testa al front.: Ministero per i Beni e le Attività Culturali. Direzione Regionale per i Beni Culturali e Paesaggistici per l'Abruzzo. Soprintendenza per i Beni Archeologici per l'Abruzzo - Chieti. Comune di Tocco da Casauria 504 $aContiene bibliografia: pp. 95-96 651 4$aAbruzzo (Italia)$xStoria 700 1 $aStaffa, Andrea R. 700 1 $aD'Ercole, Vincenzo 907 $a.b13497212$b02-04-14$c15-03-07 912 $a991002241239707536 945 $aLE001 AR V 322 8°$g1$i2001000159871$lle001$nDono$og$pE10.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i14396579$z15-03-07 996 $aDa Interpromium a Tocco da Casauria$91096756 997 $aUNISALENTO 998 $ale001$b15-03-07$cm$da $e-$fita$git $h0$i0