LEADER 04090nam 22006495 450 001 9910484833403321 005 20251113204043.0 010 $a3-030-43059-6 024 7 $a10.1007/978-3-030-43059-7 035 $a(CKB)4100000011273154 035 $a(MiAaPQ)EBC6212472 035 $a(DE-He213)978-3-030-43059-7 035 $a(PPN)248397613 035 $a(MiAaPQ)EBC6212343 035 $a(MiAaPQ)EBC29228827 035 $a(EXLCZ)994100000011273154 100 $a20200527d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStiff-Person Syndrome and Related Disorders $eA Comprehensive, Practical Guide /$fby Pichet Termsarasab, Thananan Thammongkolchai, Bashar Katirji 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (xv, 183 pages) $cillustrations 311 08$a3-030-43058-8 320 $aIncludes bibliographical references and index. 327 $aHistorical background of stiff-person syndromes -- Clinical phenomenology and diagnostic criteria of stiff-person syndrome and stiff-person syndrome variants -- Differential diagnosis of stiff-person syndromes -- Electrophysiology of stiff-person syndromes -- Neurochemistry of inhibitory synapses and clinical applications in stiff-person syndromes -- Immunopathogenesis of stiff-person syndromes -- Antibodies in stiff-person syndrome and their correlations with clinical phenotypes -- Anti-glutamic acid decarboxylase 65 (GAD65)-associated syndromes -- Progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome -- Emergencies in stiff-person syndrome -- Diagnostic approach in stiff-person syndrome and its variants -- Treatment of stiff-person syndromes -- Pediatric stiff-person syndromes -- Peripheral hyperexcitability syndromes -- Hyperekplexia. 330 $aThis comprehensive title covers all of the broad aspects of stiff-person spectrum disorders (SPSD), ranging from clinical features and laboratory investigations to the basic scientific roles of neuroimmunology and genetics that aid clinicians in understanding the pathogenesis of this disorder. Organized across 15 chapters, this highly practical book begins with a thorough account of the history and clinical phenomenology of SPSD. Subsequent chapters then delve into the differential diagnoses of the disorder, as well as its electrophysiology, immunopathogenesis, and neurochemistry. Following this is an analysis of each subtype of SPSD including classic stiff-person syndrome and its variants, correlations between clinical phenotypes and antibodies, as well as SPSD in the pediatric population. Finally, the book concludes with an examination of the various SPSD diagnostic approaches, treatments, and potential emergencies seen in clinical practice. Developed by a renowned multidisciplinary authorship, Stiff-Person Syndrome and Related Disorders is an indispensable contribution to the clinical literature and will be of great interest to both clinicians and basic science researchers. 606 $aNeurology 606 $aPsychiatry 606 $aRheumatology 606 $aImmunology 606 $aNeurology 606 $aPsychiatry 606 $aRheumatology 606 $aImmunology 615 0$aNeurology. 615 0$aPsychiatry. 615 0$aRheumatology. 615 0$aImmunology. 615 14$aNeurology. 615 24$aPsychiatry. 615 24$aRheumatology. 615 24$aImmunology. 676 $a616.744 700 $aTermsarasab$b Pichet$4aut$4http://id.loc.gov/vocabulary/relators/aut$0947739 702 $aThammongkolchai$b Thananan$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aKatirji$b Bashar$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484833403321 996 $aStiff-Person Syndrome and Related Disorders$92141769 997 $aUNINA