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100   $a20220322d2021      uy             0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aCancer biology $ehow science works /$fCarsten Carlberg and Eunike Velleuer
210  1$aCham, Switzerland :$cSpringer,$d[2021]
210  4$d©2021
215   $a1 online resource (179 pages)
311   $a3-030-75698-X 
327   $aIntro -- Preface -- Acknowledgements -- Contents -- Abbreviations -- 1 Introduction to Cancer -- 1.1 The Global Burden of Cancer -- 1.2 Categorization and Diagnosis of Tumors -- 1.3 Crucial Transitions in Cancer -- 1.4 Causes of Cancer -- 1.5 Cancer Prevention -- Further Reading -- 2 Oncogenes and Signal Transduction -- 2.1 Cellular Transformation -- 2.2 Activating Oncogenes in Signal Transduction Pathways -- 2.3 Oncogenic Translocations and Amplifications -- 2.4 The Hallmarks of Cancer Concept -- Further Reading -- 3 Tumor Suppressor Genes and Cell Fate Control -- 3.1 p53 - A Master Example -- 3.2 Tumor Suppressors and Oncogenes in Cell Cycle Control -- 3.3 Tumor Suppressor Inhibition and Cancer Onset -- Further Reading -- 4 Multi-step Tumorigenesis and Genome Instability -- 4.1 Characteristics of Tumor Growth -- 4.2 Multi-step Tumorigenesis -- 4.3 Genome Instability -- 4.4 Cancer Driver Mutations and Genes -- Further Reading -- 5 Cancer Genomics -- 5.1 Human Genetic Variation and Cancer Susceptibility -- 5.2 The Cancer Genome -- 5.3 Cancer Genome Projects -- Further Reading -- 6 Cancer Epigenomics -- 6.1 Epigenetic Mechanisms of Cancer -- 6.2 DNA Methylation and Cancer -- 6.3 Chromatin Changes and Cancer -- 6.4 Epigenetic Reprogramming in Cancer -- Further Reading -- 7 Aging and Cancer -- 7.1 Central Role of Aging During Chronic Diseases -- 7.2 The Hallmarks of Aging -- 7.3 Epigenetics of Aging -- 7.4 Telomeres and Replicative Immortality -- Further Reading -- 8 Tumor Microenvironment -- 8.1 The Impact of the Wound Healing Program for Cancer -- 8.2 Cell Types of the Tumor Microenvironment -- 8.3 Inducing Angiogenesis -- 8.4 Tumor-Promoting Inflammation -- 8.5 Deregulating Cellular Energetics -- Further Reading -- 9 Metastasis and Cachexia -- 9.1 The Metastatic Cascade -- 9.2 Epithelial-Mesenchymal Transition -- 9.3 Metastatic Colonization.
327   $a9.4 Cachexia -- Further Reading -- 10 Cancer Immunity -- 10.1 Outline of Cancer Immunity -- 10.2 Recognition of Tumor Antigens -- 10.3 Monoclonal Antibodies in Cancer Immunotherapy -- 10.4 Immune Cell Therapies -- Further Reading -- 11 Architecture of Cancer Therapies -- 11.1 Classical Cancer Treatments -- 11.2 Targeted Therapies -- 11.3 Precision Oncology -- Further Reading -- Glossary.
606   $aCarcinogenesis
606   $aCancer$xEtiology
606   $aCàncer$2thub
606   $aEtiologia$2thub
608   $aLlibres electrònics$2thub
615  0$aCarcinogenesis.
615  0$aCancer$xEtiology.
615  7$aCàncer
615  7$aEtiologia
676   $a616.994071
700   $aCarlberg$b Carsten$0849346
702   $aVelleuer$b Eunike
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910490024603321
996   $aCancer Biology$92046005
997   $aUNINA