LEADER 04833nam 22006975 450 001 9910485010903321 005 20240208145724.0 010 $a3-030-69852-1 024 7 $a10.1007/978-3-030-69852-2 035 $a(CKB)4100000011918758 035 $a(DE-He213)978-3-030-69852-2 035 $a(MiAaPQ)EBC6607513 035 $a(Au-PeEL)EBL6607513 035 $a(OCoLC)1250347523 035 $a(BIP)078904613 035 $a(PPN)255887426 035 $a(EXLCZ)994100000011918758 100 $a20210507d2021 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEarly Detection and Treatment of Head & Neck Cancers $eTheoretical Background and Newly Emerging Research /$fedited by Rami El Assal, Dyani Gaudilliere, Stephen Thaddeus Connelly 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (XVI, 224 p. 61 illus., 57 illus. in color.) 311 $a3-030-69851-3 327 $aEpidemiology of Head and Neck Cancers -- Epidemiology of Head and Neck Premalignant Lesions -- Mutational Landscape of Head and Neck Cancers -- Genomic and Proteomic Factors of Head and Neck Cancer Progression -- Understanding the Role of Exosomes in Molecular Pathogenesis of Cancers including Head and Neck Cancers -- Risk of Head and Neck Cancers in Systemic Inflammatory Disorders and after Immunosuppressive Treatment -- Metastasis of Brain Tumors (including Glioblastoma) to Head and Neck Region -- Virus-associated Head and Neck Cancers in Immunocompromised and Healthy Patients -- Orofacial Pain-/Oral Adverse Event-associated with Head and Neck Cancers -- EGFR Activation Signature and Modulation in Head and Neck Cancers -- Identification of Genetic Differences between Normal and Tumor Tissues in Head and Neck Cancers -- Cellular Immune Mechanisms of Natural Killer (NK) Cell, Dendritic Cells (DC) and T Lymphocyte Activation Against Head and Neck Cancers -- Statistical Power Analysis in Head and Neck Cancer Studies -- Bioethics in Head and Neck Cancer Research -- Future Perspective of Head and Neck Cancer Research. 330 $aHead and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. This second volume provides an up-to-date overview of the theoretical background in the field of head and neck cancer (HNC) as well as of the emerging research that is impacting our understanding of this disease. The book begins with a comprehensive review of the epidemiology, etiology, symptoms, diagnosis, and staging of HNC. Next, it covers the essentials of potentially malignant disorders of the oral cavity, an important variety of HNC. Subsequently, it covers the newly emerging research in the field of HNC. The overall goal is to shift towards precision medicine (discussed in detail in Volume I), which will bring individualized clinical benefit to patients with HNC. This second volume of Early Detection and Treatment of Head & Neck Cancers concludes with the topic of chronic pain associated with HNC, including both the mechanisms of pain and the management strategies, and the emerging oral mucoadhesive drug delivery approach for HNC. All HNC surgeons, scientists, residents, and individuals whose lives have been touched by this disease, will recognize the impact pain has upon a patient?s health and his or her recovery trajectory. 606 $aOncology 606 $aOtorhinolaryngology 606 $aMouth$xSurgery 606 $aOncology 606 $aOtorhinolaryngology 606 $aOral and Maxillofacial Surgery 606 $aCāncer de cap$2thub 606 $aCāncer de coll$2thub 608 $aLlibres electrōnics$2thub 610 $aInternal Medicine 610 $aMedical 615 0$aOncology. 615 0$aOtorhinolaryngology. 615 0$aMouth$xSurgery. 615 14$aOncology. 615 24$aOtorhinolaryngology. 615 24$aOral and Maxillofacial Surgery. 615 7$aCāncer de cap 615 7$aCāncer de coll 676 $a616.99491 676 $a616.99491 702 $aEl Assal$b Rami$4edt 702 $aGaudilliere$b Dyani$4edt 702 $aConnelly$b Stephen Thaddeus$4edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910485010903321 996 $aEarly Detection and Treatment of Head & Neck Cancers$92239808 997 $aUNINA